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In the present study, the involvement of cytochrome P450 enzyme( s) in the primary metabolism of laquinimod, a new orally active immunomodulator, has been investigated in human liver microsomes. Hydroxylated and dealkylated metabolites were formed. The metabolite formation exhibited single enzyme Michaelis-Menten kinetics with apparent K-M in the range of 0.09 to 1.9 mM and V-max from 22 to 120 pm

During amino acid starvation the Escherichia coli stringent response factor RelA recognizes deacylated tRNA in the ribosomal A-site. This interaction activates RelA-mediated synthesis of alarmone nucleotides pppGpp and ppGpp, collectively referred to as (p)ppGpp. These two alarmones are synthesized by addition of a pyrophosphate moiety to the 3 position of the abundant cellular nucleotide GTP and

Whistle-blowing can serve as a powerful mechanism helping policy-makers and other stakeholders recognize ethical misconduct and other types of wrongdoing in autonomous public agencies. This mechanism is of particular importance in major public sector reforms, such as agency mergers, when it may be difficult to secure continuity in the quality of organizational processes. Yet, we know little of wha

“The customer is always right”: A qualitative study of how service-providing companies deal with public customer complaints filed on social network sites. Customers have always voiced their complaints, but with the emergence of the Internet and the rise of social media, the medium they used to do so has changed. While beforehand, customers contacted companies through letters or phone calls, nowada

Purpose To examine if Chinese acquirers create short-term shareholder wealth through cross-border acquisitions, measured by fluctuations of the stock price of the acquiring firm. Additionally, to investigate if industrial, institutional and cultural independent variables affect the cumulative abnormal returns. Methodology The study is quantitative with a deductive approach and based on the tradit

Today, as our cities are becoming increasingly dense - the role of internal spaces are rising as ever-more important in defining urbanity. And in a moment in which our private lives have become exposed and controlled in almost every aspect, the interior has become the eminent space of refuge, providing anonymity and freedom. In Is the New Out offers a radical reexamination of the interior as the l

This study aims to investigate consumers’ perceptions of luxury fashion brands and whether these perceptions differ with and without the context of luxury rental platforms. A qualitative methodology was adapted, using semi-structured interviews and an abductive research approach. In order to investigate consumer perception of luxury brands in the context of rental platforms, the study applied con

Research Question: How do Swedish coworking firms internationalise, and what are the Key Success Factors allowing for a successful internationalisation? Purpose: This study investigates what drives international expansion for Swedish coworking firms. It also sees why these internationalisation projects were or were not successful. By identifying the key factors behind the projects, the study aims

Since the early 1980’s and up until today many organizations have realized the importance of paying more and more attention to the effective strategic planning of the information systems resources. There are several reasons for this that where recognized by Pyburn (1983), one was the high speed of technological progress both in regards to IT and Telecoms facilities. Another key factor, which is ve

MILJÖVETENSKAP Preliminärt schema 170609 Kurs: MVEN015, Klimatförändringen, vetenskap och samhälle Kursansvarig: Niklas Vareman Lärare: Giuliana Zanchi, Maj-Lena Linderson, Johannes Stripple, Niklas Vareman, Johanna Alkan-Olsson, Dan Hammarlund, David Harnesk Lokaler: Retina (D227) i Biologihuset, Sölvegatan 35, se karta Se karta http://www.biologi.lu.se/sites/biologi.lu.se/files/biologiv2a4.pdf L

https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/schema_mv15_ht17_v.1.pdf - 2026-07-18

Read about Sophias thoughts on being an international student at Lund.