Filetype
Galectin-3 is a beta-galactoside-binding mammalian lectin that is one of a 15-member galectin family that can bind several cell surface glycoproteins via its carbohydrate recognition domain (CRD). As a result, it can influence a range of cellular processes including cell activation, adhesion and apoptosis. Galectin-3 has been implicated in various diseases, including fibrotic disorders and cancer,
Non-negative matrix factorization (NMF) is a relatively new approach to analyze gene expression data that models data by additive combinations of non-negative basis vectors (metagenes). The non-negativity constraint makes sense biologically as genes may either be expressed or not, but never show negative expression. We applied NMF to five different microarray data sets. We estimated the appropriat
Cognitive behavioral therapy (CBT) is an efficacious therapy for youth anxiety disorders. Caregivers are key stakeholders in youth therapy, and their feedback on treatment can help to inform intervention personalization. This mixed-methods study applied a systematic inductive thematic analysis to identify themes among most- and least-liked CBT features reported by caregivers using open-ended respo
Sustainability scholars increasingly recognize that policy mixes can positively impact socio-technical transitions. However, the temporal dimension of policy interventions remains under-researched, especially in the context of early transition dynamics that typically emerge in niche contexts. In this article, we explore how policy sequencing can play a key role in supporting the scaling-up of earl
PURPOSE: To present Swedish Macula Register (SMR) data regarding treatment of neovascular age-related macular degeneration (AMD) in clinical practice since 2008.METHODS: A retrospective register-based study was conducted. Evaluation of baseline demographics, visual outcome and number of injections during this period is presented.RESULTS: Mean age at diagnosis was 79 ± (SD) 8 years; 65% were female
Background: To date, the estimated radiation-absorbed dose to organs and tissues in patients undergoing diagnostic examinations in nuclear medicine is derived via calculations based on models of the human body and the biokinetic behaviour of the radiopharmaceutical. An internal dosimetry computer program, IDAC-Dose2.1, was developed based on the International Commission on Radiological Protection
This article aims to contextualise the development of the Code of Ethics for Professional Accountants by the International Federation of Accountants (IFAC) between 1977 and 2006. Drawing on transnational regulation literature, an extensive review of archival documents was conducted. The analysis unfolds the development of the Code in an increasingly complex regulatory environment, revealing the dy
In the last decade, museums that were established in the 20th century by immigrants from the five Nordic countries have become increasingly concerned with broadening their audiences and more actively engaging their visitors. Efforts to do this have varied from offering traveling exhibitions produced in the Nordic countries, film programs, festivals, concert series, cocktail hours, culinary confere
To make well-informed decisions on the implementation of solar energy on roofs within the urban environment, a new method was developed and described that could support such decision-making. This method takes both the mutual shading and shading from external objects into account. The method consists of the following six steps: 1) construction of the scene, 2) performance of annual solar irradiatioTo make well-informed decisions on the implementationof solar energy on roofs within the urban environment, anew method was developed and described that couldsupport such decision-making. This method takes both themutual shading and shading from external objects intoaccount. The method consists of the following six steps:1) construction of the scene, 2) performance of annualsolar irradiation analy
The sparse number of high-resolution human membrane protein structures severely restricts our comprehension of molecular physiology and ability to exploit rational drug design. In the search for a standardized, cheap and easily handled human membrane protein production platform, we thoroughly investigated the capacity of S. cerevisiae to deliver high yields of prime quality human AQPs, focusing on
Objectives: The behavioural experience method has been extensively used in the literature for the measurement of potential bullying behaviours at work. However, this approach presents limitations when used to classify respondents as targets or non-targets of workplace bullying. Therefore, the present study aimed to: (i) identify optimal cut-off points, reflecting a possible subjectively experience
During 2015, the Relativistic Heavy Ion Collider (RHIC) provided collisions of transversely polarized protons with Au and Al nuclei for the first time, enabling the exploration of transverse-single-spin asymmetries with heavy nuclei. Large single-spin asymmetries in very forward neutron production have been previously observed in transversely polarized p+p collisions at RHIC, and the existing theo
Background: Recent randomized trials demonstrated that laparoscopic lavage compared with resection for Hinchey III perforated diverticulitis was associated with similar mortality, less stoma formation but a higher rate of early reintervention. The aim of this study was to compare 1-year outcomes in patients who participated in the randomized Scandinavian Diverticulitis (SCANDIV) trial. Methods: Be
This work presents the development of a two-moment cloud microphysics scheme within version 5 of the NASA Goddard Earth Observing System (GEOS-5). The scheme includes the implementation of a comprehensive stratiform microphysics module, a new cloud coverage scheme that allows ice supersaturation, and a new microphysics module embedded within the moist convection parameterization of GEOS-5. Compreh
AbstractSeattle is currently the fastest growing city in the United States attracting a large pool of young international professionals – many of whom are working in the IT industry. However, Seattle is also home to a large Nordic community, immigrants once attracted by the agricultural, forestry, and fishing industries. At present however, the city is pulling in a highly educated young Nordic pop
The negative effects of transport in terms of pollution, congestion and climate change has urged the need for higher shares of cleaner and more efficient modes of transport, especially in urban settings. While new technologycan solve some of these issues, behaviour changes has also been identified as an important factor to achieve a modal shift from cars to walking, cycling or public transport. Th
The randomised phase III clinical trial Checkmate-214 showed a survival superiority for the combination of ipilimumab and nivolumab when compared with the previous standard of care in first-line metastatic/advanced clear cell renal cell carcinoma (RCC) (Escudier B, Tannir NM, McDermott DF, et al. CheckMate 214: efficacy and safety of nivolumab plus ipilimumab vs sunitinib for treatment-naïve advan
© 2017 Metal cutting simulations have become an important part of cutting tool design and the research in the field in general. One of the most important aspects of modeling is the accuracy of the tool geometry. 3D microscopy is used for measuring the tool edge radius with good accuracy. However, especially with sharp tools, i.e. small tool edge radii, the measurements, no matter how accurate, are
