Search results

The insulin receptor substrate (IRS)-1 is an important component of the insulin signal transduction cascade. Several reports suggest that a Gly-->Arg change in codon 972 is associated with type 2 diabetes and related traits, and a recent meta-analysis reported a modest but nominally significant association with type 2 diabetes (odds ratio [OR] 1.25 in favor of carriers of the Arg allele [95% CI 1.

This statement provides a concise list of diagnostic terms for ECG interpretation that can be shared by students, teachers, and readers of electrocardiography. This effort was motivated by the existence of multiple automated diagnostic code sets containing imprecise and overlapping terms. An intended outcome of this statement list is greater uniformity of ECG diagnosis and a resultant improvement

The adsorption of N2O on Ir(110) was investigated with high-resolution resonant photoemission at 135 K. The results obtained show evidence of molecular adsorption of N2O, along with some dissociation. It is found that the nitrogen photoemission spectra measured at the terminal and central nitrogen energy positions of the N2O/Ir(110) system are equivalent to those of N2O in the gas phase. In contra

Climate change is expected to have profound ecological effects, yet shifts in competitive abilities among species are rarely studied in this context. Blue tits (Cyanistes caeruleus) and great tits (Parus major) compete for food and roosting sites, yet coexist across much of their range. Climate change might thus change the competitive relationships and coexistence between these two species. Analys

The identification of intestinal macrophages (mφs) and dendritic cells (DCs) is a matter of intense debate. Although CD103(+) mononuclear phagocytes (MPs) appear to be genuine DCs, the nature and origins of CD103(-) MPs remain controversial. We show here that intestinal CD103(-)CD11b(+) MPs can be separated clearly into DCs and mφs based on phenotype, gene profile, and kinetics. CD64(-)CD103(-)CD1

Regulating the choice between neural stem cell maintenance versus differentiation determines growth and size of the developing brain. Here we identify TGF-beta signaling as a crucial factor controlling these processes. At early developmental stages, TGF-beta signal activity is localized close to the ventricular surface of the neuroepithelium. In the midbrain, but not in the forebrain, Tgfbr2 ablat

Endotoxin exposure is associated with wheeze and asthma morbidity, while early life exposure may reduce risk of allergy and asthma. Unfortunately, it is difficult to compare endotoxin results from different laboratories and environments. We undertook this study to determine if lipopolysaccharide ( LPS) extraction efficiency could account for differences among laboratories. We generated and collect

A method for evaluating a band offset of a heterojunction is proposed by measuring temperature dependence of current-voltage (I-V) characteristics in triple-barrier resonant tunneling diodes (TBRTDs). The method was applied for investigating a conduction band offset by using GaAs0.25P0.75/GaAs TBRTDs with thin strain heterobarriers grown by MOCVD and DeltaE(c) was estimated as 200-240 meV. In the

The ability to predict clinical image quality from physical measures is useful for optimization in diagnostic radiology. In this work, clinical and physical assessments of image quality are compared and correlations between the two are derived. Clinical assessment has been made by a group of expert radiologists who evaluated fulfillment of the European image criteria for chest and lumbar spine rad

Specific nutrients or foods have been inconsistently associated with ulcerative colitis (UC) or Crohn's disease (CD) risks. Thus, we investigated associations between diet as a whole, as dietary patterns, and UC and CD risks.

Idiopathic Scoliosis is a spinal deformity affecting approximately 3% of otherwise healthy children or adolescents. The etiology is still largely unknown but has an important genetic component. Genome-wide association studies (GWAS) have identified a number of common genetic variants that are significantly associated with idiopathic scoliosis in Asian and Caucasian populations, rs11190870 close to

Case volume per 100 000 population and perioperative mortality rate (POMR) are key indicators to monitor and strengthen surgical services. However, comparisons of POMR have been restricted by absence of standardised approaches to when it is measured, the ideal denominator, need for risk adjustment, and whether data are available. We aimed to address these issues and recommend a minimum dataset by

