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Background: Free and total human kallikrein 2 (hK2) might improve the discrimination between prostate cancer and benign prostatic hyperplasia. Concentrations of hK2 are 100-fold lower than concentrations of prostate-specific antigen (PSA); therefore, an hK2 assay must have a low detection limit and good specificity. Methods: PSA- and hK2-specific monoclonal antibodies were used in solid-phase, two
Ischemia is accompanied by mitochondrial dysfunction, as assessed by measurements of mitochondrial respiratory activities in vitro. Following brief periods of ischemia, mitochondrial function is usually normalized during reperfusion. However, particularly after ischemia of longer duration, reperfusion may be accompanied by secondary mitochondrial failure. After short periods of ischemia this is ob
A diagnosis-antibiotic prescribing study was performed in 5 counties in Sweden during 1week in November in the y 2000 and 2002, respectively. As part of the study, the characteristics and clinical management of patients who received diagnoses of urinary tract infections (UTIs) ( n = 1564) in primary care, were analysed. 85% of the visits were by women, and 74% of all consultations were diagnosed a
The CEDAR collaboration is developing a set of tools for tuning and validating theoretical models by comparing the predictions of event generators with data from particle physics experiments. CEDAR is also constructing resources to provide access to well defined versions of high-energy physics software and support for software developers. Here we give an overview of the CEDAR project and its statu
The quality and quantity of UV measurements have increased greatly in the last few years. Variations among measurements from different instruments are diminishing toward the 5% level. Long-term trend detection is still a problem, with little historical data available for baseline estimations. Enhanced UV levels are clearly associated with the Antarctic springtime ozone reductions. Measurements sho
During an 11-year period 117 extraanatomic reconstructions were made for aorto-iliac arteriosclerosis; 36 axillofemoral and 81 femorofemoral crossover bypasses. The patients were old and had several factors making them poor risks for surgery. Axillofemoral grafts were more often used in patients with malignant disease. Postoperative mortality was 10% without difference between the two types of rec
We studied prospectively the change over ten years in mortality, walking ability and place of residence after a hip fracture in 753 patients in Japan. We compared the deaths observed in these patients with those expected in the general population, matched for age, gender and calender year at the time of fracture. The survival rate decreased dramatically for two years after the event and the mortal
The aim of this study was to investigate the use of single-dose pharmacokinetic data for factor IX (FIX) to predict multidose pharmacokinetics and explore their use for pharmacokinetic dosing in prophylactic treatment of haemophilia B. Eight patients with severe haemophilia B were enrolled. Using single-dose pharmacokinetic data for each patient, plasma factor IX procoagulant activity (FIX:C) curv
Membrane type 1-matrix metalloprotease (MT1-MMP or MMP-14) is a major activator of pro-MMP-2 and is essential for skeletal development. We show here that it is required for branching morphogenesis of the submandibular gland but not the lung. Instead, in the lung, it is essential for postnatal development of alveolar septae. Lung development in Mmp14-/- mice is arrested at the prealveolar stage wit
Brevmall Postadress Lunds universitet, Box 117, 221 00 Lund Besöksadress Scheeletorget 1, Medicon Village E-post johanna.mellgren@fs.lu.se Webbadress www.fs.lu.se Forskningsserv ice Johanna Mel lgren Forskningshandläggare Vetenskapliga projekt av större storlek, arkeologi eller konstvetenskap, Berit Wallenbergs Stiftelse. Sista ansökningsdag 1 juni 2020. Med vetenskapliga projekt av större storlek
En enskild persons eller ett lags prestationer inom idrotten har alltid fascinerat mänskligheten. Det har genom tiderna alltid funnits individer som har urskiljt sig från mängden genom sin personlighet och förmåga att bättre utöva en idrott. Dessa individer blir ofta populära och en förebild för många. Det kommer hela tiden fram nya aktörer som lyfter idrotten till nya nivåer men samtidigt blir ko
BACKGROUND: Adverse drug reactions are a significant reason for therapeutic failure during thiopurine treatment of inflammatory bowel disease. Some smaller series in this patient population have shown that a switch to mercaptopurine may be successful in many cases of azathioprine intolerance. AIM: To assess the long-term outcome of mercaptopurine treatment in a large patient population with azathi
Previous research indicates an uneven uptake of biologics in patients with moderate-to-severe psoriasis in Sweden. Therefore, it is essential to scrutinise variations in treatment patterns.
