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We evaluate the shared genetic regulation of mRNA molecules, proteins and metabolites derived from whole blood from 3029 human donors. We find abundant allelic heterogeneity, where multiple variants regulate a particular molecular phenotype, and pleiotropy, where a single variant associates with multiple molecular phenotypes over multiple genomic regions. The highest proportion of share genetic re

Animal migration has fascinated scientists and the public alike for centuries, yet migratory animals are facing diverse threats that could lead to their demise. The Anthropocene is characterised by the reality that humans are the dominant force on Earth, having manifold negative effects on biodiversity and ecosystem function. Considerable research focus has been given to assessing anthropogenic im

A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expressi

Pure hydrocarbons with shape and conjugation properties that can be switched by external stimuli is an intriguing prospect in the design of new responsive materials and single-molecule electronics. Here, we develop an oligomeric [8]annulene-based material that combines a remarkably efficient topological switching upon redox changes with structural simplicity, stability, and straightforward synthes

Outcome under-ascertainment, characterized by the incomplete identification or reporting of cases, poses a substantial challenge in epidemiologic research. While capture-recapture methods can estimate unknown case numbers, their role in estimating exposure effects in observational studies is not well established. This paper presents an ascertainment probability weighting framework that integrates

Resonant photoelectron spectroscopy (RPES) has been used to probe electronic structure properties of the closed-shell [FeII(CN)6]4− and open-shell [FeIII(CN)6]3− prototype transition metal complexes in aqueous solution. Site-selective Fe 2p (L-edge) RPES mapsprovide new insight into spin-coupling processes at the core-excited metal centers, with autoionization of [FeIII(CN)6]3− showing a dramatic

BACKGROUND: Type 2 diabetes is one of the leading causes of chronic kidney failure, which increases globally and represents a significant threat to public health. People from the Middle East represent one of the largest immigrant groups in Europe today. Despite poor glucose regulation and high risk for early-onset insulin-deficient type 2 diabetes, they have better kidney function and lower rates

Background: The association between protein intake and prostate cancer risk remains unclear. Aims: To prospectively investigate the associations of dietary intakes of total protein, protein from different dietary sources, and amino acids with prostate cancer risk and mortality. Methods: In 131,425 men from the European Prospective Investigation into Cancer and Nutrition, protein and amino acid int

In the present study, we apply deterministic chaos theory to investigate nonlinear dynamics in monthly precipitation at Mokpo, Korea, after wavelet decomposition. The wavelet transform is used not only for removal of noise but also for extraction of low and high frequency components in the data, representing low-dimensional dynamics. In order to determine an appropriate decomposition level for the

We report on local nowcasting (short-term forecasting) of coronavirus disease (COVID-19) hospitalizations based on syndromic (symptom) data recorded in regular healthcare routines in Östergötland County (population ≈465,000), Sweden, early in the pandemic, when broad laboratory testing was unavailable. Daily nowcasts were supplied to the local healthcare management based on analyses of the time la

Background: Lifestyle choices, metformin, and dietary supplements may prevent GDM, but the effect of intervention characteristics has not been identified. This review evaluated intervention characteristics to inform the implementation of GDM prevention interventions. Methods: Ovid, MEDLINE/PubMed, and EMBASE databases were searched. The Template for Intervention Description and Replication (TIDieR

Popular Abstract in Swedish Affärsklimatet för dagens energimarknad har varit händelserik de senaste två decennierna med introduktaion av den avreglerade elmarknaden och den ökade vikten av miljöfrågor vid design och inköp av energirelaterade anläggningar. Detta har bidragit med krav om nya analyskriterier, vilka inte bara påverkar den tekniska utformningen av komponenter och system, utan även tilThe business climate of the energy market has been eventful over the last two decades, particularly with the introduction of the deregulated electricity market and promotion of environmental issues. This has subsequently lead to new analysis criteria, influencing both technology requirements and production costs. To be able to manage all the questions that have arisen from this the knowledge of th

Meteorologi är ett område som genomgick utveckling under 1900-talet. Det har gått från att vara väldigt erfarenhetsbaserat till att bestå av komplexa matematiska modeller som körs av superdatorer. Ett av de mer nyliga tilläggen är ensembleprognoser. De började användas operativt 1992 av European Centre for Medium-Range Weather Forecasts (ECMWF). En ensembleprognos är uppbyggd av ett flertal modelThis thesis covers the use of ensemble forecasts, how they work and their benefits. It will also give a brief history of weather forecasting followed by an evaluation, where ensemble mean precipitation data from the ECMWF is compared to observation data for 21 different observation stations spread across Sweden. From the evaluation, the mean has difficulty representing amounts of precipitation cor

