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INTRODUCTION: Autoantibodies against insulin (IAA) are early appearing markers of autoimmunity against the pancreatic islet beta cells and predict progression to type 1 diabetes if additional islet autoantibodies also develop. It is still controversial if proinsulin rather than insulin is the primary autoantibody.METHODS: The aim of the present study was to compare the half-maximal concentration (
PurposeCombination treatments—thermal ablation (TA) and transarterial chemoembolisation (TACE) have been suggested for hepatocellular carcinoma (HCC). After TA a transient hyperemic zone appears around the ablated area, a potential target for TACE. The aim was to determine when this peri-ablational hyperemia is at its widest and most intensely perfused.Materials and methodsThis prospective study e
The thesis examines the truth and reconciliation commission in South Africa and its possibilities to act as a vehicle in the process of consolidating democracy. The norms and values that can be found in the principles and practices of the commission are scrutinized, and the means of presenting this norms to the public is also looked into. The issue of how to deal with the human rights violations o
This research approaches public administration reform in China from a domestic perspective. Whereas recognizing that the mechanisms behind the nature differ from the principle of New Public Management (NPM) of Anglo-Saxon tradition, the reform initiatives are similar. Municipal governments were encouraged to carry out NPM Reform towards governance model since 1998 to serve dual-purpose. That is st
Football supporters’ violence in Sweden is a current societal issue, which lacks experimental investigations. The current study aims to address this gap by investigating social and cognitive factors in order to better understand the mechanisms behind legitimation of violence towards supporters of the opposing team (the out-group). A football supporter and a social science student samples answered
Change towards a sustainable company is driven either by media or the company, the argument goes. It is though questionable, if companies as individual actors have an impact on the environment at all, or if they are too small in the global economy. Using the macro- economic gravity model, the size question can be answered positively, the companies do have an impact. Thus reasons why companies chan
Immunotherapy aims to enhance the immune system’s response to cancer. Different immunotherapies exist, such as cytokine therapies and immune checkpoint inhibitors. The FDA has approved immunomodulatory drugs, such as Proleukin, a recombinant IL-2 cytokine, Nivolumab, and Avelumab, which are immune checkpoint inhibitors. However, these drugs lead to side effects in patients known as immune-related
The ECJ’s judgment of 27 January 2021 in the case C-595/18 P (the ”Goldman Sachs case”) has caused a big buzz in the ever growing Private Equity sector. It confirmed the ruling of the GCEU of July 2018 case T-419/14 which in turn confirmed the Commission’s decision according to which Goldman Sachs has been held liable for an antitrust infringement committed by one of its portfolio companies. In al
The issue of corporate accountability for human rights has gained significant attention in recent years, driven by increasing globalisation, complex corporate structures, and the public’s growing awareness of the harmful effects of business activities. Alongside the rising prominence of human rights on the international agenda, the issue of environmental impacts of corporations has also become mor
Exoplanets have been observed at many stages of their host star's life, including the main-sequence (MS), subgiant and red giant branch stages. Also, polluted white dwarfs (WDs) likely represent dynamically active systems at late times. Here, we perform three-body simulations which include realistic post-MS stellar mass-loss and span the entire lifetime of exosystems with two massive planets, from
Alltsedan det kalla kriget slutade har försvarssektorn, framförallt militär logistik och försvarsmaterielanskaffning, genomgått en genomgripande transformation. Flera faktorer har bidragit till transformationen: förändringar i länders och organisationers försvars- och säkerhetspolitik; reducerade försvarsbudgetar; deltagande i fredsbevarande och fredsframtvingande operationer; erfarenheter från deSince the ending of the Cold War, the defence sector, particularly the areas of military logistics and defence acquisition, has been undergoing a comprehensive transformation. There are several factors that explain this transformation: changes in defence and security policies for nations and organisations; reductions in defence expenditure; participation in Peace Support Operations; Lessons Learne
Popular Abstract in Swedish Det är sedan länge känt att för samma bildkvalitet kan patientstråldosen variera kraftigt mellan två olika sjukhus för en och samma röntgenundersökning. Det finns ett stort utrymme för sänkning av patientstråldosen utan att undersökningens kvalitet påverkas. Vid optimering inom röntgendiagnostik balanseras patientstråldos mot bildkvalitet. Optimeringen kräver att man haOptimisation in diagnostic radiology requires accurate methods for determination of patient absorbed dose and clinical image quality. Simple methods for evaluation of clinical image quality are at present scarce and this project aims at developing such methods. Two methods are used and further developed; fulfilment of image criteria (IC) and visual grading analysis (VGA). Clinical image quality de
Three titania polymorphs, anatase, rutile, and TiO2(B), were used as supports for vanadia. Catalysts with nominal loadings corresponding to 1.5 and 5 theoretical layers were prepared. True monolayer samples were obtained by NH3(aq)-treatment of the samples with 5 nominal vanadia layers. Prepared catalysts were characterized by chemical analysis, ESR, and high-resolution electron microscopy. It was
This book chapter discusses and evaluates four different efforts to extend human life: Normalize ageing, Optimize ageing, Retard ageing and postpone death, and Eliminate or overcome ageing and death. I suggest that improved treatment of disease and handicap at all ages should be welcomed. As a secondary effect, this may in many cases result in an extension of individual lives. However, the direct
This thesis presents investigations for the improvement of electrical contact and catalytical properties of two fungal redox enzymes, cellobiose dehydrogenase (CDH) and pyranose dehydrogenase (PDH), with electrodes and the use of the prepared electrodes as carbohydrate biosensors and in enzymatic biofuel cells. The performance of enzyme modified electrodes can be improved in two ways, by modifying
