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Airborne observations conducted during the Northeast Monsoon onset as part of the Cloud Aerosol Interaction and Precipitation Enhancement Experiment (CAIPEEX 2011) are used to link the activation properties of aerosols with the observed cloud microphysics. This study illustrates the significant spatial variability in the aerosol spectrum, cloud condensation nuclei (CCN) activation characteristics,
The manufacturing of miniaturized components is indispensable in modern industries, where the uncut chip thickness (UCT) inevitably falls into a comparable magnitude with the tool edge radius. Under such circumstances, the ploughing phenomenon between workpiece and tool becomes predominant, followed by the notable formation of dead metal zone (DMZ) and piled-up chip. Although extensive models have
The Notch and transforming growth factor-beta (TGF-beta) signaling pathways play critical roles in the control of cell fate during metazoan development. However, mechanisms of cross-talk and signal integration between the two systems are unknown. Here, we demonstrate a functional synergism between Notch and TGF-beta signaling in the regulation of Hes-1, a direct target of the Notch pathway. Activa
Purpose: Patient-specific dosimetry is required to ensure the safety of molecular radiotherapy and to predict response. Dosimetry involves several steps, the first of which is the determination of the activity of the radiopharmaceutical taken up by an organ/lesion over time. As uncertainties propagate along each of the subsequent steps (integration of the time–activity curve, absorbed dose calcula
The Scanian Economic-Demographic Database (SEDD) at the Centre for Economic Demography (CED), Lund University was built to answer questions derived from previous research using macro data from 1749 onwards. It includes longitudinal micro data for a regional sample of rural, semi-urban, and urban parishes in southern Sweden from 1646 to 1968 for approximately 175,000 individuals. In addition to the
In the Gram-positive Firmicute bacterium Bacillus subtilis, amino acid starvation induces synthesis of the alarmone (p)ppGpp by the RelA/SpoT Homolog factor Rel. This bifunctional enzyme is capable of both synthesizing and hydrolysing (p)ppGpp. To detect amino acid deficiency, Rel monitors the aminoacylation status of the ribosomal A-site tRNA by directly inspecting the tRNA's CCA end. Here we dis
The transition of Escherichia coli from the exponential into the stationary phase of growth induces the stringent response, which is mediated by the rapid accumulation of the alarmone nucleotide (p)ppGpp produced by the enzyme RelA. The significance of RelA's functionality during the transition in the opposite direction, i.e. from the stationary phase into new exponential growth, is less well unde
Background and aim: Whether long-term oxygen therapy (LTOT) improves survival in interstitial lung disease (ILD) is unclear. A recent study reported similar survival in ILD patients with severe hypoxemia on LTOT vs. moderate hypoxemia without LTOT, and proposed that LTOT could be indicated in ILD already at moderate hypoxemia. The aim of this study was to compare survival by severity of hypoxemia
BACKGROUND: Loss of heterozygosity (LOH) at chromosome 1p is a common abnormality in both parathyroid tumors and pheochromocytomas. The recently characterized tumor suppressor gene RIZ1, located at 1p36, has emerged as a putative candidate to be involved in endocrine tumorigenesis.MATERIAL: Presence of allelic loss, promoter hypermethylation, and mutational aberrations of the RIZ1 gene were invest
Although co-infections and interactions of parasites are a very common phenomenon in the wild, information received from studies on avian Plasmodium spp. is scarce and fragmented due to its complex nature. Different interactions of parasites and domination of one parasite may have a detrimental effect on transmission success of another pathogen. Untangling these interactions and competitive behavi
Att planera lokal och regional kollektivtrafik i så kallade ’starka stråk’ – det vill säga att koncentrera infrastruktur och resurser till ett antal färre, men attraktivare stråk i en stad eller en region – är ett standardförfarande i samtida kollektivtrafikplanering. Så har inte alltid varit fallet dock. Denna avhandling visar hur organiseringen av beslutsfattande, planeringspraktiker och den rumPlanning local and regional public transport in so-called ’transit corridors’ – i.e., to concentrate infrastructure and resources to few, but more attractive corridors in a city or a region – is commonplace in contemporary public transport planning. This has not always been the case, however. In this thesis I analyze how transit corridors have come to dominate the policies and planning practices o
Objective: To study occupational groups and occupational exposure in association with chronic obstructive respiratory diseases. Methods: In early 2000s, structured interviews on chronic respiratory diseases and measurements of lung function as well as fractional expiratory nitric oxide (FENO) were performed in adult random population samples of Finland, Sweden and Estonia. Occupations were categor
Different methods can be used to define healthy vascular ageing (HVA). In this prospective cohort study, we explored three different definitions in order to provide guidance for which to use. 2718 subjects were included from the Cardiovascular (CV) arm of the Malmö Diet Cancer Study (MDCS; median age 71.9 years, 62.2% females). Three different definitions of HVA were used: HVA-1 (<15th percentile
Industrial energy efficiency is important for reducing CO2 emissions and could be a competitive advantage for companies because it can reduce costs. However, cost-effective energy efficiency measures are not always implemented because there are barriers inhibiting their implementation. Drivers for energy efficiency could provide means for overcoming these barriers. The aim of this article was to s
Precarious employment (PE) is a well-known social determinant of health and health inequalities. However, as most previous studies have focused on physical and mental well-being, less is known about the social-related outcomes (ie, social precarity) associated with precarious arrangements. This cross-sectional study aims to investigate whether PE is associated with social precarity in a working po
Both disturbed sleep and lack of exercise can disrupt metabolism in pregnancy. Accelerometery was used to objectively assess movement during waking (physical activity) and movement during sleeping (sleep disturbance) periods and evaluated relationships with continuous blood glucose variation during pregnancy. Data was analysed prospectively. 15-women without pre-existing diabetes mellitus wore con
There are several well-known risk factors for work-related musculoskeletal disorders (MSDs). Despite this knowledge, too many people still work in harmful conditions. The absence of occupational exposure limits (OELs) for physical workload impedes both supervision and preventive work. To prevent myalgia, tendon disorders, and nerve entrapments in the upper musculoskeletal system, we propose action
The United Nations is the arena for a renewed push to regulate transnational corporations (TNCs) and their supply chains. This article analyses the ongoing efforts of a multilateral organization to strengthen the human rights legal framework, especially the design choices posed by the treaty negotiations as well as the role of the UN Human Rights Council in the broader regulatory ecosystem around
