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Background: Noise is typically conceived of as being detrimental to cognitive performance. However, given the mechanism of stochastic resonance, a certain amount of noise can benefit performance. We investigate cognitive performance in noisy environments in relation to a neurocomputational model of attention deficit hyperactivity disorder (ADHD) and dopamine. The Moderate Brain Arousal model (MBA;
Popular Abstract in English Proteins are a class of biological macromolecules that perform countless fundamental and diverse functions in living organisms. Chemically speaking, they are polymers built out of monomeric units called amino acids. All biological proteins are constructed out of 20 different amino-acid types. To form protein molecules, amino acids are linked together in a linear chain lThe minimum free energy state of a protein (the native state) is encoded by its amino-acid sequence. Due to the many torsional degrees of freedom (DOF) available to a polypeptide chain, a vast number of conformations is possible. Therefore, to predict the native state of a protein directly from sequence, a computer algorithm must evaluate a large number of possible conformations using accurate sco
Circadian clocks were, until recently, seen as a consequence of rhythmic transcription of clock components, directed by transcriptional/translational feedback loops (TTFLs). Oscillations of protein modification were then discovered in cyanobacteria [1, 2]. Canonical posttranslational signaling processes have known importance for clocks across taxa [3, 4, 5, 6, 7, 8, 9, 10, 11]. More recently, evid
Background: Synaptic degeneration is a central pathogenic event in Alzheimer's disease that occurs early during the course of disease and correlates with cognitive symptoms. The pre-synaptic vesicle protein synaptotagmin-1 appears to be essential for the maintenance of an intact synaptic transmission and cognitive function. Synaptotagmin-1 in cerebrospinal fluid is a candidate Alzheimer biomarker
Will developing countries benefit economically from strengthening their protection of intellectual property? They have been repeatedly urged to do so by developed nations. But so far there is little empirical experience of either quite successful or failed examples. What we could hear from the media seems that the international protection of IPRs is getting stricter and more codified, while the si
There has been considerable scepticism in Europe over the reliability of Russia as a secure source of energy for the EU. Despite Russia and EU being economically interdependent with regard to energy and other trade, there is still concern over potential supply disruptions. What can be gathered from media and scholarly sources is that Russia is potentially an unreliable supplier yet it is currently
The calcium-releasing second messenger inositol 1,4,5-trisphosphate is involved in the regulation of stomatal aperture by ABA. In other signalling pathways, inositol 1,4,5-trisphosphate is generated by the action of phospholipase C. We have studied the importance of phospholipase C in guard cell ABA-signalling pathways. Immunolocalisation of a calcium-activated phospholipase C confirmed the presen
The biogenesis of transfer RNA is a process that requires many different factors. In this study, we describe a genetic screen aimed to identify gene products participating in this process. By screening for mutations lethal in combination with a sup61-T47:2C allele, coding for a mutant form of, the nonessential TAN1 gene was identified. We show that the TAN1 gene product is required for formation o
BackgroundIn Prostate-specific membrane antigen (PSMA) positron emission tomography with computed tomography (PET-CT), there is significant renal uptake. The standard in renal cortical functional imaging is scintigraphy with technetium-99m labeled dimercaptosuccinic acid (DMSA). Using [68Ga]Ga-PSMA-11 PET for renal imaging has been suggested, but using [18F]PSMA-1007 has not been explored. The aim
Background: The power and influence of the hidden curriculum - culturally situated norms and values - onlearning opportunities is a growing concern in medical education. However, while medical schools producediversity and equal treatment policies, efforts towards surfacing and addressing equal opportunities in theclinical learning environment trail behind.Summary of Work: To better understand how
Syndecan-2 is a heparan sulfate proteoglycan that has a cell adhesion regulatory domain contained within its extracellular core protein. Cell adhesion to the syndecan-2 extracellular domain (S2ED) is β1 integrin dependent; however, syndecan-2 is not an integrin ligand. Here the protein tyrosine phosphatase receptor CD148 is shown to be a key intermediary in cell adhesion to S2ED, with downstream β
Calculus of variations is a branch of mathematics that was developed in the 18th century to solve problems of determining optimal trajectories, shapes and structures subject to constraints. It deals with the minimization of a certain type of integral functional. In the early days of the theory, the smoothness of the functions involved was assumed but, during the following centuries, advances in an
MILJÖVETENSKAP Preliminärt schema 170509 Kurs: MVEN03 - Miljövetenskap: Analys och metodik, 15 hp HT 2017 Kursansvarig: Nina Reistad NR nina.reistad@fysik.lth.se Lärare: Sofia Hydbom SH sofia.hydbom@biol.lu.se Estelle Larsson EL estelle.larsson@med.lu.se Per Erik Isberg PEI per-erik.isberg@stat.lu.se Pål Axel Olsson PAO pal_axel.olsson@biol.lu.se Martijn van Praagh MVP martijn.van_praagh@mv.lu.se
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/mven03_schemamall_mv_ht17_v1.pdf - 2026-07-13
