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Effects of long-term oxygen therapy on acute exacerbation and hospital burden : the national DISCOVERY study

BACKGROUND: Long-term oxygen therapy (LTOT) improves survival in patients with chronic severe resting hypoxaemia, but effects on hospitalisation are unknown. This study evaluated the potential impact of starting LTOT on acute exacerbation and hospital burden in patients with chronic obstructive pulmonary disease (COPD), interstitial lung disease (ILD) and pulmonary hypertension (PH).METHODS: Longi

Exceptional points in anisotropic photonic structures : From non-Hermitian physics to possible device applications

We demonstrate that exceptional points exist in fully transparent, optically "effectively" biaxial, anisotropic micro-cavities, fabricated using an uniaxial cavity material with its axis inclined to the Bragg mirror growth direction. This is similar to the existence of singular (optic) axes in absorbing biaxial crystals, but the lack of time reversal symmetry is mediated by the mode broadening, i.

The Swedish Environmental Classification and Information System for Pharmaceuticals - An empirical investigation of the motivations, intentions and expectations underlying its development and implementation

In 2005 the Swedish Association of the Pharmaceutical Industry (LIF) initiated a national environmental classification and information system for pharmaceuticals. This investigation reports the results from a survey, conducted among the persons involved in the start-up process. The aim of this study is to generate knowledge contributing to the clarification of the motivations, expectations, and in

Smoking and home oxygen therapy : a review and consensus statement from a multidisciplinary Swedish taskforce

Background: Home oxygen therapy (HOT) improves survival in patients with hypoxaemic chronic respiratory disease. Most patients evaluated for HOT are former or active smokers. Oxygen accelerates combustion and smoking may increase the risk of burn injuries and fire hazards; therefore, it is considered a contraindication for HOT in many countries. However, there is variability in the practices and p

Dual-binary phase gratings for x-ray interferometry

X-ray phase-contrast imaging by grating interferometry has in the past decades been established both at synchrotron radiation sources and at conventional x-ray tubes. Due to the sensitivity to x-ray phase shifting, contrast in soft tissue has been improved significantly and the possibilities to do virtual histology of tissue biopsies are being pioneered. Constraints in the design of a grating inte

Social Injustice, Group Membership and Epistemic Trust in Robots

This paper focuses on the intersection of social dynamics, knowledge production, and the implementation of identity features in robotic platforms. Concentrating on the concept of epistemic injustice, particularly in the context of trust, the study highlights the potential for justified distrust based on experienced injustice. The incorporation of social identity features, such as gender, signals g

Degradation of the microbicide 2-(thiocyanomethylthio) benzothiazole by direct photolysis

Microbicides in the leather industries are employed to avoid the biodeterioration of the hides by microorganisms. This problem may lead to harmful characteristics to the end product such as stains, roughness and decrease mechanical properties of leather. Therefore, microbicides like the 2-(thiocyanomethylthio) benzothiazole (TMCTB) are applied in distinct steps of the tanning process as alternativ

Death rituals and quality of life of bereaved relatives during the COVID-19 pandemic : Results of the observational CO-LIVE study

Grief is a normal reaction after the death of a loved one. Death rituals are an integral part of the mourning processes. Not being able to carry out death rituals can affect relatives' quality of life. The aim was to evaluate death rituals during COVID-19 and their association with relatives' quality of life. In a Swedish nation-wide study relatives to persons who died during the COVID-19-pandemic

Developing a core outcome set for gender-affirming healthcare in transgender and gender diverse adults in Sweden using the Delphi approach : A study protocol

Introduction Despite an increasing amount of research related to gender-affirming treatment (GAT) outcomes among transgender and gender-diverse (TGD) people (ie, people who experience discomfort or distress in the misalignment between their gender and sex assigned at birth) in recent years, the evidence base for current recommendations is suboptimal. One contributing factor is the heterogeneity in

Association between obstructive sleep apnoea and cancer : a cross-sectional, population-based study of the DISCOVERY cohort

Objectives Nocturnal hypoxia in obstructive sleep apnoea (OSA) is a potential risk factor for cancer. We aimed to investigate the association between OSA measures and cancer prevalence in a large national patient cohort. Design Cross-sectional study. Settings 44 sleep centres in Sweden. Participants 62 811 patients from the Swedish registry for positive airway pressure (PAP) treatment in OSA, link

