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In business controllers’ work on budgeting, considered as a classic decision-making process in organisations, it is consistently indicated that enterprise resource planning (ERP) systems, business intelligence (BI) and spreadsheets are commonly applied to assist the process. An academic research contribution on this topic is few. Most available research concentrates on ERP systems but it mentions
Prostate cancer is the second most common cancer in men. In order to improve diagnosis and prognosis, new sensitive and specific biomarkers are needed. Tissue biomarkers carry expression and morphological information of the tissue where they are expressed. However their use is still limited by technological problems, lack of standardized procedures and inadequate interpretation. In this work we in
Evidence for increased calpain activity has been described in the hippocampus of rodent models of temporal lobe epilepsy. However, it is not known whether calpains are involved in the cell death that accompanies seizures. In this work, we characterized calpain activation by examining the proteolysis of calpain substrates and in parallel we followed cell death in the hippocampus of epileptic rats.
How to best measure working memory capacity is an issue of ongoing debate. Besides established complex span tasks, which combine short-term memory demands with generally unrelated secondary tasks, there exists a set of paradigms characterized by continuous and simultaneous updating of several items in working memory, such as the n-back, memory updating, or alpha span tasks. With a latent variable
Thesis purpose: The purpose of this thesis is to reveal what critical factors affect the attitude-behaviour gap when consuming green apparel online, and what aspects in retailers’ green communication strategies are perceived to have an influence on performing green consumer behaviour online. Theoretical perspective: An own illustration of a theoretical framework has emerged from the reviewed lite
This thesis explores the imagined futures of young Swedes with a focus on how they envision creating work-life balance and how they aim to divide their time between paid and unpaid work. This is done by analyzing written accounts of 168 upper secondary students from both university preparatory schools (UP) and vocational schools (VO) in a middle-sized town in Sweden. Three top-level strategies for
Sustainable public procurement indicates that procurement is about more than just saving money. Other important interests such as social and environmental considerations can be promoted through public procurement. Thus, the Member States may use their purchasing power to procure goods and services that foster innovation, respect the environment and combat climate change while improving employment,
S100A8 and S100A9 are Ca(2+)-binding proteins that are associated with acute and chronic inflammation and cancer. They form predominantly heterodimers even if there are data supporting homodimer formation. We investigated the stability of the heterodimer in myeloid and S100A8/S100A9 over-expressing COS cells. In both cases, S100A8 and S100A9 proteins were not completely degraded even 48 hrs after
Overcrowded units, excessive waiting lists and overstrained personell. Add an aging population and you have some of the challenges facing the Swedish health care system. Change is needed at multiple levels and it needs the involvement of a wide variety of actors. Some researchers suggest that many of the current change efforts fails to honor the complexity of health care organizations. In our the
Osteoporosis is characterized by reduced bone mineral density (BMD) and increased fracture risk. Fat mass is a determinant of bone strength and both phenotypes have a strong genetic component. In this study, we examined the association between obesity associated polymorphisms (SNPs) with body composition, BMD, Ultrasound (QUS), fracture and biomarkers (Homocysteine (Hcy), folate, Vitamin D and Vit
SIK2 (salt-inducible kinase 2) is a member of the AMPK (AMP-activated protein kinase) family of kinases and is highly expressed in adipocytes. We investigated the regulation of SIK2 in adipocytes in response to cellular stimuli with relevance for adipocyte function and/or AMPK signalling. None of the treatments, including insulin, cAMP inducers or AICAR (5-amino-4-imidazolecarboxamide riboside), a
Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African ancestry compared to women of European ancestry. In search of common risk alleles for ER-negative breast cancer, we combined genome-wide association study (GWAS) data from women of African ancestry (1,004 ER-negative cases and 2,745 controls) and European ancestry (1,718 ER-negative cases and 3,670 controls)
Tasquinimod is an orally active antiangiogenic drug that is currently in phase III clinical trials for the treatment of castration-resistant prostate cancer. However, the target of this drug has remained unclear. In this study, we applied diverse strategies to identify the histone deacetylase HDAC4 as a target for the antiangiogenic activity of tasquinimod. Our comprehensive analysis revealed allo
The general population is exposed to cadmium from food and smoking. Cadmium is a widely spread toxic pollutant that seems to be associated with cardiovascular diseases, although little is known if it contributes to the occurrence of atherosclerotic plaques and the process whereby plaques become vulnerable and are prone to rupture. We tested the hypotheses that cadmium exposure is associated not on
Dator- och TV-spel är relativt nyligen introducerade och komplext utformade verk, vilket innebär en utmaning avseende upphovsrättsligt skydd. I huvudsak består ett sådant spel av ett flertal olika upphovsrättsliga alster, inkluderande programvaran, som är oupplösligt sammansatta i en och samma produkt. Detta leder till att den upphovsrättsliga klassificeringen varierar beroende på aktuell jurisdikThe video game poses a challenge in terms of copyright protection due to the complexity and novelty of its nature, in essence being comprised of multiple copyrightable elements, resulting in jurisdictionally diverse legal classification and harmonisation within the EU is not yet achieved. As the varying options of copyright classification of video game affects the applicability of EU anti-circumve
In this study, the wide area of cultural integration politics is approached. Departing from a theoretical fusion between constructivist post-colonialism and liberal cosmopolitanism, the study investigates the approach to culture that is found within the integration strategies of multiculturalism and assimilation, repsectively. By employing two stylized ideal-types and applying them to a political
