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doi:10.1016/S1044-7431(03)00097-6 A transplantation study of expanded human embryonic forebrain precursors: evidence for selection of a specific progenitor population Malin Parmar,* Charlotta Skogh, and Ulrica Englund1 Wallenberg Neuroscience Center, BMC A11, Section of Neurobiology, Lund University, SE-221 84 Lund, Sweden Received 2 January 2003; revised 12 March 2003; accepted 17 March 2003 Abst
BACKGROUND: Prediction models for sentinel lymph node (SLN) status could potentially substitute surgical axillary staging in patients with early breast cancer. Several imaging modalities have been used with various feature extraction and selection approaches. This systematic review and meta-analysis aimed to evaluate prediction models for SLN status based on breast imaging in patients with early b
BACKGROUND: The medial temporal lobe (MTL) is hypothesized to be relatively spared in early-onset Alzheimer's disease (EOAD). Yet, detailed examination of MTL subfield volumes and drivers of atrophy in amnestic EOAD is lacking.METHODS: BioFINDER-2 participants with memory impairment, abnormal amyloid-β status and tau-PET were included. Forty-one EOAD individuals aged ≤65 years and, as comparison,
Optical imaging utilize light to analyze biological tissues in detail, non-invasively and without harmful radiation. Examples include ultrasound optical tomography and photoacoustic imaging; both use a limited number of wavelengths. Diffuse reflectance spectroscopy, another optical technique, covers a continuous wavelength range, but without generating an image. This study focuses on extended-wave
The capabilities of ultrasound optical tomography (UOT) is investigated through Monte Carlo simulations on realistic breast tissue phantoms constructed using the OpenVCT platform. This work indicates that UOT is a method capable of distinguishing malignant tumor tissue from benign glandular tissue deep inside the breast, despite the natural variations of adipose and glandular compartments within a
Rationale: Knowledge regarding the prevalence and shared and unique characteristics of the restrictive spirometric pattern (RSP) and preserved ratio impaired spirometry (PRISm) is lacking for a general population investigated with post-bronchodilator spirometry and computed tomography of the lungs. Objectives: To investigate shared and unique features for RSP and PRISm. Methods: In the Swedish CAr
Background Indications with poor T-cell infiltration or deficiencies in T-cell priming and associated unresponsiveness to established immunotherapies represent an unmet medical need in oncology. CD40-targeting therapies designed to enhance antigen presentation, generate new tumor-specific T cells, and activate tumor-infiltrating myeloid cells to remodel the tumor microenvironment, represent a prom
Russ et al. show that human astrocytes adopt different reactive immune phenotypes when exposed to either TNF-α or alpha-synuclein fibrils, which are exogenous stressors that compete to drive the astrocyte immune reactive response. They also show that PARK2-variant-containing astrocytes exhibit an exacerbated response to the stressors, accompanied by bioenergetic defects.
This study presents how sequential infiltration synthesis of trimethyl aluminium and water into a carbohydrate-based block copolymer was used to enable pattern transfer of 6 nm half-pitch horizontal cylinders into silicon. Specular neutron reflectometry measurements of poly(styrene)-block-maltoheptaose self-assembled into horizontal cylinders indicate an increasing content of alumina after each se
Background: In contrast to typical measures employed to assess outcomes in healthcare such as mortality or recovery rates, it is difficult to define which specific outcomes of care are the most important in caring for dying individuals. Despite a variety of tools employed to assess different dimensions of palliative care, there is no consensus on a set of core outcomes to be measured in the last d
A series of phosphorylated test peptides was studied by electron capture dissociation Fourier transform ion cyclotron resonance mass spectrometry (ECD FT-ICR MS). The extensive ECD-induced fragmentation made identification of phosphorylation sites for these peptides straightforward. The site(s) of initial phosphorylation of a synthetic peptide with a sequence identical to that of the phosphorylati
Huntington disease (HD) is an autosomal dominant neurodegenerative disorder caused by expanded CAG repeats in the huntingtin gene (HTT). Although mutant HTT is expressed during embryonic development and throughout life, clinical HD usually manifests later in adulthood. A number of studies document neurodevelopmental changes associated with mutant HTT, but whether these are reversible under therapy
The interaction of two confined coaxial jets has been studied using Computational Fluid Dynamics. Annular jet flows over 8 flat blade swirl generator. Numerical simulation uses RNG k- ϵ turbulence model. These models are suitable for turbulent swirl dominated flows. Intermediate swirl injector has been simulated and the flow patterns for non-reactive and reactive cases are contrasted. Low swirling
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as environmental assessment. Repeated dose toxicity was determined to have the most conservative systemic
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential as well as environmental safety. Repeated dose, developmental, and reproductive toxicities were determined to have
The use of this material under current use conditions is supported by the existing information. This material was evaluated for Genotoxicity, Repeated Dose Toxicity, Developmental Toxicity, Reproductive Toxicity, Local Respiratory Toxicity, Phototoxicity, Skin Sensitization potential as well as Environmental assessment. Repeated Dose Toxicity was determined to have the most conservative systemic e
The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential as well as environmental assessment. Repeated Dose Toxicity was determined to have the most conservative systemic e
The use of this material under current use conditions is supported by the existing information. This material was evaluated for Genotoxicity, Repeated Dose Toxicity, Developmental Toxicity, Reproductive Toxicity, Local Respiratory Toxicity, Phototoxicity, Skin Sensitization potential as well as Environmental assessment. Reproductive toxicity was based on the Threshold of Toxicological Concern (TTC
The use of this material under current use conditions is supported by the existing information. This material was evaluated for Genotoxicity, Repeated Dose Toxicity, Developmental Toxicity, Reproductive Toxicity, Local Respiratory Toxicity, Phototoxicity, Skin Sensitization potential as well as Environmental assessment. Repeated dose toxicity was determined to have the most conservative systemic e
