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Background: von Willebrand disease (VWD) type 1 is a congenital bleeding disorder caused by genetic defects in the von Willebrand factor (VWF) gene and characterized by a reduction of structurally normal VWF. The diagnosis of type 1 VWD is difficult because of clinical and laboratory variability. Furthermore, inconsistency of linkage between type 1 VWD and the VWF locus has been reported. Objectiv
Freshwater demand is expected to rise while supplies decline, putting pressure on water systems. Water conservation and determining potential alternative sources is imperative. The thesis aims to determine the effectiveness of greywater recycling as an alternative source in Sweden. Sörsjön was used as a case study and the roles of property owners and water utilities explored. The theory of planned
This thesis explores the effects of institutional arrangements for innovation in clusters. Clusters have become one of the most popular concepts in innovation policy studies in recent years. They have been ascribed as places with structures that reduce transaction costs, and enable innovation processes due to the prevalence of different types of externalities. The focus of this dissertation is on
Popular Abstract in Swedish Streptococcus pyogenes Människan är ständigt koloniserad av en mängd olika mikroorganismer. De flesta bakterier är ofarliga och en del av dem är faktiskt nödvändiga för oss, t.ex. de tarmbakterier som hjälper oss att producera vitaminer. Grupp A streptokocker (GAS) eller Streptococcus pyogenes, är en av de vanligaste sjukdomsframkallande bakterierna hos människan. De kaWe have found that a set of group A streptococcal strains, primarily associated with skin infections, express surface-associated M proteins that bind plasminogen and plasmin with high affinity. The binding is mediated by a common 13 amino acid internal repeated sequence located in the NH2-terminal surface-exposed portion of these M proteins. It could be demonstrated that plasminogen, absorbed by t
[1] The timing of magmatic events forming Jurassic basaltic rocks in Dronning Maud Land (DML), Antarctica, and hydrothermal activity that affected them is addressed with detailed Ar-40/Ar-39 incremental heating dating of feldspars. Plagioclase from an Utpostane gabbro and from a Kirwanveggen dolerite dike yield indistinguishable plateau ages at 177 +/- 1.8 Ma. Because of geologic controls, this es
Background Long-term outcome after hematopoietic stem cell transplantation including late transplant-related events is of increasing interest. The aim of this study was to evaluate the incidence of cardiovascular events after allogeneic HSCT and to search for their risk factors. Design and Methods This is a retrospective mutlicenter European Group of Blood and Marrow Transplantation (EBMT) analysi
A search is presented for production of a heavy up-type quark (t') together with its antiparticle, assuming subsequent decay to a W boson and a b quark, t'(t) over bar' -> W(+)bW(-)(b) over bar. The search is based on 1.04 fb(-1) of proton-proton collisions at root s = 7 TeV collected by the ATLAS detector at the CERN Large Hadron Collider. Data are analyzed in the lepton + jets final state, chara
This research presents the modeling of the anaerobic digestion of cane-molasses vinasse, hereby extending the Anaerobic Digestion Model No. 1 with sulfate reduction for a very high strength and sulfate rich wastewater. Based on a sensitivity analysis, four parameters of the original ADM1 and all sulfate reduction parameters were calibrated. Although some deviations were observed between model pred
BACKGROUND: The role of sleeping problems in the causal pathway between job strain and musculoskeletal pain is not clear. Purpose: To investigate the impact of sleeping problems and job strain on the one-year risk for neck, shoulder, and lumbar pain. METHOD: A prospective study, using self-administered questionnaires, of a healthy cohort of 4,140 vocationally active persons ages 45-64, residing in
This paper presents a search for Higgs bosons decaying to four leptons, either electrons or muons, via one or two light exotic gauge bosons Z(d), H -> ZZ(d) -> 4l or H -> Z(d)Z(d) -> 4l. The search was performed using pp collision data corresponding to an integrated luminosity of about 20 fb(-1) at the center-of-mass energy of root s = 8 TeV recorded with the ATLAS detector at the Large Hadron Col
Background: Accurate measurement of von Willebrand factor (VWF) is a critical requirement for the diagnosis of von Willebrand disease (VWD). Aim of the study: To evaluate the diagnostic efficiency of a rapid quantitative test for the measurement of VWF antigen (VWF:Ag) in type 1 VWD. Patients and methods: VWF: Ag was measured with an ELISA in a robotic instrument, as a reference method, and with a
Background: The slopes of the eastern Andes harbour some of the highest biodiversity on Earth and a high proportion of endemic species. However, there have been only a few and limited descriptions of carbon budgets in tropical montane forest regions. Aims: We present the first comprehensive data on the production, allocation and cycling of carbon for two high elevation (ca. 3000 m) tropical montan
Purpose To explore the effect of high-dose ifosfamide in first-line treatment for patients <= 40 years of age with nonmetastatic osteosarcoma of the extremity. Patients and Methods From March 1997 to September 2000, 182 patients were evaluated. Primary treatment consisted of two blocks of high-dose ifosfamide (15 g/m(2)), methotrexate (12 g/m(2)), cisplatin (120 mg/m(2)), and doxorubicin (75 mg/m(
Objective: Previous research has shown that elderly and disabled travelers using Special Transportation Services (STS) are injured without being involved in a vehicle crash. In order to estimate the true costs for these vehicle-related injuries, the focus needs to be adjusted towards an incident/traveler-oriented perspective. The aim of the project was thus to utilize such a perspective, in order
The citations of highly cited papers in the life sciences published in 1986 and 2000 was examined to determine the extent to which early impact predicts long term impact. Linear correlation between early and post-peak impact was found to be about 0.7
Objective. Previous research has shown that elderly and disabled travelers using Special Transportation Services (STS) are injured without being involved in a vehicle crash. In order to estimate the true costs for these vehicle-related injuries, the focus needs to be adjusted towards an incident/traveler-oriented perspective. The aim of the project was thus to utilize such a perspective, in order
