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T2 cytokine-driven alarmin and antiviral responses in asthma: insights into immune modulation and the role of IL-4Ra targeting

Introduction: Severe asthma is a heterogeneous condition characterized bydistinct phenotypes and endotypes based on clinical or biologicalcharacteristics. Interleukin (IL) 4 and IL-13 are central cytokines in the type 2(T2) immune response, crucial for T2 inflammation. Biologic therapiestargeting the IL-4/IL-13 pathway, such as anti-IL-4Rα monoclonal antibodies(mAbs), have shown improvements in luIntroduction: Severe asthma is a heterogeneous condition characterized by distinct phenotypes and endotypes based on clinical or biological characteristics. Interleukin (IL) 4 and IL-13 are central cytokines in the type 2 (T2) immune response, crucial for T2 inflammation. Biologic therapies targeting the IL-4/IL-13 pathway, such as anti-IL-4Rα monoclonal antibodies (mAbs), have shown improvements

Recommendations for the standardization and interpretation of the electrocardiogram. Part I: The electrocardiogram and its technology. A scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society

This statement examines the relation of the resting ECG to its technology. Its purpose is to foster understanding of how the modern ECG is derived and displayed and to establish standards that will improve the accuracy and usefulness of the ECG in practice. Derivation of representative waveforms and measurements based on global intervals are described. Special emphasis is placed on digital signal

Integritetsfrågor i arbetslivet

Popular Abstract in Swedish Denna avhandling behandlar ämnesområdet integritet i arbetslivet. Individer i ett modernt samhälle har anspråk på respekt eller icke angrepp inom sitt intresseområde. Arbetslivet utgör ett exempel på ett sådant område. Min utgångspunkt då jag behandlar ämnet är främst individens (arbetstagarens) prima-facie anspråk på respekt, icke angrepp inom sitt intresseområde. IntThis dissertation deals with personal privacy in working life. Humans have legitimate expectations and claims to respect for and non-interference with personal privacy in many areas and stages of life. The work place is just one of them. The point departure when dealing with privacy matters at the workplace is primarily the claim by individual employees to respect for and non-interference with the

Review of particle physics

This biennial Review summarizes much of Particle Physics Using data from previous editions, plus 2205 new measurements from 667 papers, we list, evaluate, and average measured properties of gauge bosons, leptons, quarks, mesons, and baryons We also summarize searches for hypothetical particles such as Higgs bosons, heavy neutrinos, and supersymmetric particles All the particle properties and searc

A new rectal model for dosimetry applications

A revised geometric representative model of the lower part of the colon, including the rectum, the urinary bladder and prostate, is proposed for use in the calculation of absorbed dose from injected radiopharmaceuticals. The lower segment of the sigmoid colon as described in the 1987 Oak Ridge National Laboratory mathematical phantoms does not accurately represent the combined urinary bladder/rect

Recommendations for the standardization and interpretation of the electrocardiogram: part I: The electrocardiogram and its technology: a scientific statement from the American Heart Association Electrocardiography and Arrhythmias Committee, Council on Clinical Cardiology; the American College of Cardiology Foundation; and the Heart Rhythm Society: endorsed by the International Society for Computerized Electrocardiology

This statement examines the relation of the resting ECG to its technology. Its purpose is to foster understanding of how the modern ECG is derived and displayed and to establish standards that will improve the accuracy and usefulness of the ECG in practice. Derivation of representative waveforms and measurements based on global intervals are described. Special emphasis is placed on digital signal

Fruits and vegetables and renal cell carcinoma: Findings from the European Prospective Investigation into Cancer and Nutrition (EPIC)

We examined the association between fruits and vegetables and risk of renal cell carcinoma (RCC) in the European Prospective Investigation into Cancer and Nutrition (EPIC). Dietary intake data and complete follow-up information on cancer incidence were available for 375,851 participants recruited in EPIC centers of 8 countries. During an average follow-up of 6.2 years, 306 incident cases of RCC we

Treatment aims and philosophy in the treatment of adolescent anorexia nervosa in Europe

This study describes the range of service provision and explores differences in treatment approaches and therapeutic aims, in the 12 countries participating in the European Union collaborative COST B6 Adolescent Project into the treatment of adolescent anorexia nervosa (AN). Following a number of group meetings, two questionnaires were administered, completed and returned by e-mail. The first ques

Sensitivity of EEHG simulations to dynamic beam parameters

Currently, the Free electron laser user facility FLASH at DESY is undergoing a significant upgrade involving the complete transformation of one of its beamlines to allow external seeding. With the Echo-Enabled Harmonic Generation (EEHG) seeding method, we aim for the generation of fully coherent XUV and soft X-ray pulses at wavelengths down to 4 nm. The generated FEL radiation is sensitive to vari

Studies on the host response to infection in the circulatory system

Popular Abstract in Arabic Vårt immunförsvar är fantastiskt. Dagligen exponeras vi för bakterier, virus och andra sjukdomsalstrande mikroorganismer och i allra flesta fall besegrar vårt immunförsvar detta hot utan problem. I sällsynta fall uppstår det dock en situation då bakterier lyckas undvika vårt initiala immunförsvar, sprids i kroppen och orsakar blodförgiftning (sepsis). Vid detta tillståndSepsis is a heterogeneous, dynamic, and complex syndrome caused by interaction between the host and the invading pathogen. It is associated with an overwhelmingly dysregulated immune response, and also immunosuppression. In spite of our improved understanding of the underlying molecular pathology, sepsis still remains a common cause of morbidity and mortality worldwide. This is reflected in the un

Working papers (äldre)

2016 "Soft Europeanisation of Work-Family Reconciliation Policy-making? - Social, Policy and Political Learning among German MPs". Gühlstorf, Alisa, 2016. Working paper nr. 55 (PDF 563.9 KB, ny flik)   “Knocking on Europe’s door… - Investigating modes of governing and the principle of solidarity as EU member states respond to the asylum pressure on its southern borders”. Nørager, Marie Brink, 2016

https://www.cfe.lu.se/verksamhet/publikationer/working-papers-aldre - 2026-05-27

Synthetic studies towards new substances for treatment of Chaga's disease.

