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Immunotherapy aims to enhance the immune system’s response to cancer. Different immunotherapies exist, such as cytokine therapies and immune checkpoint inhibitors. The FDA has approved immunomodulatory drugs, such as Proleukin, a recombinant IL-2 cytokine, Nivolumab, and Avelumab, which are immune checkpoint inhibitors. However, these drugs lead to side effects in patients known as immune-related
The ECJ’s judgment of 27 January 2021 in the case C-595/18 P (the ”Goldman Sachs case”) has caused a big buzz in the ever growing Private Equity sector. It confirmed the ruling of the GCEU of July 2018 case T-419/14 which in turn confirmed the Commission’s decision according to which Goldman Sachs has been held liable for an antitrust infringement committed by one of its portfolio companies. In al
Mitigation of greenhouse gas (GHG) emissions is essential for us humans to curb climate change. Around a fifth of the anthropogenic GHG emissions stem from the construction sector. Much come from energy used for space and water heating within buildings, but an increasing proportion comes from the manufacturing of the building materials and is virtually embodied within buildings. This is called Emb
The aim of this thesis was threefold: (i) study the association behaviour of β-casein, (ii) study the electrostatic and conformational properties of β-casein, and (iii) evaluate the possibility of using β-casein as a model protein for the acidic proline rich protein (PRP-1). Dynamic light scattering (DLS) was used to determine the size of β-casein aggregates that were formed in aqueous solutions
Football supporters’ violence in Sweden is a current societal issue, which lacks experimental investigations. The current study aims to address this gap by investigating social and cognitive factors in order to better understand the mechanisms behind legitimation of violence towards supporters of the opposing team (the out-group). A football supporter and a social science student samples answered
Change towards a sustainable company is driven either by media or the company, the argument goes. It is though questionable, if companies as individual actors have an impact on the environment at all, or if they are too small in the global economy. Using the macro- economic gravity model, the size question can be answered positively, the companies do have an impact. Thus reasons why companies chan
This thesis investigates how the experience of founding a youth-led social-innovation project can enhance young people’s agency for sustainable development, through a qualitative single-case study of Ashoka Belgium’s 2023 Youth for Change (Y4C) programme. Grounded in a social-constructivist, abductive logic, the study uses semi-structured interviews and mobilises three strands of scholarship—Socia
Despite its importance, rural groundwater quality in Rwanda remains insufficiently monitored. This study aimed to investigate the groundwater quality, its health implications as well as how management can be improved to reduce the health risks of rural boreholes in the Nyagatare district in Rwanda. In total 61 boreholes were visited and 48 groundwater samples were collected. Analysis was conducted
This thesis examines how outnovation is enacted within design entrepreneurship, with fashion design entrepreneurship as the empirical context. It analyses how value formed through design practice may contribute to sustainable competitive advantage. Understood as an alternative innovation logic centred on authenticity, nostalgia, simplicity, and sustainability, outnovation offers a counterpoint to
A search is performed for dark matter particles produced in association with a resonantly produced pair of (Formula presented)-quarks with (Formula presented) using (Formula presented) of proton-proton collisions at a center-of-mass energy of 13 TeV recorded by the ATLAS detector at the LHC. This signature is expected in extensions of the standard model predicting the production of dark matter par
Micropollutant removal is a key component of the revised Urban Wastewater Treatment Directive (UWWTD) and can be achieved with ozonation. During ozonation, the composition of the wastewater matrix and the targeted treatment level for individual micropollutants or groups of such compounds affect ozone consumption. In this work, it was hypothesized that nitrite scavenging, the point of dosing (befor
A search for T and Y vector-like quarks produced in proton-proton collisions at a centre-of-mass energy of 13 TeV and decaying into Wb in the fully hadronic final state is presented. The search uses 139 fb−1 of data collected by the ATLAS detector at the LHC from 2015 to 2018. The final state is characterised by a hadronically decaying W boson with large Lorentz boost and a b-tagged jet, which are
Hydraulic balancing is key to ensure proper operation of the heating system. When the heating system is not hydraulically balanced, heat is unevenly distributed across dwellings resulting in a wide temperature spread, overheating, and consequently, wastage of energy. In this paper, we study to which extent hydraulic imbalance affects the thermal energy demand of buildings. Furthermore, key variabl
INTRODUCTION: Autoantibodies against insulin (IAA) are early appearing markers of autoimmunity against the pancreatic islet beta cells and predict progression to type 1 diabetes if additional islet autoantibodies also develop. It is still controversial if proinsulin rather than insulin is the primary autoantibody.METHODS: The aim of the present study was to compare the half-maximal concentration (
PurposeCombination treatments—thermal ablation (TA) and transarterial chemoembolisation (TACE) have been suggested for hepatocellular carcinoma (HCC). After TA a transient hyperemic zone appears around the ablated area, a potential target for TACE. The aim was to determine when this peri-ablational hyperemia is at its widest and most intensely perfused.Materials and methodsThis prospective study e
The thesis examines the truth and reconciliation commission in South Africa and its possibilities to act as a vehicle in the process of consolidating democracy. The norms and values that can be found in the principles and practices of the commission are scrutinized, and the means of presenting this norms to the public is also looked into. The issue of how to deal with the human rights violations o
This research approaches public administration reform in China from a domestic perspective. Whereas recognizing that the mechanisms behind the nature differ from the principle of New Public Management (NPM) of Anglo-Saxon tradition, the reform initiatives are similar. Municipal governments were encouraged to carry out NPM Reform towards governance model since 1998 to serve dual-purpose. That is st
