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Functional analysis of the alpha10beta1 integrin

Popular Abstract in Swedish Brosk är en speciell typ av vävnad, som bl.a. finns på våra ledytor, där det fungerar som ett stötdämpande och skyddande lager för benet. Broskets viktiga egenskaper framstår klart vid sjukdomar, som artros, där brosket på ledytor har förstörts och benet blottläggs, vilket resulterar i en permanent smärta. Brosk produceras av den enda celltyp som finns i broskvävnaden; The aim of this thesis was to study the function of the integrin a10b1. Integrins mediate signals between cells and their environment and regulate several cellular processes such as cell migration, proliferation and differentiation. The a10b1 integrin is expressed mainly by chondrocytes, the only cell type present in cartilage, and facilitates binding of the chondrocytes to the extracellular matri

Effect of maternal betamethasone on fetal and uteroplacental blood flow velocity waveforms.

Abstract OBJECTIVES: To investigate the effects of antenatal betamethasone on fetal and uteroplacental hemodynamics. METHODS: The study comprised 33 women with singleton high-risk pregnancies (23-33 weeks; 27 pregnancies < 30 weeks) not in labor, but at risk for preterm delivery based on fetal or maternal indications. They were treated with two doses of 12 mg betamethasone intramuscularly 24 h ap

Cytokine responses during mucosal infections: role in disease pathogenesis and host defence

Mucosal pathogens use diverse and highly specific molecular mechanisms to activate mucosal inflammation. It may even be argued that their virulence depends on the inflammatory response that they induce. Some bacteria target epithelial cells and trigger them to produce inflammatory mediators but others cross the mucosa and activate macrophages or dendritic cells. Although systemic release of inflam

Is Competitive Elite Sport Really Morally Corrupt?

It has been argued that competitive elite sport both a) reduces the humanity of athletes by turning them into beings whose sole value is determined in relation to others, and b) is motivated by a celebration of the genetically superior and humiliation of the weak. This paper argues that while a) is a morally reproachable attitude to competition, it is not what competitive elite sport revolves arou