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PURPOSE: Acquired chemoresistance is a frequent event in small cell lung cancer (SCLC), one of the deadliest human malignancies. Histone deacetylase inhibitors (HDACi) have been shown to synergize with different chemotherapeutic agents including cisplatin. Accordingly, we aimed to investigate the dual targeting of HDAC inhibition and chemotherapy in SCLC.EXPERIMENTAL DESIGN: The efficacy of HDACi

OBJECTIVE: To determine the efficacy and safety of low carbohydrate diets (LCDs) and very low carbohydrate diets (VLCDs) for people with type 2 diabetes. DESIGN: Systematic review and meta-analysis. DATA SOURCES: Searches of CENTRAL, Medline, Embase, CINAHL, CAB, and grey literature sources from inception to 25 August 2020. STUDY SELECTION: Randomized clinical trials evaluating LCDs (<130 g/day or

BACKGROUND: Cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) is the preferred treatment of peritoneal carcinomatosis (PC) of colorectal carcinoma. Patients with positive lymph node status have worse survival after CRS-HIPEC, which is probably due to higher rates of systemic failure. In this study, we analysed the effect of administration and timing of systemic chemot

AIM: We aimed to study the importance of erbB2 status in early stage postmenopausal breast cancer for patients who participated in a trial of five vs. two years of adjuvant tamoxifen.PATIENTS AND METHODS: We analysed the erbB2 status of the tumours from 577 patients participating in the trial, either by a DNA amplification assay (n = 181) or by measurement of the protein level with flow cytometry

Background: Dietary advice remains the cornerstone of prevention and management of type 2 diabetes (T2D). However, understanding the efficacy of dietary interventions is confounded by the challenges inherent in assessing free living diet. Here we profiled dietary metabolites to investigate glycaemic deterioration and cardiometabolic risk in people at risk of or living with T2D. Methods: We analyse

PURPOSE: Adjuvant chemotherapy versus observation and chemotherapy at progression was evaluated in 162 patients in a prospective randomized multicenter study. We also evaluated DNA-measurements as an additional prognostic factor.PATIENTS AND METHODS: Patients received adjuvant carboplatin AUC 7 every 28 days for six courses (n = 81) or no adjuvant treatment (n = 81). Eligibility included surgicall

Socioeconomic status (SES) differences in health are well known. Both material and psychosocial hypotheses regarding these SES differences have been forwarded. Social capital (trust, social participation) may be seen as a contextual and social extension of this debate with access to healthcare as one of the four hypothesized mechanisms between high social capital and health. This thesis investigatSocioeconomic status (SES) differences in health are well known. Both material and psychosocial hypotheses regarding these SES differences have been forwarded. Social capital (trust, social participation) may be seen as a contextual and social extension of this debate with access to healthcare as one of the four hypothesized mechanisms between high social capital and health. This thesis investigat

A major challenge in neuroscience is to resolve the connection between gene functionality, neuronal circuits, and behavior. Most, if not all, neuronal circuits of the adult brain contain a glutamatergic component, the nature of which has been difficult to assess because of the vast cellular abundance of glutamate. In this study, we wanted to determine the role of a restricted subpopulation of glut

Teachers’ perception of organizational communication was assessed with a tailored questionnaire sampling 401 primary and lower secondary school teachers from two municipalities in Sweden (response rate 61 %). Overall, the teachers were satisfied with the workplace communication climate, the communication structure, and collegial communication, while time for communication, was reported deficient.

