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Chromosome abnormalities, in particular translocations, and gene fusions are hallmarks of neoplasia. Although both have been recognized as important drivers of cancer for decades, our knowledge of the characterizing features of the cytobands involved in recombinations is poorly understood. The present study, based on a comparative analysis of 10 442 translocation breakpoints and 30 762 gene fusion

Primary retinal cell cultures and immunocytochemistry are important experimental platforms in ophthalmic research. Translation of retinal cells from their native environment to the in vitro milieu leads to cellular stress, jeopardizing their in vivo phenotype features. Moreover, the specificity and stability of many retinal immunochemical markers are poorly evaluated in retinal cell cultures. Henc

We have recently considered the problem of tuning a static plant described by a differentiable input-output function, which is completely unknown, but whose Jacobian takes values in a known polytope of matrices: to drive the output to a given desired value, we have suggested an integral feedback scheme, whose convergence is ensured if the polytope of matrices is robustly full row rank. The suggest

To simplify the analysis of complex dynamical networks, we have recently proposed an approach that decomposes the overall system into the sign-definite interconnection of subsystems with a Positive Impulse Response (PIR). PIR systems include and significantly generalise input-output monotone systems, and the PIR property (or equivalently, for linear systems, the Monotonic Step Response property) c

INTRODUCTION: : The aldosterone/renin ratio (ARR) is the first line screening test for primary aldosteronism (PA). However, in hypertensive patients with an increased ARR, PA needs to be confirmed by other means. METHODS: : A 25 mg oral captopril test was performed in 16 healthy subjects to obtain reference values for aldosterone and ARR at 120 minutes after the test. Subsequently these data were

An introduction to the anthology Perspectives on the Entangled History of Communism and Nazism. A Comnaz Analysis.

Large-scale science research facilities, such as those for investigation into the smallest components of physical matter, often consist of buildings with quite extraordinary features as regards shape and scale. These architectures are semiotically interesting in several ways: they have extraordinary outer forms that reflect the their inner activities; they require forms of mediation and planning t

International Journal of Molecular Medicine ISSN 1107-3756

This paper focuses on a reliability analysis of an offshore wind turbine support structure which is part of an assessment and monitoring framework for wind turbines in operation. The reliability analysis builds upon structural, loading, limit state and uncertainty models comprising design, production and erection data. This model basis facilitates the reliability analysis of the ultimate, the fati

This study aims to: (1) identify some of the active and latent conditions that allow maritime security incidents to occur, and (2) explore the feasibility of adapting the Rasmussen-Svedung AcciMap as a tool for maritime security management. These twin objectives are pursued by applying concepts and principles, propounded by Rasmussen and Svedung, to a case study of the 1999 hijacking of the Alondr

We describe the implementation of a FrameNet-based semantic role labeling system for Swedish text. To train the system, we used a semantically annotated corpus that was produced by projection across parallel corpora. As part of the system, we developed two frame element bracketing algorithms that are suitable when no robust constituent parsers are available. Apart from being the first such system

In this paper we present a novel concept and methodology for generating tailored communication protocols specific to an application¿s requirements and the operating environment for a mobile node roaming among different access networks within the global Internet. Since the scheme that we present employs a universal technique, it can be also deployed in smallscale independent networks such as sensor

This essay discusses the dissemination of atrocity images in contemporary mass media, from the photographs of mass-graves in the Nazi concentration camps to the pictures of torture of Iraqi prisoners in Abu Ghraib. The central question is one of distances: the distance between the image and the event, between the picture and the beholder, and between the destroyed human body and the cultural forms

The base of the world economic pyramid, generally called the base of the pyramid (BoP), consists of four billion people with average daily income of four dollars. Over the past several years, the design and development of products and services for BoP markets has been investigated by several authors from different disciplines. While some authors suggest a systems approach to design and develop pro

The study of psychosocial is highly relevant for project-based sector like construction owing to the following justifications: mobility of workers, constant change of workplace, diversity of work performed, physically demanding, high health and safety risk, meeting deadlines, monetary constraints and male-dominated industry. All these factors contribute to the industry having unique and different

In recent years, systems for resource allocation in academic research based on performance indicators have been introduced in many European countries (Hicks, 2012). Today, we are at a point where the use of bibliometrics based indicators for research evaluation and resource allocation more or less permeates academic systems on all levels and across the world. The implementation—and the effects of