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Designing a system for computer aided diagnosis is a complex procedure requiring an understanding of the biology of the disease, insight into hospital workflow and awareness of available technical solutions. This paper aims to show that a valuable system can be designed for diagnosing kidney lesions in children and adolescents from 99m Tc-DMSA scintigraphy images. We present the chain of analysis
The correlation between real-world clinical decisions and adherence to published treatment algorithms for problem bleeding episodes in patients with severe hemophilia and inhibitors and the resultant impact on clinical outcomes were assessed. Nine cases documenting treatment for problem bleeding episodes in patients with severe hemophilia and inhibitors were retrospectively reviewed. Adherence to
Abstract in UndeterminedA one-dimensional model for the sedimentation-compression-dispersion process in the secondary settling tank can be expressed as a nonlinear strongly degenerate parabolic partial differential equation (PDE), which has coefficients with spatial discontinuities. Reliable numerical methods for simulation produce approximate solutions that converge to the physically relevant sol
The anticoagulant vitamin K-dependent protein S (PS) circulates in plasma in two forms, 30% free and 70% being bound to the complement regulatory protein C4b-binding protein (C4BP). The major C4BP isoform consists of 7 alpha-chains and 1 beta-chain (C4BP beta(+)), the chains being linked by disulfide bridges. PS binds to the beta-chain with high affinity. In plasma, PS is in molar excess over C4BP
Vertebral fractures are often painful and lead to reduced quality of life and disability. We compared the efficacy and safety of balloon kyphoplasty to nonsurgical therapy over 24 months in patients with acute painful fractures. Adults with one to three vertebral fractures were randomized within 3 months from onset of pain to undergo kyphoplasty (n = 149) or nonsurgical therapy (n = 151). Quality
The aim of this paper is to make it credible that there are feminist reasons for being a republican about freedom. In focus is Quentin Skinner’s conception of republican, or “neo-Roman”, freedom. Republican theory in history has not excelled in making poverty, gender hierarchy, and racism within the republic into main sources of concern. So can there be a radical republican theory of liberty fit f
Hyperthermia is a frequent complication in patients with acute ischemic stroke. On the other hand, therapeutically induced hypothermia has shown promising potential in animal models of focal cerebral ischemia. This Guideline Document presents the European Stroke Organisation guidelines for the management of temperature in patients with acute ischemic stroke.
Understanding, monitoring and mitigating drought is a very difficult task as a consequence of the intrinsic nature of the phenomenon. In addition, assessing the impact of drought on ecosystems and societies is also a complex task, because the same drought severity may have different consequences in different regions and systems due to the underlying vulnerabilities. New technologies based on geosp
CONTEXT: Prior research suggests that drug abuse (DA) is strongly influenced by both genetic and familial environmental factors. No large-scale adoption study has previously attempted to verify and integrate these findings. OBJECTIVE: To determine how genetic and environmental factors contribute to the risk for DA. DESIGN: Follow-up in 9 public databases (1961-2009) of adopted children and their
Data from four soil profiles studied through pollen and macroscopic charcoal analyses were used to identify specific palynological assemblages associated with a traditional land-use system documented in the Eastern Ligurian Apennines (NW Italy) between the 18th and early 20th century, concerning a cyclical use of grey alder plots for temporary cultivations involving to the use of controlled fire.
Patients with depression and suicidality suffer from low-grade neuroinflammation. Pro-inflammatory cytokines activate indoleamine 2,3-dioxygenase, an initial enzyme of the kynurenine pathway. This pathway produces neuroactive metabolites, including quinolinic- and kynurenic acid, binding to the glutamate N-methyl-d-aspartate-receptor, which is hypothesized to be part of the neural mechanisms under
Objective The Systemic Lupus International Collaborating Clinics (SLICC) group revised and validated the American College of Rheumatology (ACR) systemic lupus erythematosus (SLE) classification criteria in order to improve clinical relevance, meet stringent methodology requirements, and incorporate new knowledge regarding the immunology of SLE. Methods The classification criteria were derived from
The Minnesota Heart Health Program was a community trial of cardiovascular disease prevention methods that was conducted from 1980 to 1990 in three Upper Midwestern communities with three matched comparison communities. A 5- to 6-year intervention program used community-wide and individual health education in an attempt to decrease population risk. A major hypothesis was that the incidence of vali
The aim of this project is to establish a workflow that transforms CT-scanned images of paperboard into a calibrated Representative Volume Element (RVE). A RVE is defined as the smallest volume that accurately captures the macroscopic behaviour of the material. First, CT-scanned images are converted into a finite element model that rep- resents the microstructure of the paperboard. Secondly, a di
Bioacoustic sound event detection (SED) is a critical field for biodiversity monitoring, yet the high cost of annotating data poses significant challenges. This thesis explores the application of active learning strategies to reduce the amount of annotated data required for effective model training. This is done for a segment based SED model, where batch active learning is performed by querying fu
The need for speed in communications systems is increasingly prevalent in modern society, which is one of the driving factors for the evolution of new technologies. At the forefront of this evolution are Multiple-input Multiple-output (MIMO) systems. Through the usage of many antennas at the base station (BS) and user equipment (UE), significantly enhances the potential maximum data transfer rates
Flooding in oil palm plantations in Southeast Asia is a common problem. The oil palm’s habitable range is restricted to lowland equatorial areas, and the high rainfall and degraded landscapes associated with oil palm cultivation leaves oil palm prone to flooding. Flooding diminishes yields in mature palms, increases mortality in young palms, and disrupts operational processes. This reduces the ec
This study investigates interculturality in health communication and deriving power relations. The Bilharzia Storytelling Lab 2022 in Kigali is a health communication program devoting significant attention to the role of culture and representing a new approach to respectful health communication practices. Exploring the Storytelling Lab methodology and its roles provides insights into the innovativ
Credit activity is essential for financial institutions, acting as the primary means banks deploy resources and generate revenue. As a key indicator of financial distress, corporate default has severe repercussions on investors, creditors, regulators, and policymakers. Credit risk embodies the uncertainty banks confront prior to lending, accounting for the partial or complete non-recovery of loan
