Search results

B-lymphoblastic leukemia/lymphoma (B-ALL) is the most common pediatric malignancy and the most commonly diagnosed adult lymphoblastic leukemia. Recent advances have broadened the spectrum of B-ALL, with DUX4 gene fusions implicated in a subclass occurring in adolescents and young adults and harboring a favorable prognosis. DUX4 fusions have been challenging to identify. We aimed to determine wheth

Natural products are compounds that exist naturally in living organisms, e.g.,plants, animal and fungi. These compounds are likely biologically active and canbe used as pharmaceuticals for various diseases. Evolution has made it possible forliving organisms to produce these natural products as a defence mechanism againstvarious threats. In most cases, the organism only produces a small amount of tThis thesis describes our efforts towards the total synthesis of natural products and the development of a newmethodology to afford a synthetically important scaffold.Chapter 2 outlines our efforts towards the total synthesis of a marine natural product, perophoramidine as wellas our completed synthesis of dehaloperophoramidine. The focus of the studies was to develop an efficient andconcise strat

Multi-component reflection methods have gained acceptance for near surface mapping during recent years. Two case studies from Denmark employing shear wave reflection at different survey scales are presented. The first case study is a small site scale investigation to image the near surface lithology of a contaminated site. Here the S-wave reflection mapping was employed to update the Conceptual Si

Cyclin-dependent kinase 1 (Cdk1) is an archetypical kinase and a central regulator that drives cells through G2 phase and mitosis. Knockouts of Cdk2, Cdk3, Cdk4, or Cdk6 have resulted in viable mice, but the in vivo functions of Cdk1 have not been fully explored in mammals. Here we have generated a conditional-knockout mouse model to study the functions of Cdk1 in vivo. Ablation of Cdk1 leads to a

Background: Previous studies have proposed growth differentiation factor-15 (GDF-15) as a predictor of adverse cardiovascular outcomes and mortality. The present study aimed to determine if such associations remain after accounting for death as a competing risk, and if GDF-15 provides superior prediction performance than other biomarkers. Methods: Plasma GDF-15 levels and cardiovascular risk facto

11 maj 2026 10:00 till 11:00 | The CRC seminars bring up current medical research by researchers at Clinical Research Centre (CRC), Lund University and invited guests. SpeakerDr. Vincenzo CoppolaAssociate ProfessorDepartment of Cancer Biology and Genetics Wexner Medical CenterOhio State University - Comprensive Cancer CenterColumbus, Ohio, USTitleThe uniqueness of the CTLH complex at the crossroad

https://www.medicin.lu.se/evenemang/crc-seminar-dr-vincenzo-coppola - 2026-07-04

Recent work from several laboratories has demonstrated that proteolytic mechanisms significantly contribute to the molecular interplay between Streptococcus pyogenes, an important human pathogen, and its host. Here we describe the identification, purification and characterization of a novel extracellular cysteine proteinase produced by S.pyogenes. This enzyme, designated IdeS for Immunoglobulin G-

The aim of this essay has been to study the work of personal agents in Kristianstad. Personal agents was initiated by National Government with the purpose to recognize the needs of mentally disabled, and through a function as coordinaters give a better support to these clients. The main questions in this study are focused on the personal agents experience of their work, and how clients and their i

Popular Abstract in English Colors have always been part of human life and culture. Today natural pigments have been substituted by synthetic dyes that usually end up threatening nature itself by polluting the environment. To what extent can we use chemistry and biology to minimize the environmental impact of the textile industry? During the dyeing process a certain amount of dye, 2 to 50 percent,Treatment of textile wastewater is challenging because the water contains toxic compounds that have low biodegradability. Dyes, detergents, surfactants, biocides and more are used to improve the textile process and to make the clothes resistant to physical, chemical and biological agents. New technologies have been developed in the last decades and in particular Advanced Oxidation Processes (AOPs)

