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The MLL gene in chromosome band 11q23 is frequently rearranged in acute lymphoblastic and acute myeloid leukemias. To date, more than 50 different chromosomal regions are known to participate in translocations involving 11q23, many of which affect MLL. The pathogenetically important outcome of these rearrangements is most likely the creation of a fusion gene consisting of the 5' part of the MLL ge

AIM: The aim of this paper is to investigate structure, content and effects of systematic clinical supervision (SCS). BACKGROUND: Home care staff caring for people with dementia were offered SCS because the increasing number of elderly people with dementia increases the demands made on nurses. METHOD: Supervisors (n = 5) and SCS participants (n = 6) were interviewed and an additional 52 SCS partic

This article presents two formerly unedited travelaccounts, transcribed from the Swedish manuscripts and translated into English, narrating visits to Herculaneum, the Herculanense Museum and Pompeii, by Georg Fröman, Royal maçon, and Johan Tobias Sergel, sculptor, respectively. The texts are commented and put in historical context. Sergel's thorough accout of the Museum is read in parallel with th

A selective and sensitive reversed-phase high-performance liquid chromatographic method for simultaneous analysis of diltiazem and its five metabolites known to occur in man is presented. Different C18 columns are compared. The influences of organic co-solvent, pH, ionic strength and the addition of various amines are studied. The use of trans-diltiazem as internal standard is advocated. UV detect

This article chronicles the most recent history of the Deutsches Elektronen-Synchrotron (DESY) located in Hamburg, Germany, with particular emphasis on how this national laboratory founded for accelerator-based particle physics shifted its research program toward multi-disciplinary photon science. Synchrotron radiation became DESY’s central experimental research program through a series of changesThis article chronicles the most recent history of the Deutsches Elektronen-Synchrotron (DESY) located in Hamburg, Germany, with particular emphasis on how this national laboratory founded for accelerator-based particle physics shifted its research program toward multi-disciplinary photon science. Synchrotron radiation became DESY’s central experimental research program through a series of changes

This article explores the advocacy activities of the Church of Sweden. The historical co-optation of the Church by the state, a Lutheran theological heritage, and a trend from “voice to service” within Swedish civil society might discourage stronger political activism by the Church. The following research questions are answered: How does the extent of the advocacy activities of the Church of Swede

This article looks at chronic crisis on an empirical example of radiation embodiment by survivors of a nuclear disaster. Developing further the work of Henrik Vigh, this article argues that chronic crisis is conflictual in nature, where some individuals fully embrace it, while others reject it. A total of 16 in-depth interviews were conducted with survivors of the Chernobyl nuclear disaster from B

Under 2013 utgjorde värdet av medlemsstaternas offentliga upphandling ungefär 18 procent av deras BNP, vilket gör det till ett kraftfullt verktyg att använda för att främja vissa samhällsmål. Traditionellt sett så har offentlig upphandling använts i ett protektionistiskt syfte för att skydda nationell industri från utländsk konkurrens, vilket är en bidragande faktor till att EU har valt att lagstIn 2013, approximately 18 % of member states GDP was spent on public procurement, making it a powerful tool for governments to use to further certain objectives. Traditionally, public procurement has been used for protectionist purposes to safeguard national industry from foreign competition, which is why the EU has chosen to regulate this area of law to ensure the proper functioning of the inter

Bakgrund. Industrierna utsätts för allt större press att anpassa sig till de håll- barhetsregler som införs. Detta tvingar industrierna att utmana de traditionella tillverkningsprocesser och hitta sätt att göra dem mer hållbara. I de traditionella industrierna används mycket kylvätska, som har stor inverkan på både den miljön och den sociala hållbarheten. Två produktionsmetoder uppvisar betydande Background. Industries are facing increasing pressure to adapt to sustainability regulations being put in place. This forces industries to rethink traditional manufac- turing operations and find ways to make them more sustainable. In the traditional industries there are a lot of coolants being used, these have a big impact on both the environment sustainability as well as social sustainability. Tw

This thesis examines how small-scale farmers and food artisans in Germany are impacted by and respond to the pressures of the global food system. It is based on the in-depth analysis of a case study of a recultivation effort of the traditional rye variety ‘Mecklenburger Marienroggen’ in Mecklenburg Vorpommern, Northeast Germany. I employ a thematic analysis of semi- structured interview data and s

This thesis critically explores gender equality in international development, focusing on Guatemala amidst resurgent right-wing politics, volatile commitment, and gender backlash. It investigates how institutions like the Food and Agriculture Organization (FAO) navigate gender mainstreaming in a country with fluctuating dedication to gender equality. Through mixed methods, including thematic analy

With two centuries of forestry, natural forests in boreal Sweden are rare and strongly fragmented. Hence, restoration aiming to improve conditions for forest biodiversity is needed. However, to ensure landscape connectivity – where to restore is a critical concern.Our study objective was to identify connectivity forest that through restoration support connectivity and biodiversity. The study area

Abstract: The FIFA World Cup, together with the Summer Olympic Games, are the two events classified as sports mega-events (SMEs), characterized by their global outreach and different types of costs. Within the SME realm, a paradoxical trend can be seen; they show stronger sustainability agendas, yet generate higher social, economic, and environmental costs. The overarching question is their legaci

As one of the primary countries of destination for migrant domestic workers in Asia, Singapore is a developed country with one of the highest standards of living in the region. Yet, the city-state has been on the receiving end of extensive criticism concerning the rights and protections of migrant domestic workers. Civil society organizations have been one of the loudest critics, and in recent pub

Young adult novels about suicide are questioned pieces of literature. Fears of suicide contagion and the perceived unsuitability of such narratives for adolescents lie at the centre of this conflict, which has resulted in the banning of books and other censorship moves. Suicide in literature has been the focus of relatively scarce previous research, and there is a need for further literary critici