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Objectives: The aim of this study was to estimate the cost-effectiveness of rituximab in patients not responding adequately to the first tumor necrosis factor (TNF) inhibitor using a model constructed to predict resource consumption and health outcomes in a population-based registry of biological treatments in Southern Sweden (SSATG). Methods: The model was developed as a discrete event simulation
To evaluate the cost-effectiveness of an additional 12-week treatment with varenicline for abstainers who had successfully completed an initial 12-week treatment. The Benefits of Smoking Cessation on Outcomes simulation model was used to simulate both direct and indirect effects of smoking cessation. All calculations were performed in 2003 Swedish prices. Sweden in 2003. The modelled cohort consis
The composition of the microbial community in the rhizosphere was investigated using three different techniques: direct soil-phospholipid fatty acid (PLFA), cfu-PLFA (using culturable, bacteria only) and community-level physiological profiles (CLPP) using Biolog GN microtitre plates. All three techniques showed that the rhizosphere bacterial community differed from the bulk soil community, when pe
In this paper we study the distribution of the product of an inverse Wishart random matrix and a Gaussian random vector. We derive its asymptotic distribution as well as its approximate density function formula which is based on the Gaussian integral and the third order Taylor expansion. Furthermore, we compare obtained asymptotic and approximate density functions with the exact density which is o
OBJECTIVES: To estimate the total direct medical costs to society for patients with type 2 diabetes in Sweden and to investigate how different factors, for example diabetic late complications, affect costs. DESIGN: Cross-sectional data regarding health care utilization, clinical characteristics and quality of life, were collected at a single time-point. Data on resource use cover the 6-month perio
Aim: To estimate, on a national basis in Sweden, the costs versus consequences of combined maternity ward and well-baby clinic eye screening compared to well-baby clinic screening alone. Methods: Two scenarios were created and compared regarding healthcare costs: visual acuity development and quality-adjusted life-years (QALYs). One scenario represented early management ( combined maternity ward a
The influence of external precipitating factors and the presence of peripheral neuropathy on the development and outcome of foot ulcers were evaluated in 314 consecutive diabetic patients. All patients were treated by the same foot care team. Each patient was represented by one ulcer, and primary healing was defined as intact skin for at least six months. External precipitating factors were identi
Results from a Monte Carlo investigation are presented for the application of the dual photopeak window (DPW) scatter correction method to phantom geometries of varying shapes, sizes, and densities as well as to several collimators. A Monte Carlo program was used to simulate a Tc-99m point source at locations of 0.5 cm from the phantom surface, at the center, 0.5 cm from the bottom, and 4/5 the di
The aim of this work was to evaluate the measurement properties and hierarchical item structure of the Epworth Sleepiness Scale (ESS) in patients with Parkinson's disease (PD). Data were taken from a cross-sectional study regarding fatigue and sleep-related aspects of PD. One hundred and eighteen consecutive patients with neurologist-diagnosed PD without significant co-morbidities (54% men; mean a
Popular Abstract in Swedish Proteiner är helt nödvändiga för alla former av liv på jorden. En typisk cell består till 50-60 % av proteiner, om man bortser från vatten. Det är ett protein, hemoglobin, som transporterar syre från lungorna till kroppens celler och ger blodet dess röda färg. Det är ett protein, alfa- keratin, som bygger upp vårt hår och våra naglar. Det är två proteiner, aktin och myoProtein S is a modular protein and a cofactor in the protein C anticoagulant system. It consists of a Gla-module, a thrombin-sensitive loop, four EGF-modules and a SHBG-like module. Protein S has previously been shown to contain four binding sites with high affinities for Ca2+ (Ka>9x105 M-1 at physiological ionic strength) and at least one of the sites h
The flagellate Euglena gracilis shows rhythms in phototaxis and cell shape changes between oblong and round. Artificial UV-B radiation of 0.5 W m-2 caused a loss in phototaxis, but the peak of activity occurred at the same time as for control cells. The transition from round to oblong cell shape was slower after UV-B radiation, but the amplitude between the roundest and the most oblong cell shape
Om Raoul Wallenberg och Oskar Schindler som hjältar i svensk, tysk, europeisk och amerikansk efterkrigstida bearbetning av andra världskriget och förintelsen.
In Rabinowicz (2008), I considered how value relations can best be analysed in terms of fitting pro-attitudes. In the formal model of that paper, fitting pro-attitudes are represented by the class of permissible preference orderings on a domain of items that are being compared. As it turns out, this approach opens up for a multiplicity of different types of value relationships, along with the stan
The literature on universities' contributions to regional development is broad and diverse. A precise understanding of how regions may draw advantages from various university activities and the role of public policy institutions in promoting such activities is still missing. The aim of this paper is to provide a framework for analysing universities' contributions to regional economic and societal
This study examines the expected retirement replacement rates (RRs) of several cohorts of Dutch employees at the time of their planned retirements. It also computes RRs based on the available pension records. We find that the expected replacement rate (E(RR)) is, in general, higher than the ones we compute. Larger discrepancies are found for younger cohorts and for individuals with less education
Background: Alcohol use disorders (AUD) involving hazardous, harmful, and addictive misuse of alcohol are widespread in most parts of the world. The aim of this study was to review the effect of disulfiram in the treatment of patients with AUD. The effect of disulfiram was evaluated according to the primary outcome of an intake of alcohol below 30 and 20 g/d for men and women, respectively, as we
Recombinant activated factor VII (rFVIIa) was initially developed to treat bleeding episodes in patients with congenital haemophilia and inhibitors. The story of its development began in the 1970s, when FVIIa was identified as one of the activated coagulation factors that has minimal potential for inducing thromboembolic side-effects. Extensive research over the last 30 years has greatly increased
Objective. We sought to measure the bone mineral density (BMD) of various regions in the maxilla before implant treatment and to investigate correlations between these values and the BMDs of the spine and hip. Study design. Eighteen patients were examined by means of quantitative computed tomography, and the BMD of the maxillary alveolar ridge was calculated. The same patients also underwent dual-
