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Defects in the mitochondrial protein frataxin are responsible for Friedreich ataxia, a neurodegenerative and cardiac disease that affects 1:40,000 children. Here, we present the crystal structures of the iron-free and iron-loaded frataxin trimers, and a single-particle electron microscopy reconstruction of a 24 subunit oligomer. The structures reveal fundamental aspects of the frataxin mechanism.
When reading this book you are embarking on an ethnographic journey, granting you access into the field of ethnography, its methods, knowledge claims and aims. The journey takes you to the indigenous people of Japan, a warrior Nation in Canada and Wall Street financial actors. The book reaches beyond fragmentary knowledge of the studied people and opens up for illustrating not only ethnography in
The Holocaust takes on different significance whether is it perceived as belonging to Jewish historical culture, to Hungarian historical culture or to Romanian historical culture – or whether these historical cultures are thought of, in ethnic terms, as bivalent. Thus, using the same concepts as the ones concerning certain individuals’ orientation in a bicultural environment, one can argue that th
This article offers narratives of individual journeys through the scholarship of leading in three different contexts—Asia, Europe, and Africa. Together, these narratives argue for the need to make explicit the diversity of practices of the scholarship of teaching and learning (SoTL), with each practice inextricably tied to specific geographical, sociocultural, and political contexts. In offering t
This article examines the changing role of the Swedish state in employmentand welfare regulation in an environment that has become more market driven,commodified, and Europeanized. It begins with a theoretical reflection on the role of the state in capitalist development and a review of the recent debate on the spatiality of state regulation: the state as employer, redistributor, and arbiter, and
This chapter examines how prenatal diagnosis was discussed and interpreted when translated from laboratories and clinics into the public arena. It focusses on debates about policy and regulation in the early 1980s. Drawing on the concept of co-production the chapter argues that when groups outside the medical context discussed prenatal diagnosis, other values and norms were mobilized. Thus, in ord
Interdisciplinary research in the fields of forestry and sustainability studies often encounters seemingly incompatible ontological assumptions deriving from natural and social sciences. The perceived incompatibilities might emerge from the epistemological and ontological claims of the theories or models directly employed in the interdisciplinary collaboration, or they might be created by other ep
[3H]Arachidonic (20:4) and [14C]linoleic acid (18:2) were fed to thoracic duct-cannulated rats in test meals of either tracers alone, cream, Intralipid, pure arachidonic acid, or pure linoleic acid. Less [3H]20:4 than [14C]18:2 was recovered in chyle during the first 5 h. After cream feeding, the proportion of radioactivity found in phospholipids was high and increased during the first 3 h. After
A high-resolution study of the (e,e'p) reaction on Helium-4 was carried out at the Institut fuer Kernphysik in Mainz, Germany. The measurements were done in parallel kinematics (momentum transfer q=685 MeV/c, energy transfer omega=334 MeV) at different incident beam energies in order to enable the Rosenbluth separation of the longitudinal and transverse response functions.
The aim of the paper was to investigate EFL (English as a foreign language) primary school teachers’ beliefs regarding their teaching methods used in English at grade 5 in the classroom, which was a part of my PhD research (Son, 2018). Interviews (teachers at Grade 5 observed classes; Responses N=2, Sweden and N=3, Vietnam) and questionnaires to English teachers at grade 5 in Swedish and Vietnames
The arctic tern Sterna paradisaea completes the longest known annual return migration on Earth, traveling between breeding sites in the northern arctic and temperate regions and survival/molt areas in the Antarctic pack-ice zone. Salomonsen (1967, Biologiske Meddelelser, Copenhagen Danske Videnskabernes Selskab, 24, 1) put forward a hypothetical comprehensive interpretation of this global migratio
A description of the cultural landscape in the Romele area, southern Sweden, during the Bronze Age and Early Iron Age.