Popular Abstract in Swedish Kroppens rörelser åstadkommes genom sammandragning av muskelvävnad som kan vara av två slag, glatt eller tvärstrimmig. Den senare sorten kan indelas i skelett och hjärtmuskulatur, vilka har mycket olika egenskaper trots den gemensamma benämningen. Muskelvävnaden är uppbyggd av långsträckta, spolformade celler som innehåller tunna och tjocka kontraktila filament, beståenThe initial signal for contraction in smooth muscle is an increase in [Ca2+]i. Ca2+ ions can either enter the cytosol from the extracellular medium or be released from intracellular stores. Voltage-operated Ca2+ channels (VOC) play a dominant role in the activation of smooth muscle contraction. This thesis describes two novel regulatory mechanisms of the dihydropyridine (DHP)-sensitive VOC in smoo

Mot bakgrund av de globala klimatambitionerna har den folkrättsliga traktaten Energistadgefördraget (ECT) kommit att ifrågasättas med ökande intensitet. I synnerhet anses Investor-State Dispute Settlement (ISDS) mekanismen i artikel 26 ECT inskränka staters rätt att lagstifta och därigenom bromsa utfasningen av fossila energislag (regulatory chill). En ISDS-mekanism är vanligt förekommande i gränAgainst the backdrop of global climate ambitions, the international treaty known as the Energy Charter Treaty (ECT) has come under increasing scrutiny. In particular, the Investor-State Dispute Settlement (ISDS) mechanism in Article 26 ECT is seen as restricting states' right to legislate and thereby slow-ing down the phasing out of fossil fuels (regulatory chill). ISDS is a common mechanism

Summary This paper deals with the form requirement from the perspective of Swedish law, especially the form requirement, contractual rights and obligations in the situation when immovable property has been transferred and the parties have not concurrently signed the purchase documents. Transfer of immovable property is an exception from AVTL's rules because it is a special contract managed b

Var och en som har blivit anklagad för ett brott åtnjuter en rätt till tystnad och att betraktas som oskyldig genom det straffprocessuella förfarandet fram till en eventuellt fällande dom. Dessa grundläggande rättigheter tillförsäkras den tilltalade genom artikel 6.1 och 6.2 EKMR. Som en följd av dessa rättigheter ligger bevisbördan i brottmål uteslutande på åklagaren, vilket medför en rätt för deEveryone charged with criminal offense has the right to remain silent and to be presumed innocent until proven guilty in criminal proceedings. The accused is assured these fundamental rights according to article 6.1 and 6.2 ECHR. Due to these rights, the burden of proof must lie on the prosecutor, which means that the accused has the right to remain completely passive during criminal proceedings.

Denna rapport ska undersöka vilka moment på en svensk byggarbetsplats som bidrar med den största mängden slöseri och hur företag med hjälp av två olika Lean-metoder kan minska på dessa. Denna rapport ska undersöka vilka moment på en svensk byggarbetsplats som bidrar med den största mängden slöseri och hur företag med hjälp av två olika Lean-metoder kan minska på dessa.Utifrån de 27 svar som inkomm

Frågan om hur uppsåtsbedömningen ska göras på självförvållat berusade personer är erkänt problematisk, och de olika lösningar som finns tycks aldrig bereda en fullständig tillfredställelse. Just balansgången mellan å ena sidan effektivitetsskälen och å andra sidan rättsäkerheten har visat sig svår att gå, då de är två motstående intressen som båda behöver tillgodoses för att uppnå en fullgod lösniThe question about how the subjective test of intention shall be done on self-induced intoxicated persons has been recognized as problematic, and the various solutions available never seem to give sufficient satisfaction. Especially the balancing act between so called efficiency reasons and on the other hand the rule of law has been proved difficult, as they are conflicting interests that both mus

Global urbanization creates opportunities and challenges for humanwell-being and transition towards sustainability. Urban areas are human-environment systems that depend fundamentally on ecosystems, and thus require an understanding of the management of urban ecosystem services to ensure sustainable urban planning. The purpose of this study is to provid easy stematic review of urban ecosystem sser