I dagens samhälle präglas vår samtid av nyheter om krigsdrabbade områden och naturkatastrofer, vilket är två orsaker till att migrationen runt om i världen ökar. Människor förlorar sina hem och vissa är på ständig flykt. Detta är ett fruktansvärt öde som också bidrar till spridningen av sjukdomar som tidigare varit begränsade till vissa kontinenter. Chagas sjukdom, även känd som amerikansk trypaChagas disease, also known as American Trypanosomiasis, is a parasitic infection caused by the triatomine bugs, commonly referred to as kissing bugs. It is the deadliest parasitic disease in South America but has spread beyond this region due to migration and climate change. Approximately 70 million people are at risk of infection, and there is no cure for the chronic phase of the disease. In prev

Uppföljning av patienter behandlade för depression inom rehabiliteringsgarantin, Primärvården, Region Skåne, i termer av antalet återfall efter avslutad behandling samt om tidigare depressionsepisoder och socialt stöd kan predicera återfall i depression.

Sammanfattning Syftet med den här studien var att undersöka återfallsfrekvensen i depression under påföljande sex månader efter avslutad behandling, hos personer som nyligen avslutat en depressionsbehandling inom rehabiliteringsgarantin, Primärvården, Region Skåne, samt att undersöka om antalet depressionsepisoder och socialt stöd kan predicera återfall i depression. 50 personer deltog i studien. Abstract The aim of this study was to investigate the frequency of relapse in depression during the following six months after completed treatment, for individuals that recently had finished a treatment for depression in rehabiliteringsgarantin, Primary Care, Region Skåne, and to examine if the number of episodes and social support may predict relapse in depression. 50 individuals participated in

A vegetation map and a digital elevation model over the Kapp Linné area, Svalbard : with analyses of the vertical and horizontal distribution of the vegetation

En vegetationskarta och en digital höjdmodell har gjorts över ett 54 km2 stort område beläget på Svalbards västkust, vid Isfjorden. Vegetationskartan är baserad på flygbilder och en undersökning gjord i fält under juli månad 1994. Systemet som användes vid klassificeringen av de olika vegetationstyperna är utarbetad av Elven et al. (1990) för en liknande studie i Gipsdalen på Svalbard. Vår vegetatA vegetation map and a Digital Elevation Model has been generated over a 54 km2 area situated at the western coast of Svalbard, at the Isfjorden fiord. The map is based on aerial photographs and a field survey made during the summer of 1994. The classification system used is described by Elven et alia (1990), for a similar study in Gipsdalen in the inner part of Isfjorden. The classification of th

The New MAX IV Gun Test Stand

The gun test stand from MAX-Lab has been upgraded and moved to a new facility at the MAX IV Laboratory. The new test stand will reuse parts of the equipment from the old test stand but a number of improvements to the setup are be made. In this paper we report on the design of the new gun test stand, research plans in the near future as well as planned and possible future research topics..

Kinetics and Mechanism for Reduction of Gold(III) Complexes by Dimethylsulfide

The reactions between trans-[Au(CN) 2 X 2 ] - (X = Cl or Br) and Me 2 S have been studied by conventional and high-pressure stopped-flow spectrophotometry in acidic aqueous solution containing 10% (w/w) methanol. The overall stoichiometry Au III ∶Me 2 S is 1∶(1.0 ± 0.1) in agreement with the reaction: trans-[Au(CN) 2 X 2 ] - + Me 2 S + H 2 O → [Au(CN) 2 ] - + Me 2 SO + 2H + + 2X - . Initial rapid

An estrogen receptor mutant with strong hormone-independent activity from a metastatic breast cancer

Thirty tumors from metastatic breast cancer patients were screened for mutations in the estrogen receptor (ER) gene using single-strand conformation polymorphism and sequence analysis. Three missense mutations, Ser47Thr, Lys531Glu, and Tyr537Asn, were identified in these lesions. To investigate these mutated ERs or altered transcriptional activation function, expression vectors containing wild-typ

Kalltrask e 2019 kartlaggning av samverkan och samberoenden for sektorerna elektronisk kommunikation

Rapport från dokumentstudien Evelina Kallträsk Avdelningen för Riskhantering och Samhällssäkerhet LTH, Lunds universitet 29 november 2019 Isf-Projektet: Dokumentanalys Kartläggning av samverkan och samberoenden för sektorerna elektronisk kommunikation, energiförsörjning och transporter Sammanfattning Följande rapport består av en studie som genomförts inom ramen för ett ISF-finansierat projekt ko

https://www.cencip.lu.se/sites/cencip.lu.se/files/kalltrask_e_2019_kartlaggning_av_samverkan_och_samberoenden_for_sektorerna_elektronisk_kommunikation_energiforsorjning_och_transporter.pdf - 2026-05-27