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On the Selection of Methods and Tools for Analysis of Heat and Power Plants

Popular Abstract in Swedish Affärsklimatet för dagens energimarknad har varit händelserik de senaste två decennierna med introduktaion av den avreglerade elmarknaden och den ökade vikten av miljöfrågor vid design och inköp av energirelaterade anläggningar. Detta har bidragit med krav om nya analyskriterier, vilka inte bara påverkar den tekniska utformningen av komponenter och system, utan även tilThe business climate of the energy market has been eventful over the last two decades, particularly with the introduction of the deregulated electricity market and promotion of environmental issues. This has subsequently lead to new analysis criteria, influencing both technology requirements and production costs. To be able to manage all the questions that have arisen from this the knowledge of th

Population-based incidence rate of inpatient and outpatient surgical procedures in a high-income country

Background: The WHO and the World Bank ask countries to report the national volume of surgery. This report describes these data for Sweden, a high-income country. Methods: In an 8-year population-based observational cohort study, all inpatient and outpatient care in the public and private sectors was detected in the Swedish National Patient Register and screened for the occurrence of surgery. The

The Role of PTEN Loss in Immune Escape, Melanoma Prognosis and Therapy Response

Checkpoint blockade therapies have changed the clinical management of metastatic melanoma patients considerably, showing survival benefits. Despite the clinical success, not all patients respond to treatment or they develop resistance. Although there are several treatment predictive biomarkers, understanding therapy resistance and the mechanisms of tumor immune evasion is crucial to increase the f

Gold impurity concentration in vapor-liquid-solid grown GaAs nanowires

Gold particles are commonly used as catalysts in the vapor-liquid-solid (VLS) growth of GaAs nanowires, but the incorporation of gold into the nanowires can negatively affect their electronic and optical properties. In this work, we investigate the equilibrium concentration of Au in GaAs nanowires using density functional theory calculations combined with thermodynamically assessed chemical potent

Stealing Knowledge in a Landscape of Learning: Conceptualizations of Jazz Education

Theoretical approaches to learning in practice-based jazz improvisation contexts include situated learning and ecological perspectives. This article focuses on how interest-driven, self-sustaining jazz learning activities can be matched against the concepts of stolen knowledge (Brown & Duguid, 1996) and landscape of learning (Bjerstedt, 2014). Based on an extensive interview study with SwedishTheoretical approaches to learning in practice-based jazz improvisation contexts include situated learning and ecological perspectives. This article focuses on how interest-driven, self-sustaining jazz learning activities can be matched against the concepts of stolen knowledge (Brown & Duguid, 1996) and landscape of learning (Bjerstedt, 2014). Based on an extensive interview study with Swedish

Engineered allele substitution at PPARGC1A rs8192678 alters human white adipocyte differentiation, lipogenesis, and PGC-1α content and turnover

Aims/hypothesisPPARGC1A encodes peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α), a central regulator of energy metabolism and mitochondrial function. A common polymorphism in PPARGC1A (rs8192678, C/T, Gly482Ser) has been associated with obesity and related metabolic disorders, but no published functional studies have investigated direct allele-specific effects in adipocyte bi

Precision medicine in complex diseases - : Molecular subgrouping for improved prediction and treatment stratification

Complex diseases are caused by a combination of genetic, lifestyle, and environmental factors and comprise common noncommunicable diseases, including allergies, cardiovascular disease, and psychiatric and metabolic disorders. More than 25% of Europeans suffer from a complex disease, and together these diseases account for 70% of all deaths. The use of genomic, molecular, or imaging data to develop

Meristem wall : an exploration of 3d-printed architecture

Meristem Wall is a prototype for a 3D-printed building envelope, featuring a dynamically controllable network of integrated air channels that allow a fluid and adaptive relationship between inside and outside. The wall integrates functional lighting and electricity, windows, and a custom CNC-knitted textile interior. It is fabricated through binder-jet sand 3D printing and points towards a climati

A phenome-wide comparative analysis of genetic discordance between obesity and type 2 diabetes

Obesity and type 2 diabetes are causally related, yet there is considerable heterogeneity in the consequences of both conditions and the mechanisms of action are poorly defined. Here we show a genetic-driven approach defining two obesity profiles that convey highly concordant and discordant diabetogenic effects. We annotate and then compare association signals for these profiles across clinical an

B lymphocyte specification is preceded by extensive epigenetic priming in multipotent progenitors

B lymphocyte development is dependent on the interplay between the chromatin landscape and lineage-specific transcription factors. It has been suggested that B lineage commitment is associated with major changes in the nuclear chromatin environment, proposing a critical role for lineage-specific transcription factors in the formation of the epigenetic landscape. In this report, we have used chromo

Proteomic data analysis for differential profiling of the autoimmune diseases SLE, RA, SS, and ANCA-associated vasculitis

Early and correct diagnosis of inflammatory rheumatic diseases (IRD) poses a clinical challenge due to the multifaceted nature of symptoms, which also may change over time. The aim of this study was to perform protein expression profiling of four systemic IRDs, systemic lupus erythematosus (SLE), ANCA-associated systemic vasculitis (SV), rheumatoid arthritis (RA), and Sjögren's syndrome (SS), and

Constructive friction? Exploring patterns between Educational Research and The Scholarship of Teaching and Learning

While educational research (EdR) and the Scholarship of Teaching and Learning (SoTL) are overlapping fields there remains considerable friction between the two. Shulman, (2011, p. 5), recounts a situation when an EdR colleague accused him “of contributing to the bastardization of the field by encouraging faculty members who were never trained to conduct educational or social science research to en

Implementering med hjälp av IoT(Internet of Things)