Konformitetsprincipen är den grundläggande rättsprincipen i den straffrätts-liga ansvarsläran som ger besked om att den som inte hade förmåga eller tillfälle att kunna rätta sig efter lagen inte bör bli straffrättsligt ansvarig för ett brott. Detta eftersom ett straffansvar i den situationen hade varit orätt-färdigt och meningslöst. Den som inte kunde rå för sin brottsliga gärning ska således inteThe Conformity Principle is a fundamental legal principle within the Swedish system of criminal liability that states that those who did not have capacity or opportunity to act in accordance with the criminal law should not be punished for a crime. Numerous rules and several legal principles can be derived from The Conformity Principle. The rationale behind the Conformity Principle is that it woul

I denna uppsats kommer det skatterättsliga neutralitetsperspektivet hos fastighetstransaktioner att diskuteras och särskilt fokus kommer att ligga på stämpelskatten. De fastighetstransaktioner som tas upp är överlåtelse, bolagsförvärv och fastighetsbildning. Det moderna svenska skattesystemet bygger på nationalekonomiska teorier och de senaste 30 åren har fokus legat på att få ett effektivt skattIn this essay, the tax neutrality perspective of property transactions will be discussed and a special focus will be put on stamp duty. The real estate transactions which are covered in the essay are transfers, acquisitions and “fastighetsbildning”. The modern Swedish tax system is based on economic theories and in the last 30 years the focus has been put on getting an efficient tax system, wher

Bluvisions IoT-system har varit huvudfokus under utredningen av om IoT(Internet of Things) är lönsamt att implementera på framtidens Valmetmaskiner. Från början så skulle projektet avgränsas till pressning, kräppning och upprullning men under examensarbetets start fick Valmet svårt att hitta orsaken till varför en ny komponent hade havererat. Havereringen tros ha haft ett samband med höga vibratioBluvision’s IoT-system has been the focus during the investigation if IoT (internet of things) is something that can be implemented on future Valmet machines. From the beginning the bachelor thesis was restricted to press, creping and turn-up. During the initial phase of the bachelor theses start Valmet had problem finding out why a new component had failed. Therefore, it was more valuable for Val

I ägarledda bolag där aktieägare i regel också är aktiva som organledamöter är det viktigt att kunna reglera beslutsfattandet i bolaget och att ha kontrollen över ägarkretsen. Aktieägarna kan använda styrningsverktygen bolagsordningen och aktieägaravtalet för att reglera detta. Det övergripande syftet med denna uppsats är att undersöka förhållandet mellan bolagsordningen och aktieägaravtalet som sIn closely held companies, shareholders are often also involved as Board members and in these companies it is important to govern the decision-making process and the sale of shares. The Articles of Association and the Shareholders’ agreement are governing instruments and can be used for this purpose. The overall purpose of this thesis is to examine the relationship between the Article of Associati

I den svekofenniska provinsens centrala region har granitoider som är tidig-, sen-, post- och anorogena intruderat metasedimentära bergarter (Härnögnejs) av varierande metamorf grad. Fältarbetet för denna undersökning utfördes i den södra delen av ett 15 x 15 km stort och rundat sensvekofenniskt granitmassiv ca 10 km väster om Örnsköldsvik. Här förekommer tre olika graniter som i detta arbete kalIn the central region of the Svecofennian Province, granitoids related to different stages of the the Svecofennian orogeny have intruded metasediments (Härnö gneiss) of varying metamorphic grades. The fieldwork of this project was carried out in Ångermanland about ten km to the west of Örnsköldsvik. The mapping area is situated in the southern part of a 15×15 km rounded late Svecofennian multi-in

Inom den svenska inkomstskatterätten används ibland civilrättsliga begrepp som utgångspunkt. Även om detta ofta kan ske problemfritt uppstår ibland frågan om en rättshandling på grund av omständigheterna i fallet ska beskattas enligt dess yttre form, eller om den i stället ska beskattas enligt sin verkliga innebörd. Domstolen har i vissa fall kommit att omkvalificera rättshandlingar vars innehåll Swedish tax law often utilizes concepts derived from civil law. The use of these concepts is in many cases without complications. However, occasionally, the question of how a specific transaction or other act of law should be qualified arises; should the act be legally qualified and taxed according to its form, or should it be legally qualified and taxed according to its “real meaning”. There are

Postadress Box 8084 200 10 Malmö Besöksadress Bergsgatan 31B, Malmö Telefon 040-325400 E-post kanslik@kanslik.lu.se Dekan Riktlinjer för registrering av forskningsinformation i LUCRIS vid Konstnärliga fakulteten Bakgrund LUCRIS (Lund University Current Research Information System) är Lunds universitets system för forskningsinformation. Enligt rektorsbeslut ska all forskande personal från och med s

https://www.konstnarliga.lu.se/sites/konstnarliga.lu.se/files/2024-04/Riktlinjer%20fo%CC%88r%20registrering%20av%20forskningsinformation%20i%20LUCRIS%20vid%20Konstna%CC%88rliga%20fakulteten-signed%20(1).pdf - 2026-06-05