UNLABELLED: Persistent CB1 cannabinoid receptor activity limits neurotransmitter release at various synapses throughout the brain. However, it is not fully understood how constitutively active CB1 receptors, tonic endocannabinoid signaling, and its regulation by multiple serine hydrolases contribute to the synapse-specific calibration of neurotransmitter release probability. To address this questi

Wildfires are by far the largest contributor to global biomass burning and constitute a large global source of atmospheric traces gases and aerosols. Such emissions have a considerable impact on air quality and constitute a major health hazard. Biomass burning also influences the radiative balance of the atmosphere and is thus not only of societal, but also of significant scientific interest. Ther

ESS linjäraccelerator ska korrigera störningar innan de uppstår. I Lund pågår just nu bygget av europas nya anlägg- ning för forskning med neutronspridning, ESS. Neu- tronspridning är en icke-destuktiv metod för att stu- dera rörelser och strukturer på molekylnivå. Meto- den används som komplement till röntgenstrålning. På liknande sett som man med röntgenstrålning kan se igenom huden på en männisThe purpose of this thesis is to study beam-cavity interactions, with a focus on how to maintain an unperturbed acceleration field in a conducting cavity with a proton beam present. The impact on a cavity acceleration field from different perturbation sources is investigated through computer simulations of a theoreti- cal model based on a resonant circuit. Perturbations from the RF input pulse to

Den föredragna metoden för att syntetisera terapeutiska peptider är idag genom fastfas peptidsyntes (SPPS). SPPS är en process som genererar mycket avfall, där huvudkomponenten i avfallet är de toxiska lösningsmedlen N,N-dimetylformamid (DMF), N-metylpyrrolidon (NMP) och diklormetan (DCM).3 Därför är det önskvärt att söka efter nya och grönare lösningsmedel att använda för SPPS, vilket är vad som The preferred method for synthesising therapeutic peptides today is by Solid-Phase Peptide Synthesis (SPPS). SPPS is a wasteful process, where the main component of the waste is hazardous solvents, i.e., N,N-dimethylformamide (DMF), N-methylpyrrolidone (NMP) or dichloromethane (DCM). 3 It is therefore desirable to search for new and greener solvents to use for SPPS, which is what has been studied

In light of the syllabus concerning film and video game music in the music subject at Swedish compulsory school level, an interview study was conducted. The purpose of the study was to investigate how five active music teachers in compulsory school use music from films and video games in the classroom to teach about music as a meaning-making expressive form. Five semi-structured interviews were co

BACKGROUND: Pancreatic cancer presents as advanced disease in >80% of patients; yet, appropriate ages to consider prevention and early detection strategies are poorly defined. We investigated age-specific associations and attributable risks of pancreatic cancer for established modifiable and non-modifiable risk factors.PATIENTS AND METHODS: We included 167 483 participants from two prospective US

Verksamhetsförutsättningar FÖRUTSÄTTNINGAR INKL. RESURSFÖRDELNING FÖR MEDICINSKA FAKULTETENS VERKSAMHET 2026 Beslutad i Medicinska fakultetsstyrelsen 2025-11-12 Fakultetsstyrelsen BESLUT STYR 2025/2275 Datum 2025-11-12 Del I MEDICINSKA FAKULTETENS VERKSAMHETS- FÖRUTSÄTTNINGAR 2026 Postadress BMC F12, 221 84 LUND Besöksadress Sölvegatan 19, Lund Telefon +46 46 222 72 15 Vxl +46 46 222 00 00 E-post

https://www.intramed.lu.se/sites/intramed.lu.se/files/2025-11/Verksamhetsfo%CC%88ruts%20och%20resursfo%CC%88rd%202026%20TRYCKERIVERSION.pdf - 2026-05-29

Utvärdering av en svensk pilotstudie avseende Mental Health First Aid UTBILDNING I FÖRSTA HJÄLPEN VID PSYKISK OHÄLSA. En effektstudie i två län Bengt Svensson, Sigrid Stjernswärd, Lars Hansson CEPI Maj 2013 2 Innehållsförteckning sid SAMMANFATTNING 3 BAKGRUND 4 Innehållet i utbildningen 4 Utbildning av instruktörer 5 Effekter av programmet 5 Första hjälpen vid psykisk ohälsa i Sverige 6 Utvärderin

https://www.cepi.lu.se/sites/cepi.lu.se/files/rapport_mhfa.pdf - 2026-05-29