Breathlessness and exercise performance to predict mortality in long-term oxygen therapy - The population-based DISCOVERY study

BACKGROUND: Patients with chronic respiratory failure treated with long-term oxygen therapy (LTOT) often have severe breathlessness, impaired exercise performance, and high but variable mortality that is difficult to predict. We aimed to evaluate breathlessness and exercise performance upon starting LTOT as predictors of overall and short-term mortality.METHODS: This was a longitudinal, population

Impact of trigeminal nerve and/or olfactory nerve stimulation on activity of human brain regions involved in the perception of breathlessness

Breathlessness is a centrally processed symptom, as evidenced by activation of distinct brain regions such as the insular cortex and amygdala, during the anticipation and/or perception of breathlessness. Inhaled L-menthol or blowing cool air to the face/nose, both selective trigeminal nerve (TGN) stimulants, relieve breathlessness without concurrent improvements in physiological outcomes (e.g., br

Reference equations for breathlessness during incremental cycle exercise testing

Background Exertional breathlessness is commonly assessed using incremental exercise testing (IET), but reference equations for breathlessness responses are lacking. We aimed to develop reference equations for breathlessness intensity during IET. Methods A retrospective, consecutive cohort study of adults undergoing IET was carried out in Sweden. Exclusion criteria included cardiac or respiratory

Oral Methadone versus Morphine IR for Patients with Cervical Cancer and Neuropathic Pain : A Prospective Randomised Controlled Trial

Objectives: In India, cervical cancer is the most common cancer among women and makes up for up to 29% of all registered cancer in females. Cancer-related pain is one of the major distressing symptoms for all cancer patients. Pain is characterised as somatic or neuropathic, and the total pain experience is often mixed. Conventional opioids are the backbone of analgesic treatment but are most often

A Proactive Cloud Application Auto-Scaler using Reinforcement Learning

This work explores the use of reinforcement learning to design a proactive cloud resource auto-scaler that is able to predict usage across a distributed microservice application. The focus is on serving time-sensitive workloads, e.g., industrial automation, connected XR/VR (eXtended Reality/Virtual Reality), etc., where each job has a deadline and there is some cost associated with missing a deadl

Chemical analysis of combustion products from a high-pressure gas turbine combustor rig fueled by jet A1 fuel and a flscher-tropsch-based fuel

A comparative experimental investigation has been performed, comparing the emissions from a synthetic jet fuel and from Jet AI. In the investigation, the unburned hydrocarbons were analyzed chemically and the regulated emissions of NOX, CO and HC were measured. All combustion tests were performed under elevated pressures in a gas turbine combustor rig. A Swedish company, Oroboros AB, has developed

Elizabeth Bennet vs Katniss Everdeen

Analys av hjältinnan utifrån ett feministiskt perspektiv. En jämförelse mellan Jane Austens hjältinna Elizabeth Bennet i Pride and Prejudice och Suzanne Collins hjältinna Katniss Everdeen i The Hunger Games.Analysis of the heroine from a feminist perspective. A comparison between Jane Austen's heroine Eliabeth Bennet in Pride and Prejudice and Suzanne Collins' heroine Katniss Everdeen in The Hunger Games.

The English Rule v. The American Rule - En komparativ studie i hur rättegångskostnader fördelas i dispositiva tvistemål i Sverige och USA

I det svenska rättssystemet fördelas rättegångskostnader i tvistemål i enlighet med The English Rule. Huvudregeln är att den förlorande parten, utöver att denne får stå sina egna rättegångskostnader, åläggs att betala motpartens kostnader. Regler för hur rättegångskostnader fördelas i det svenska rätts-systemet återfinns framför allt i 18 kap. rättegångsbalken. Till huvudregeln finns ett flertal uIn the Swedish legal system, litigation expenses are distributed according to The English Rule. The rule is that the losing party of the trial is obliged to pay the opposing party’s litigation expenses, as well as its own. Distribution of litigation expenses is mainly regulated in the 18th chapter of the Code of Judicial Procedure (rättegångsbalken). The English Rule is not without exceptions. Th