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Background: Inherited BRCA1 and BRCA2 (BRCA1/2) mutations confer elevated breast cancer risk. Knowledge of factors that can improve breast cancer risk assessment in BRCA1/2 mutation carriers may improve personalized cancer prevention strategies. Methods: A cohort of 5,546 BRCA1 and 2,865 BRCA2 mutation carriers was used to evaluate risk of breast cancer associated with BARD1 Cys557Ser. In a second
The purpose of this thesis is to examine the level of conict in the media between the government and the opposition at dierent time periods, and specically regarding EU policies. Opposition towards policy is a crucial ingredient in democratic systems of government that do not only allow the people to send dierent personalities to represent them in government, but rather dierent policy agendas that
BACKGROUND: The transport of large proteins across the glomerular capillary wall (GCW) may increase several fold in glomerular diseases. The occurrence of IgM in urine is a consequence of the presence of large defects or shunts in the GCW, whereas albuminuria is probably a result of an altered charge- and size-selectivity of the GCW. In order to examine whether patho-morphological differences infl
Antigen presentation to T cells by MHC molecules is essential for adaptive immune responses. To determine the exact position of a gene affecting expression of MHC molecules, we finely mapped a previously defined rat quantitative trait locus regulating MHC class II on microglia in an advanced intercross line. We identified a small interval including the gene MHC class II transactivator (Mhc2ta) and
Abstract is not available
This thesis focuses on cold ironing for vessels while berthed at port, with the port of Copenhagen as main case study. With the use of this technique, which is considered by the International Marine Organization (IMO) as a measure to reduce air pollution and noise deriving from shipping activities in ports and coastal areas, vessels are able to shut down their auxiliary engines in order to generat
Purpose The purpose of this thesis is to contribute with knowledge on consumer identity in a social media setting and how companies can utilize this behaviour for effective marketing. Method The thesis adopts a constructivist perspective on how we interpret our interviewees, the reality and our own research role. The interviews have been inspired by both ethnographic and a phenomenological appro
Background: Physical activity (PA) increases bone mass, especially in late prepuberty and early puberty, but it remains unclear if and how PA affects both bone formation and bone resorption. Materials and Methods: We included 191 boys and 158 girls aged 7.7 ± 0.6 (mean ± SD) in a population-based PA intervention study. The intervention group (123 boys and 94 girls) received daily physical educatio
Tumor-associated macrophages (TAMs) have emerged as key players in tumor immunology but demonstrate a continuum of functional states being either tumor suppressive or promoting. Moreover, chemotherapeutic agents have been shown to alter the tumor microenvironment. Perioperative chemotherapy is a standard treatment option for resectable esophageal and gastric (EG) adenocarcinoma. The aim of this st
Background and aims: Extracellular matrix (ECM) remodeling is one of the key components in the formation of vulnerable atherosclerotic plaques and cardiovascular events. We recently showed that the full-length ECM-proteoglycan osteoglycin was associated with plaque vulnerability and future cardiovascular events. In the present study, we aimed to investigate the association of cleaved osteoglycin w
The way in which we produce and consume energy has profound implications for our societies. How we configure our energy systems determines not only our chances of successfully dealing with climate change but also, how benefits and burdens of these systems are distributed. In this paper, we set out to map the literature on conflicts related to the energy system in Sweden using a framework of energy
Amplification of the MYCN oncogene is found in ~20% of neuroblastoma (NB) cases and correlates with high-risk disease and poor prognosis. Despite the plethora of studies describing the role of MYCN in NB, the exact molecular mechanisms underlying MYCN’s contribution to high-risk disease are not completely understood. Herein, we implemented an integrative approach combining publicly available RNA-S
