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Effect modification of ambient particle mortality by radon: A time series analysis in 108 U.S. cities

Numerous studies have reported a positive association between ambient fine particles and daily mortality, but little is known about the particle properties or environmental factors that may contribute to these effects. This study assessed potential modification of radon on PM2.5 (particulate matter with an aerodynamic diameter <2.5 ?m)-associated daily mortality in 108 U.S. cities using a two-stag

Transcription factor AP-4 is a ligand for immunoglobulin-κ promoter E-box elements

Immunoglobulin (Ig)-κ promoters from humans and mice share conserved sequences. The octamer element is common to all Ig promoters and pivotal for their function. However, other conserved sequence motifs, that differ between lg variable gene families, are required for normal promoter function. These conserved motifs do not stimulate transcription in the absence of an octamer. One example is an E-bo

Observation of the solvent shell reorganization around photoexcited atomic solutes by picosecond X-ray absorption spectroscopy

We report on the observation of the solvation shell rearrangement after abstraction of the electron from aqueous I - in a laser pump/X-ray probe experiment by recording the X-ray absorption L 1 - and L 3 -edge spectra, 50 ps after laser excitation. The L 1 -edge spectra clearly identify the I 0 neutral species after excitation and suggest a substantial amount of back-transfer of charge from the s

The Role of Image Quality in Telehealth: Adoption Challenges in the Subcontinent

Background: The purpose of this paper is to explore the underlying challenges in the telehealth environment in India and Pakistan that impede the delivery of high-quality images between a patient and health care professional.Method: An exploratory study was conducted among healthcare professionals in India and Pakistan to assess their perceptions regarding image quality, which is used for the diag

Plasma Alkylresorcinols is an objective biomarker for gluten intake in young children

BackgroundAlkylresorcinols are a well-established biomarker for whole grain intake. There is evidence suggesting that total plasma alkylresorcinol concentration may also be used as a biomarker for gluten intake in adults.ObjectiveThe aim of the study was to evaluate if total alkylresorcinol concentration is a valid biomarker for gluten intake in young children.MethodsNon-fasting plasma alkylresorc

Human IgE against the major allergen Bet v 1 - defining an epitope with limited cross-reactivity between different PR-10 family proteins.

The interaction between IgE and allergen is a key event at the initiation of an allergic response, and its characteristics have substantial effects on the clinical manifestation. Despite this, the molecular details of the interaction between human IgE and the major birch allergen Bet v 1, one of the most potent tree allergens, still remain poorly investigated.

Axon morphology is modulated by the local environment and impacts the noninvasive investigation of its structure-function relationship

Axonal conduction velocity, which ensures efficient function of the brain network, is related to axon diameter. Noninvasive, in vivo axon diameter estimates can be made with diffusion magnetic resonance imaging, but the technique requires three-dimensional (3D) validation. Here, high-resolution, 3D synchrotron X-ray nano-holotomography images of white matter samples from the corpus callosum of a m

A sustainable working life for all ages – The swAge-model

The demographic shift is fast becoming a global challenge and an important public health concern. The proportion of people over 65 years is currently 10% around the world, but it is expected to rise to 22% by the year 2050 [1]. Populations ageing rapidly is widely seen as one of the most powerful transformative forces affecting society over the next four decades [1–4]. The ageing population is pro

Stellar abundance of binary stars : Their role in determining the formation location of super-earths and ice giants

Binary stars form from the same parent molecular cloud and thus have the same chemical composition. Forming planets take building material (solids) away from the surrounding protoplanetary disc. Assuming that the disc's accretion on to the star is the main process that clears the disc, the atmosphere of the star will show abundance reductions caused by the material accreted by the forming planet(s

Automating MALDI Sample Plate Loading

We describe the design and implementation of a generic robotic solution to automate the loading of MALDI sample plates into a mass spectrometer. The soft- and hardware aspects are described together with the various safety issues that need to be addressed. The automation increases thoughput by a factor of between 5- and 80-fold.

Disability, Justice and Freedom as Non-Domination

Disability scholars have recently proposed that republican theory is relevant to think about justice in relation to disability. Following in their footsteps, this article submits that the republican conception of freedom as non-domination provides a fresh angle to legitimise disability rights in terms of justice and prevent their interpretation as charity or privileges. This proposition takes its

Prognostic implications of structural heart disease and premature ventricular contractions in recovery of exercise

Premature ventricular contractions (PVCs) during recovery of exercise stress testing are associated with increased cardiovascular mortality, but the cause remains unknown. We aimed to evaluate the association of PVCs during recovery with echocardiographic abnormalities, and their combined prognostic performance. Echocardiographic abnormalities [reduced left ventricular (LV) ejection fraction, valv

Multilevel Climate Governance in Brazil and Indonesia : Domestic Pioneership and Leadership in the Global South

Focusing on forest policy and urban climate politics in Brazil and Indonesia, the primary objective of this chapter is to identify domestic pioneers and leaders who, compared to other sectors, governmental levels or jurisdictions within the same nation-state, move ‘ahead of the troops’ (Liefferink and Wurzel, 2017: 2-3). The chapter focuses especially on the role of multilevel governance in bringi

Degrowth

This chapter is devoted to introducing degrowth to anyone interested in environmental politics and making connections between the two areas. It articulates critiques of growth, alternatives associated with degrowth and the politics of pursuing them. It is argued that economic growth, with GDP being its key indicator, comes with environmental degradation and is rooted in injustices. Degrowth schola