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Antigenic peptide delivery to antigen-presenting cells using a CD40-coiled coil affinity-based platform

Delivery of antigenic peptides to antigen presenting cells (APCs) such as dendritic cells (DCs) using monoclonal antibodies (mAbs) is an attractive approach to evoke antigen-specific T cell activation and improve drug efficacy. Peptide linkage to mAbs has previously been achieved through genetic fusion, chemical conjugation, nano-engineered platforms and high affinity peptides. In this study, we h

Towards alkali-stable polymers and hydroxide exchange membranes functionalized with alicyclic quaternary ammonium cations

In the current work, cationic polymers functionalized with N-alicyclic quaternary ammonium (QA) cations were synthesized and characterized as potential hydroxide exchange membranes (HEMs) for application in fuel cells. Three different polymers, namely poly(arylene ether sulfone), spiro-ionene and poly(arylene alkylene), were explored as polymer backbones for the HEMs. Various mono- and spirocyclic

IgG Binds Escherichia coli Serine Protease EspP and Protects Mice From E. coli O157:H7 Infection

Shiga toxin-producing Escherichia coli O157:H7 is a virulent strain causing severe gastrointestinal infection, hemolytic uremic syndrome and death. To date there are no specific therapies to reduce progression of disease. Here we investigated the effect of pooled immunoglobulins (IgG) on the course of disease in a mouse model of intragastric E. coli O157:H7 inoculation. Intraperitoneal administrat

Development and validation of a machine learning-based model to predict isolated post-challenge hyperglycemia in middle-aged and elder adults : Analysis from a multicentric study

Introduction: Due to the high cost and complexity, the oral glucose tolerance test is not adopted as the screening method for identifying diabetes patients, which leads to the misdiagnosis of patients with isolated post-challenge hyperglycemia (IPH), that is., patients with normal fasting plasma glucose (<7.0 mmoL/L) and abnormal 2-h postprandial blood glucose (≥11.1 mmoL/L). We aimed to develop a

A Simulation Study Quantifying the Effects of Drive Cycle Characteristics on the Performance of a Pneumatic Hybrid Bus

In the study presented in this paper, the effect of different vehicle driving cycles on the pneumatic hybrid has been investigated. The pneumatic hybrid powertrain has been modeled in UT-Power and validated against experimental data. The GT-Power engine model has been linked with a MATLAB/simulink vehicle model. The engine in question is a single-cylinder Scania D12 diesel engine, which has been c

Analysis of tracer molecules from organic aerosols - Application of liquid phase microextraction to aerosol analysis

Popular Abstract in English Airborne particulate matter is well known because of its adverse impacts on human health and its role in climate processes. In order to understand completely the role of aerosols in atmosphere, their chemical composition is of basic importance. Chemical analysis of aerosols involves broadly two steps, extraction step and detection/quantification of chemical constituentsAirborne particulate matter is well known because of its adverse impacts on human health and its role in climate processes. In order to understand completely the role of aerosols in atmosphere, their chemical composition is of basic importance. Chemical analysis of aerosols involves broadly two steps, extraction step and detection/quantification of chemical constituents. Generally aerosols are ext

Two-Stage Conversion of Land and Marine Biomass for Biogas and Biohydrogen Production

The replacement of fossil fuels by renewable fuels such as biogas and biohydrogen will require efficient and economically competitive process technologies together with new kinds of biomass. A two-stage system for biogas production has several advantages over the widely used one-stage continuous stirred tank reactor (CSTR). However, it has not yet been widely implemented on a large scale. Biohydro

Mode of Coreceptor Use by R5 HIV Type 1 Correlates with Disease Stage: A Study of Paired Plasma and Cerebrospinal Fluid Isolates.

