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The autoimmune checkpoint during B cell maturation eliminates self-antigen reactive specificities from the mature B cell repertoire. However, an exception to this rule is illustrated by B-1 cells, an innate-like self-reactive B cell subset that is positively selected into the mature B cell pool in a self-antigen-driven fashion. The mechanisms by which B-1 cells escape central tolerance have puzzle
Scholarly and practitioner interest in the topic of authentic leadership has grown dramatically over the past two decades. Running parallel to this interest, however, have been a number of concerns regarding the conceptual and methodological underpinnings for research on the construct. In this exchange of letters, the cases for and against the current authentic leadership theory are made. Through
This article examines how a firm's willingness to make trade-offs that favour sustainability over commercial goals attenuates the relationship between firm-level sustainability orientation and subsequent performance. The hypothesis development draws on stakeholder theory and the literature on mission and revenue drifts, while the empirical analysis is based on two waves of original survey data on
This chapter aims to offer insights into the wider implications for the rule of law, including for the EU constitutional order, of the restrictions of migrants’ and asylum-seeker’ rights that follow from systematic noncompliance with the Common European Asylum System (CEAS) by certain Member States. In other words, has the migration and asylum crisis developed into an EU constitutional crisis? Th
The Advanced Normalizations Tools ecosystem, known as ANTsX, consists of multiple open-source software libraries which house top-performing algorithms used worldwide by scientific and research communities for processing and analyzing biological and medical imaging data. The base software library, ANTs, is built upon, and contributes to, the NIH-sponsored Insight Toolkit. Founded in 2008 with the h
Because biomass is a widely available, renewable resource, its utilisation for the production of energy has great potential for reducing CO2 emissions and thereby preventing global warming. In this mini-review the `state of the art' of several fermentation processes is discussed, starting with the most advanced process of ethanol production. This is followed by methane production, an established p
The road haulage industry is a fundamental part of today’s society. The companies of haulage stand before a challenge, as the environmental and economic sustainability demands are increasing. The automotive industry tries to meet these demands by developing intelligent systems that will decrease the fuel consumption. The two systems, predictive controller and platooning, are two intelligent solut
Huvudsyftet med denna rapport är att förutsäga antalet spelare i nå- gon instans av DICE: s spelplattformar, t.ex. Battlefield 3 för PC, 15 minuter i framtiden. Denna förutsägelse kan användas av företaget vid köp av molnservrar on-demand för att visa dem hur mycket de behöver köpa. Flera olika prognosmodeller undersöks och utvärderas på historisk data från 2011 till 2015. En annan fokuspunkt är hThe main goal of this thesis is to predict the number of players in some instance of DICE’s gaming platforms, e.g. Battlefield 3 for PC, 15 minutes in the future. This prediction may be used by the company when buying on-demand cloud servers to tell them how much they need to buy. Several different prediction models are examined and evaluated on historical data from 2011 to 2015. Another focus poi
In the last couple of years it has become more and more common to use control theory in computing systems, for instance operating systems, web servers and databases. The reason for this is to make these systems more robust and stable. This is of interest because we today are more dependent on computing systems in our everyday life, and therefore put higher demands on them. A lot of focus has been
In this report we study systems governed by the Saint-Venant shallow water equations interacting with boundary conditions including control. We derive closed form formulas for the open-loop behavior. These formulas rely on first, second and third order approximations which are based on a perturbation that we develop. Properties of these solutions are studied and comparisons with existing non-linea
Background The EU’s 20-20-20 targets determine that Finland’s share of energy consumption from renewable energy sources is to be 38 % by 2020, a target that the government intends to reach by expansion of wind power. The government has a beneficial feed-in tariff in place as an incentive for rapid wind power expansion, which has made both domestic and international developers evaluate the business
Resultatet av studien visar att det finns komparativa skillnader på tre olika nivåer. (1) På den nationella nivån framhålls den för arbetstagaren extensiva svenska arbetsrätten och den generösa sjukförsäkringen som potentiella orsaker till att sjukfrånvaron är högre i Sverige än i Danmark. (2) På den organisatoriska nivån konkluderas att de svenska organisationerna har starkare tonvikt på hälsa oc
The study aims to explore the relationship between migration and the quality of education, considering the lowering quality of higher education in Georgia as one of the main ‘push-factors’. The research itself tries to identify the main motivations of why Georgian students migrate. Furthermore, the main gaps and disadvantages of the higher education system of Georgia are investigated. The findings
This study focuses on the human factors associated with elevator use during evacuation in residential buildings. An online survey is conducted to explore seven factors that may influence people’s choice of elevators in China and the United Kingdom, including floor height, waiting time for elevators, crowd density in front of elevators, mobility limitations, instructions, fire location concerning p
This master's thesis explores the potential of integrating floating wind power into Power-to-X (P2X) megaprojects, with a focus on maximizing the output of chemical energy carriers through optimal energy mix strategies. The study evaluates the economic viability and technological efficiency of combining floating wind turbines with photovoltaic panels and battery energy storage systems (BESS) i
Ultrasound optical tomography is a medical imaging modality that combines ultrasound and light to improve the low resolution of optical imaging caused by scattering in tissue. Photons passing through an ultrasound pulse have a probability of being frequency shifted. By filtering out these photons and analysing them, images with optical contrast and ultrasound resolution can be obtained. In this t
This thesis considers solitary standing wave solutions to the Davey-Stewart-son equation, which is a model for surface waves on a body of water in three dimensions. In a special case, the Davey-Stewartson equation is reduced to the well-known non-linear Schrödinger equation with cubic power which is known to have a countable familiy of radial standing waves. One of the aims of this thesis is to in
