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The accumulation of tau abnormality in sporadic Alzheimer’s disease is believed typically to follow neuropathologically defined Braak staging. Recent in-vivo PET evidence challenges this belief, however, as accumulation patterns for tau appear heterogeneous among individuals with varying clinical expressions of Alzheimer’s disease. We, therefore, sought a better understanding of the spatial distri
Novel immunotherapies for cancer and other diseases aim to trigger the immune system to produce durable responses, while overcoming the immunosuppression that may contribute to disease severity, and in parallel considering immunosafety aspects. Interleukin-2 (IL-2) was one of the first cytokines that the FDA approved as a cancer-targeting immunotherapy. However, in the past years, IL-2 immunothera
This extended abstract compiles statistics and information regarding the process of gathering water damage statistics. A questionnaire wasused to determine similarities, differences, and tendencies in the water damage statistics, in the Nordic countries Sweden, Norway, Denmark,Finland and Iceland. The study aimed to answer what lessons were learned and what knowledge could be shared between the No
Europe has experienced severe drought events in recent decades, posing challenges to understand vegetation responses due to diverse vegetation distribution, varying growth stages, different drought characteristics, and concurrent hydroclimatic factors. To analyze vegetation response to meteorological drought, we employed multiple vegetation indicators across European biomes. Our findings reveal th
In recent years, shared micro-mobility services (e.g., bikes, e-bikes, and e-scooters) have been popularized at a rapid pace worldwide, which provide more choices for people’s short and medium-distance travel. Accurately modeling the choice of these shared micro-mobility services is important for their regulation and management. However, little attention has been paid to modeling their choice, esp
Shared electric scooters (e-scooters) have been rapidly growing in popularity across Europe over the past three years, which can bring various environmental and socioeconomic benefits. However, how to further improve the usage efficiency of shared e-scooters is still a major concern for micro-mobility operators and city planners. This paper proposes a machine learning based approach to predict the
Red blood cell (RBC) and iron status biomarkers are commonly used in clinical diagnostics. However, interpretations of infant test results are inherently challenging. Modern well-defined comparative data based on presumably healthy term-born infants have mainly been lacking and interpretations could be further complicated by interference from frequent infections. Moreover, the trends that follow w
Encapsulation in self-assembled lipid structures has been shown to increase the stability of large biomolecules, including proteins and nucleic acids (NAs), which has many potential applications in the food and pharmaceutical industries. In order to fully optimise the encapsulation system for a certain application, however, it is important to understand the effect of the encapsulated biomolecule o
We characterize the model spaces K in which functions with smooth boundary extensions are dense. It is shown that such approximations are possible if and only if the singular measure associated to the singular inner factor of is concentrated on a countable union of Beurling Carleson sets. In fact, we use a duality argument to show that if there exists a restriction of the associated singular measu
Despite the importance of SMEs for innovation activity, questions remain concerning the determinants of their innovative performance and the role of different types of collaboration and partners. The present paper empirically analyzes the role played by different types of R&D collaborations in the persistence of SME innovative performance. We used a longitudinal database to identify all the Sw
Kan en silkeshandske vara en symbol för makt? I denna tänkvärda volym samlas en grupp namnkunniga historiker för att ge perspektiv på överlappande frågor kring genus, materialitet och politik. Genom historiska fallstudier som sträcker sig från 1500-talet och fram i modern tid utforskar författarna brännpunkter i företeelser som diplomati, kvinnors inflytande och tillskrivandet av betydelse hos förCan a silk glove be an expression of power? In this carefully curated volume, internationally renowned historians have come together to explore the interconnected perspectives of gender, materiality, and politics. As the authors elaborate on these topics, the volume offers contributions covering a period from the sixteenth century to the present day, investigating political culture and diplomacy,
The focus of much sensory language research has been on vocabulary and codability, not how language is used in communication of sensory perceptions. We make a case for discourse-oriented research about sensory language as an alternative to the prevailing vocabulary orientation. To consider the language of sound in authentic textual data, we presented participants with 20 everyday sounds of unknown
Business angels are a vital source of capital for innovative start-up firms. However, many potentially attractive investment opportunities are rejected during the angel's decision-making process. Information asymmetry, risk and distrust in the relationship between the investor and the entrepreneur result in investment barriers. The concept of proximity has been proposed as a conceptual foundation
With the two nations taking steps towards a more harmonized agenda on climate change mitigation, we would expect these leading plastic producer countries to also show leadership in relation to plastics.