26 februari 2026 17:15 till 19:00 | Övrigt Are you a PhD student or postdoc interested in exploring new opportunities beyond academia? Join our After Science Network meet-up in February and learn how your research can lead to real-world impact through innovation and entrepreneurship. LU Innovation, together with Lund's Doctoral Student Union and the Doctoral Guild of the faculty of Engineering, in

https://www.medicin.lu.se/evenemang/after-science-network-1 - 2026-07-04

https://www.nateko.lu.se/sites/nateko.lu.se/files/2021-02/ngen02_course_evaluation_2019.pdf - 2026-07-04

Fuzzy Borders and Postcolonial Forgotten Zones: The Case of Indo-Bangladeshi Enclaves Fuzzy Borders and Postcolonial Forgotten Zones: The Case of Indo-Bangladeshi Enclaves AMRITA GHOSH | SASNET PUBLICATIONS REPORT 2021:2 SASNET | LUND UNIVERSITY Author: Amrita Ghosh Information about Author: Amrita Ghosh has a Ph.D in literature and Partition Studies from Drew University, USA, and a postdoc from L

https://www.sasnet.lu.se/sites/sasnet.lu.se/files/2021-02/SASNET_Rapport_Ghosh_2021-02.pdf - 2026-07-04

Popular Abstract in English Life on earth has evolved countless forms, beautiful shapes and colors as well as astonishingly complex systems. Remarkably, all living creatures consist of cells, which themselves are build from the same basic set of molecules, most importantly nucleic acids (RNA and DNA), lipids and proteins. The latter are large macromolecules that fulfill a vast number of tasks; theThe three-dimensional structure of protein is encoded in its amino acid sequence. Modern structure prediction algorithms make it possible to predict the structure of small proteins using sequence information alone. We used the Fold-and-Dock algorithm, which is part of the Rosetta macromolecular modeling suite, for de novo structure prediction of coiled-coil proteins. Members of this protein family

Popular Abstract in English Since the onset of the 20th century, human society has been using non-renewable resources, mainly oil, for the production of fuels and chemicals that are now an integral part of our everyday life. In the last few decades however, concerns regarding environmental effects, geopolitical issues and the eventual depletion of oil have led to us re-evaluating our dependency onConcerns regarding environmental issues such as greenhouse gas emissions and climate change have led to a shift within the research community and chemical and energy industry sectors for finding sustainable routes for producing fuels and chemicals from renewable resources, thereby minimizing our dependence on petroleum. The C3-chemical 3-hydroxypropionic acid has been identifed as a top candidate

OBJECTIVE: Mapping coreceptor epitopes used by the prototypic R5 and X4 strains, HIV-1BaL and HIV-1IIIB, in comparison with epitopes involved in the activation and signaling induced by the natural ligands, RANTES and SDF-1beta. DESIGN: Receptor hybrids between CCR5 and CXCR4 were constructed. METHODS: Using single-overlap and extension PCR, increasing portions of CCR5 were replaced with correspond

Currently I am studying the realization of two large-scale experimental natural science facilities: The European Spallation Source (ESS) and MAX IV (a synchrotron facility). They are examples of New Big Science (NBS) – facilities where substantial amounts of resources and hopes are tied to making future scientific discoveries. Both facilities will host more than 20 different instruments, catering Feminist technoscience studies (FTS) comprise a major strand of STS. Constituted by a diverse and heterogeneous set of projects and publications, these studies make politicised, impassioned contributions to contemporary critical thought about science, technology and medicine. They are also driven by a powerful desire for justice (see Reardon et al in Catalyst Vol 1 No 1). Building on century-old t

GAD65 autoantibodies (GAD65Ab) are highly prevalent in type 1 diabetes, but their functional role in the pathogenesis of the disease and their relationship to T-cell reactivity to GAD65 is still unclear. We tested the hypothesis that GAD65Ab modulate presentation of GAD65 to T-cells. T-cell hybridoma T33.1, which recognizes the GAD65 274-286 epitope in the context of HLA-DRB1*0401, was incubated w