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Cancer can be regarded as an invasive organ that exhibits unique plasticity provided by coordinated, cancer cell-stromal cell communication in the tumour microenvironment. Typical stress factors in the tumour niche, such as hypoxia and acidosis, are major drivers and modulators of these events. Recent findings reveal an important role of extracellular vesicles and lipoproteins in cancer cell adapt
Civil society is often understood as a normative vehicle for the promotion of human rights and democracy, as it plays a central role in ensuring gender equality and advocating for local ownership in the decision-making processes of states. Civil society agents and organizations have been instrumental in promoting and advancing the Women, Peace, and Security (WPS) agenda. In this chapter, we examin
Breathlessness that persists despite treatment for the underlying conditions is debilitating. Identifying this discrete entity as a clinical syndrome should raise awareness amongst patients, clinicians, service providers, researchers and research funders.Using the Delphi method, questions and statements were generated via expert group consultations and one-to-one interviews (n=17). These were subs
Motivated by experimental findings on one-dimensional nano-materials, this contribution focusses on the elaboration of a fibre curvature based higher-order gradient contribution to the stored energy function in a finite deformation setting. The presented approach is based on the fundamental theoretical developments for fibre-reinforced composites presented by Spencer and Soldatos (2007), which tak
Purpose -The purpose of this paper is to investigate the added value of using temperature-dependent electric and magnetic properties in high-Temperature electromagnetic simulations. Design/methodology/approach - In this work, the electromagnetic properties of Domex 420, SSAB, have been characterized as a function of the temperature, from room temperature to 900°C. The measurement of the electric a
This chapter considers the phenomenon of mixed hoards, containing both minted and non-minted silver, from the Baltic island of Bornholm. Rather than following a general Scandinavian trend towards coin-only hoards, on Bornholm mixed hoards dominated until the twelfth century. They are often interpreted as signifying a somewhat primitive bullion economy, within which coins, ingots, jewellery, and sc
Autoimmune hepatitis (AH) and primary biliary cirrhosis (PBC) are autoimmune diseases (AIDs) targeting cellular components of the liver. Being rare diseases, limited data are available about familial risks among these AIDs (concordant) or between them and other AIDs (discordant). We aimed to carry out an unbiased study on these AIDs based on medically diagnosed patients. We collected data on patie
Three-dimensional (3D) imaging of dynamic objects that rapidly undergoes structural changes, such as turbulent combusting flows, has been a long-standing challenge, mainly due to the common need for sequential image acquisitions. To accurately sense the 3D shape of the sample, all acquisitions need to be recorded within a sufficiently short time-scale during which the sample appears stationary. He
Many observed giant planets lie on eccentric orbits. Such orbits could be the result of strong scatterings with other giant planets. The same dynamical instability that produces giant planet scatterings can also alter the orbits of terrestrial planets. For example, a habitable rocky planet in the system can be ejected or transported to an orbit outside the habitable zone. Therefore, there is a lin
Introduction. We present qualitative questionnaires, originally an ethnological method for documenting and collecting material about everyday life, as a fruitful method for information studies. Method. Since the early 20th century qualitative questionnaires, on various themes, have been sent out to informants. The answers to qualitative questionnaires consist of memories, opinions and experiences.