Bluvisions IoT-system har varit huvudfokus under utredningen av om IoT(Internet of Things) är lönsamt att implementera på framtidens Valmetmaskiner. Från början så skulle projektet avgränsas till pressning, kräppning och upprullning men under examensarbetets start fick Valmet svårt att hitta orsaken till varför en ny komponent hade havererat. Havereringen tros ha haft ett samband med höga vibratioBluvision’s IoT-system has been the focus during the investigation if IoT (internet of things) is something that can be implemented on future Valmet machines. From the beginning the bachelor thesis was restricted to press, creping and turn-up. During the initial phase of the bachelor theses start Valmet had problem finding out why a new component had failed. Therefore, it was more valuable for Val

Bolagsordningen och aktieägaravtalet som effektiva styrningsverktyg i ägarledda bolag - Särskilt om överlåtelseregleringar

I ägarledda bolag där aktieägare i regel också är aktiva som organledamöter är det viktigt att kunna reglera beslutsfattandet i bolaget och att ha kontrollen över ägarkretsen. Aktieägarna kan använda styrningsverktygen bolagsordningen och aktieägaravtalet för att reglera detta. Det övergripande syftet med denna uppsats är att undersöka förhållandet mellan bolagsordningen och aktieägaravtalet som sIn closely held companies, shareholders are often also involved as Board members and in these companies it is important to govern the decision-making process and the sale of shares. The Articles of Association and the Shareholders’ agreement are governing instruments and can be used for this purpose. The overall purpose of this thesis is to examine the relationship between the Article of Associati

Verklig innebörd - en tolkning av verkligheten. En utredning av innebörden och tillämpningen av "verklig innebörd" i ljuset av legalitetsprincipen.

Inom den svenska inkomstskatterätten används ibland civilrättsliga begrepp som utgångspunkt. Även om detta ofta kan ske problemfritt uppstår ibland frågan om en rättshandling på grund av omständigheterna i fallet ska beskattas enligt dess yttre form, eller om den i stället ska beskattas enligt sin verkliga innebörd. Domstolen har i vissa fall kommit att omkvalificera rättshandlingar vars innehåll Swedish tax law often utilizes concepts derived from civil law. The use of these concepts is in many cases without complications. However, occasionally, the question of how a specific transaction or other act of law should be qualified arises; should the act be legally qualified and taxed according to its form, or should it be legally qualified and taxed according to its “real meaning”. There are

Konformitetsprincipens gränsmarker - Med inriktning mot unga lagöverträdare och en sänkning av straffmyndighetsåldern

Konformitetsprincipen är den grundläggande rättsprincipen i den straffrätts-liga ansvarsläran som ger besked om att den som inte hade förmåga eller tillfälle att kunna rätta sig efter lagen inte bör bli straffrättsligt ansvarig för ett brott. Detta eftersom ett straffansvar i den situationen hade varit orätt-färdigt och meningslöst. Den som inte kunde rå för sin brottsliga gärning ska således inteThe Conformity Principle is a fundamental legal principle within the Swedish system of criminal liability that states that those who did not have capacity or opportunity to act in accordance with the criminal law should not be punished for a crime. Numerous rules and several legal principles can be derived from The Conformity Principle. The rationale behind the Conformity Principle is that it woul

Tre sensvekofenniska graniter : kontakt- och åldersrelationer samt förekomst av metasedimentära enklaver

I den svekofenniska provinsens centrala region har granitoider som är tidig-, sen-, post- och anorogena intruderat metasedimentära bergarter (Härnögnejs) av varierande metamorf grad. Fältarbetet för denna undersökning utfördes i den södra delen av ett 15 x 15 km stort och rundat sensvekofenniskt granitmassiv ca 10 km väster om Örnsköldsvik. Här förekommer tre olika graniter som i detta arbete kalIn the central region of the Svecofennian Province, granitoids related to different stages of the the Svecofennian orogeny have intruded metasediments (Härnö gneiss) of varying metamorphic grades. The fieldwork of this project was carried out in Ångermanland about ten km to the west of Örnsköldsvik. The mapping area is situated in the southern part of a 15×15 km rounded late Svecofennian multi-in

Ensemble Forecasting: A data analysis

Meteorologi är ett område som genomgick utveckling under 1900-talet. Det har gått från att vara väldigt erfarenhetsbaserat till att bestå av komplexa matematiska modeller som körs av superdatorer. Ett av de mer nyliga tilläggen är ensembleprognoser. De började användas operativt 1992 av European Centre for Medium-Range Weather Forecasts (ECMWF). En ensembleprognos är uppbyggd av ett flertal modelThis thesis covers the use of ensemble forecasts, how they work and their benefits. It will also give a brief history of weather forecasting followed by an evaluation, where ensemble mean precipitation data from the ECMWF is compared to observation data for 21 different observation stations spread across Sweden. From the evaluation, the mean has difficulty representing amounts of precipitation cor

Sound propagation through Australian forest land - With special regards to noise generated by wind turbines

Vind har blivit en alltmer accepterad källa till förnyelsebar energi och utnyttjas idag världen över. Vindenergi har fördelen av nästintill inga utsläpp av växthusgaser, men allmänheten har i vissa uttryckt oro över det buller som associeras med vindkraftverk. For att möta detta missnöje har kommuner infört föreskrifter som begränsar ljudnivåerna vid bostadshus belägna i närheten av vindkraftverk.Wind has become an increasingly accepted source of renewable energy and is currently exploited worldwide. Wind energy has the advantage of close to zero green-house gas emissions, however one of the key concerns the public has about wind farm development is noise emissions. To address these local governments have introduced noise regulations, which limit noise levels at residential buildings locat