Abstract Through the use of chimeric CXCR4/CCR5 receptors we have previously shown that CCR5-tropic (R5) HIV-1 isolates acquire a more flexible receptor use over time, and that this links to a reduced viral susceptibility to inhibition by the CCR5 ligand RANTES. These findings may have relevance with regards to the efficacy of antiretroviral compounds that target CCR5/virus interactions. Compartme

Practical Aspects of Reduced Complexity LDPC Decoding using Forced Convergence

This thesis is an extension to the previous work done at Department of EIT in investigating the complexity reduction of LDPC decoding using the stochastic approximation method to improve the energy efficiency of energy-limited applica- tions, such as in mobile phones. The research carried out in this thesis investigates the complexity and conver- gence results of adaptive performance control algorit

Cultured Mast Cells from Patients with Asthma and Controls Respond with Similar Sensitivity to Recombinant Der P2-Induced, IgE-Mediated Activation

The function of cultured mast cells may depend on genetic or environmental influence on the stem cell donor. This study investigates whether asthma or atopy in the donor influenced the growth and sensitivity of mast cells cultured from patients with asthma and healthy controls under identical conditions. Mast cells were cultured from peripheral blood from twelve patients with an objectively confir

Schema mven03 ht15 v11

MVEN03 Scema hösten 2015 Centrum för miljö- och klimatforskning, CEC www.miljovetenskap.lu.se 2015-08-24 Nina Reistad MVEN03 - Miljövetenskap: Analys och metodik, 15 hp HT 2015 Preliminärt schema Kursansvarig: Nina Reistad NR nina.reistad@fysik.lth.se Lärare: Sofia Hydbom SH sofia.hydbom@biol.lu.se Estelle Larsson EL estelle.larsson@trelleborg.se Per Erik Isberg PEI per-erik.isberg@stat.lu.se Pål

https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/schema_mven03_ht15_v11.pdf - 2026-06-05

Socioeconomic inequalities in the kidney transplantation process : A registry-based study in Sweden

Socioeconomic Inequalities in the KidneyTransplantation Process: A Registry-BasedStudy in SwedenYe Zhang, MSc,1Ulf-G. Gerdtham, PhD,1,2,3Helena Rydell, MD,4,5,6and Johan Jarl, PhD1Background.Few studies have examined the association between individual-level socioeconomic status and access to kidney transplantation. This study aims to investigate the association between predialysis income and educaBackground. Few studies have examined the association between individual-level socioeconomic status and access to kidney transplantation. This study aims to investigate the association between predialysis income and education, and access to (i) the kidney waitlist (first listing), and (ii) kidney transplantation conditional on waitlist placement. Adjustment will be made for a number of medical and

School choice in urban China: educational desires and life-packages between the state and the market

Questions around school choice have attracted growing attention among educational scholars worldwide, and there is by now a burgeoning body of literature that links school choice to (i) the marketization and commercialization in education, (ii) new modes of governance in education, and (iii) individualized patterns of life-planning among families who see themselves increasingly exposed to global c

Striking a blow for physical meetings!

Striking a blow for physical meetings! Hoppa till huvudinnehåll Vi använder cookies och andra spårningsteknologier för att förbättra användarupplevelsen på vår webbplats, för att visa dig personligt innehåll och riktade annonser och för att analysera vår webbplatstrafik. Läs mer om cookies. Absolut nödvändiga cookies Dessa cookies är nödvändiga för att webbplatsen ska fungera och kan inte stängas

https://www.lth.se/article/striking-a-blow-for-physical-meetings/ - 2026-06-05

All solid state single-shot Dispersion scan (D-Scan) for ultrashort laser pulses

Ultrashort laser pulses play an important role in many applications in science and technology, from attosecond science to time resolved spectroscopy and material processing. For applications of ultrashort laser pulses, it requires a complete characterization of the electric field of the pulse, which includes both phase and amplitude of the electric field. The characterization of ultrashort laser pThe human eye can clearly observe movements as fast as around 0.1 seconds long, but how can we observe the movement that is way too fast for the human eye? For example, you can barely read any labels from a really fast moving formula 1 car. However, if we use a camera which can act faster than the human eye, we can capture the images of the moving object. When a camera takes a picture, it records

AI Implementation in Medicine from Healthcare Professionals’ Perspective: an interview-based explorative study

Artificial intelligence (AI) is rapidly transforming healthcare, yet its successful integration depends heavily on the acceptance and understanding of this technology by medical professionals. Our qualitative exploratory study, using semi-structured interviews with eight medical professionals in Sweden and Denmark, charts their perceptions of AI's implementation in medicine. The primary goal o