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Secondary metabolites from fungi have become a major source of chemical innovation in programs searching for lead molecules with bioactivities, especially over the last 50 years. In this review, we discuss the fundamental considerations in the discovery of molecules for agricultural and medicinal uses. This group of organisms possesses a strong potential for scientific and industrial communities.
We can trace the beginnings of our knowledge of early Upper Paleolithic (Aurignacian) use of fire to the pioneering 1910–1911 excavations at Abri Blanchard undertaken by Louis Didon and Marcel Castanet. At Blanchard, the excavators recognized and described fire structures that correspond in many ways to features excavated more recently in Western and Central Europe. Here, we address the issue of h
The Just-in-Time production system, or lean production system, tries to achieve a continuous flow of production, thereby reducing the inventories of materials, works-in- process and finished products. As a result only minimum levels of inventories exist in the various layers of the supply chain. Under this situation, the major earthquake followed by the tsunami on March 11, 2011 in Eastern Japan,
Knowledge of price formation in fisheries is important in understanding effects of fisheries regulations and the support or resistance to regulations from different stakeholders. This article studies how demand can be traced out using wind speed on a fishing trip. Wind speed is strongly correlated with the quantities of Norwegian lobster (Nephrops) available on the market. Using wind variables as
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Particles beyond the Standard Model (SM) can generically have lifetimes that are long compared to SM particles at the weak scale. When produced at experiments such as the Large Hadron Collider (LHC) at CERN, these long-lived particles (LLPs) can decay far from the interaction vertex of the primary proton–proton collision. Such LLP signatures are distinct from those of promptly decaying particles t
Forests are key components of European multifunctional landscapes and supply numerous forest ecosystem services (FES) fundamental to human well-being. The sustainable provision of FES has the potential to provide responses to major societal challenges, such as climate change, biodiversity loss, or rural development. To identify suitable strategies for the future sustenance of FES, we performed a s
In this paper, the authors present the characterization experiments of a 20 fs vacuum ultraviolet beam from a high harmonic generation source. The beam hits a silicon sample and passes a triple reflection gold polarizer located inside an ultrahigh vacuum chamber. The polarizer's Malus curve was obtained; the total acquisition time for each point of the curve was 30 s. This aims to be the first vac
In light of concerns about adolescent mental health, there is a need to identify and examine potential pathways to wellbeing in their daily lives. Outdoor environments can offer multiple pathways to wellbeing through opportunities for restoration, physical activity and socialising. However, urbanisation and new lifestyles revolving around the home and the internet are changing young people’s acces
A search for the dimuon decay of the Standard Model (SM) Higgs boson is performed using data corresponding to an integrated luminosity of 139 fb−1 collected with the ATLAS detector in Run 2 pp collisions at s=13 TeV at the Large Hadron Collider. The observed (expected) significance over the background-only hypothesis for a Higgs boson with a mass of 125.09 GeV is 2.0σ (1.7σ). The observed upper li
Our global sustainability challenges are complex and require partnerships and collaboration across disciplines and sectors. As such, as a society, we must value interdisciplinary perspectives and work together to address these challenges. In this episode, we discuss the value of interdisciplinary education to address our complex sustainability challenges. We share the experience from our two inter
Vi presenterar skyddsåtgärder som vidtagits som en del av åtgärdsprogrammet ”Projekt Skräntärna” under perioden 2007–2020 i Sveriges största koloni, Stenarna i Björns skärgård, Uppland. En kombination av övervakning, forskning och förvaltningsåtgärder genomfördes enligt en flexibel strategi, där både etablerade och nya tekniker användes. Varje år under häckningssäsongen gjordes fyra besök för att WE PRESENT CONSERVATI ON ACTI ONS during 2007–2020 as part of the national Caspian Tern Hydroprogne caspia species action plan at Stenarna in the Björn archipelago, Uppland, the largest colony in Sweden. We applied a combination of monitoring, research, and management measures conducted within an adaptive approach frame-work, using both established and novel techniques. The implementation of conse
OBJECTIVE: To investigate gastrointestinal infection episodes (GIEs) in relation to the appearance of islet autoantibodies in The Environmental Determinants of Diabetes in the Young (TEDDY) cohort.RESEARCH DESIGN AND METHODS: GIEs on risk of autoantibodies against either insulin (IAA) or GAD (GADA) as the first-appearing autoantibody were assessed in a 10-year follow-up of 7,867 children. Stool vi
Ischemia-reperfusion injury (IRI) plays a crucial role in the development of primary graft dysfunction (PGD) following lung transplantation. A promising novel approach to optimize donor organs before transplantation and reduce the incidence of PGD is mitochondrial transplantation. In this study, we explored the delivery of isolated mitochondria in 4 hour ex vivo lung perfusion (EVLP) before transp
Manual segmentations are considered the gold standard for ground truth in machine learning applications. Such tasks are tedious and time-consuming, albeit necessary to train reliable models. In this work, we present a dataset with expert segmentations of the prostatic zones and urethra for 200 randomly selected patients from the PROSTATEx dataset. Notably, independent duplicate segmentations were
