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To assess the role of CHCHD2 variants in patients with Parkinson disease (PD) and Lewy body disease (LBD) in Caucasian populations.

Popular Abstract in Swedish Tillväxtfaktorer påverkar signaler mellan celler i hjärnan Människors hjärnor innehåller flera miljarder hjärnceller, vilka är förutsättningen för vårt beteende, våra känslor och våra tankar. Hjärncellerna bildar kontakter, synapser, med varandra. Genom dessa överförs signaler från en cell till en annan. Varje cell kontaktar en mängd andra celler, både sådana med liknanThe neurotrophins, notably brain-derived neurotrophic factor (BDNF) and neurotrophin 3 (NT3), modulate synaptic transmission and synaptic plasticity in the adult mammalian brain. Recent data suggest that neurotrophins might be mediators of activity-dependent synaptic plasticity. Such plasticity is believed to be a cellular correlate for important processes like learning, but also for diseases, for

BACKGROUND: Maternally derived duplications of the 15q11-q13 region are the most frequently reported chromosomal aberrations in autism spectrum disorders (ASD).Prader-Willi and Angelman syndromes, caused by 15q11-q13 deletions or abnormal methylation of imprinted genes, are also associated with ASD. However, the prevalence of these disorders in ASD is unknown. The aim of this study was to assess t

Computers are increasingly used for implementing controlalgorithms in safety-critical embedded applications, such asengine control, braking control and flight surfacecontrol. Addressing the consequent coupling of control performancewith computer related errors, this paper develops a composite computerdependability/control theory methodology for analyzing the effectsdata errors have on control syst

We present an abundance analysis of the very metal-poor, carbon-enhancedstar CS 29497-030. Our results indicate that this unusually hot turnoffstar (T_eff = 6650 K, log g = 3.5) has a metallicity [Fe/H] =-2.8, and exhibits large overabundances of carbon ([C/Fe] = +2.38),nitrogen ([N/Fe] = +1.88), and oxygen ([O/Fe] = +1.67). This star alsoexhibits a large enhancement in its neutron-captu

Currently, a single ion hit facility, for irradiation of single cells with single, light MeV ions is under development at the Lund Nuclear Microprobe. In this paper, a novel approach to the ion detection issue is presented. A silicon detector, a type utilized at other facilities for post-cell ion detection, has been investigated as a possible option for pre-cell hit detection. If proven successful

A constitutive model for diffusionless phase transitions in elastoplastic materials undergoing large deformations is developed. The model takes basic thermodynamic relations as its starting point and the phase transition is treated through an internal variable (the phase fractions) approach. The usual yield potential is used together with a transformation potential to describe the evolution of the

Clay minerals cannot only give information on sedimentary depositional environment but also the climate regime under which sediment was weathered. The successions of non-marine to marine Middle and Late Jurassic strata of the East European Platform show upwards increasing contents of smectite and decreasing contents of kaolinite. There is also an increasing smectite vs. kaolinite ratio laterally,

BACKGROUND/AIMS: Endoscopic sphincterotomy is an established treatment of retained or recurrent common bile duct calculi after cholecystectomy and in the majority of patients with an intact gallbladder. In order to identify patients ultimately requiring additional endoscopic procedures or surgery, factors predictive of decreased endoscopic bile duct clearance were sought. MATERIAL AND METHODS: Bet

Background: In most clubfoot studies, the outcome instruments used are designed to evaluate classification or long-term cross-sectional results. Variables deal mainly with factors on body function/structure level. Wide scorings intervals and total sum scores increase the risk that important changes and information are not detected. Studies of the reliability, validity and responsiveness of these i

High-spin terminating bands in heavy nuclei were first identified in nuclei around Er-158(90). While examples of special terminating states have been identified in a number of erbium isotopes, almost nothing is known about the states lying beyond band termination. In the present work the high-spin structure of Er-157 has been studied using the Gammasphere spectrometer. The subject of triaxial supe