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This work introduces a novel analytical method for the detection and study of GAD65 autoantibodies, which have been implicated in the onset of type 1 diabetes. There is a clinical need for a rapid and automated assay for GAD65 autoantibodies. Therefore, this method was designed to exploit the advantages of bead injection (BI) analysis for enzyme-linked immunosorbent assays (ELISA). BI ELISA is a m
Modelling the sedimentation of suspensions with partial differential equations requires constitutive relations (material properties) to be known. Restricted to suspensions obeying Kynch's assumption (ideal suspensions), this paper deals with the inverse problem, which is to estimate the batch-settling flux function from experimental data. A new batch-settling test is suggested, from which it is th
Polychlorinated biphenyls (PCBs) in water were extracted with a rebuilt extraction unit using 47 mm C18 solid-phase extraction (SPE) disks. Three types of disks (SPEC, ENVI and Empore) were investigated for the extraction of seven PCBs from 1 l reagent water spiked at two concentration levels (20 and 1000 ng/l). The Empore disks produced the best analyte recoveries (91–107% with R.S.D. of 1–8%) at
A monogenic inheritance, mainly seen as a dominant pattern, accounts for 5 - 10% of all cancer cases. The increased knowledge and identification of high-risk genes have led to a need for specialized cancer family clinic was the expression used by Eeles and Murday. The Oncogenetic Clinic at the University Hospital in Lund was started in 1993 and the authors' 10-year experience is summarized in this
A novel process for the production of biodegradable lubricant-based stocks from epoxidized vegetable oil with a lower pour point via cationic ion-exchange resins as catalysts was developed. This involves two steps, first, ring-opening reactions by alcoholysis followed by esterification of the resultant hydroxy group in the first step. The ring-opening reaction of epoxidized soybean oil with differ
Protein C (PC), a 62 kDa multi-modular zymogen, is activated to an anticoagulant serine protease (activated PC or APC) by thrombin bound to thrombomodulin on the surface of endothelial cells. PC/APC interacts with many proteins and the characterisation of these interactions is not trivial. However, molecular modelling methods help to study these complex biological processes and provide basis for r
Effects of ultraviolet (UV)-B radiation and acidification on pelagic carbon flux in a humic lake (dissolved organic carbon [DOC] similar to15 mg C L-1) were studied in a mesocosm experiment during the summer of 2000. Triplicate tanks (107 liters volume, 1 m high) were exposed to natural solar radiation, a daily extra dose of UV-B radiation, or kept dark. One set of tanks was submitted to a decreas
Two methods for visual evaluation of image quality of clinical radiographs have been compared. In visual grading analysis (VGA) specified anatomical structures in an image are visually compared with the same structures in a reference image, and in a free-response forced error (FFE) experiment - an extension of conventional ROC (receiver operating characteristics) analysis - the objective is to cor
Ultrafast accelerator-based sources combined with synchronized femtosecond lasers are currently being developed. The method described here is intended as a jitter monitor at such facilities. We report on the possibility of extracting a time-offset signal between two different synchronized ultrashort light pulses. The method is based on sum-frequency generation in a nonlinear crystal. Aiming at ext
This paper analyzes if patients’ demand for Direct-to-Consumer Telemedicine (DCT) providers is affected by a change in patient fees. The paper utilizes a natural experiment when the patient fee increased for patients in Region Stockholm using one DCT provider but remained unchanged for other DCT providers. By using DCT visits per month for all other regions as control, the effect on the demand for
The combined global emergence of a sustainable development discourse and Swedish policies requiring municipalities to rapidly build new housing have led Lund to develop Brunnshög. This pioneering megaproject balances urban expansion with high sustainability ambitions. Through the lens of urban political ecology, this thesis aims at analysing Brunnshög’s dominant sustainability narrative as told by
The ability to hear is essential for receiving auditory signals, which serve as warnings and alerts in many situations, including fire evacuation. However, people with hearing impairments may miss out such signals and can be exposed to dangerous situations. This is particularly relevant in scenarios where audible alarms are the primary form of alert, such as in fire scenarios, natural hazards, or
ADHD is a common neurodevelopmental disorder that is defined by a pattern of hyperactivity and/or inattention that negatively affects an individual’s ability to function in everyday life. There are a multitude of challenges in correctly diagnosing ADHD. Symptoms are primarily behavior based and there are not any good biomarkers that can be used to help clinicians to diagnose the disorder correctly
This thesis is inspired by the lack of academic discourse on human rights aspects of human space settlement. It builds on the ever-growing literature on colonizing Mars and the ongoing public debate on the benefits versus disadvantages thereof. Taking on a critical approach, this thesis opens up a conversation on power, universalism, and legitimacy within space exploration, questioning both the on
A prototype of a novel 10B-based neutron detector called the Multi-Grid detector has been constructed, tested and commissioned for the European Spallation Source (ESS). The detector is constructed after the specifications set by the CSPEC instrument at ESS and is therefore called the CSPEC Multi-Grid detector. The detector uses multiple layers of solid coating containing 10B4C on the edges of a vo
The median age for Swedish earth embankment dams is about 60 years. Due to its longevity, one of the major concerns is the internal erosion causing increased seepage through the dam, which ultimately may increases the risk for dam failure. To meet this challenge, there is a need for improved monitoring methods. This in turn requires sensors to be installed inside the earth embankment dams in order
The behaviour and fate of stem cells is governed by the material properties of their surrounding microenvironment. Hence emulating the extracellular matrix poses as an attractive target for tissue engineering endeavours to create a stem cell substrate. Currently, the knowledge of the material properties is mostly limited to the macroscopic level which considerably limits the understanding of tissu
