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Glucagon receptor (Gcgr) signaling maintains hepatic glucose production during the fasting state; however, the importance of the Gcgr for lipid metabolism is unclear. We show here that fasted Gcgr-/- mice exhibit a significant increase in hepatic triglyceride secretion and fasting increases fatty acid oxidation (FAO) in wild-type (WT) but not in Gcgr-/- mice. Moreover fasting upregulated the expre

Följderna av narkotikamissbruk kostar samhället stora summor pengar varje år. Att beräkna den exakta storleken på dessa summor är omöjligt, eftersom stora delar av den narkotikarelaterade verksamheten är olaglig. De kostnadsberäkningar man kan göra blir ungefärliga uppskattningar. Ändå är det viktigt att försöka, eftersom den kunskap man har om kostnaderna för narkotikamissbrukets konsekvenser utg

Available HIV treatments are unsatisfactory since they don’t clear the infection and result in expensive and life‐long treatment on an every‐day basis without clear evidence of the long‐term consequences and side effects of this. Our research is highly translational and combines clinical, experimental and bioinformatics research in various systems virology approaches to uncover nocel key virus-hos

Background/Aim: Several studies have described that oxytocin exerts stimulatory or inhibitory effects on gut functions. Recently, mRNA for oxytocin and its receptor was found throughout the entire human gastrointestinal (GI) tract. The aim of this study was to examine the cellular localization and distribution of the corresponding proteins. Material and methods: Full-thickness biopsies from 24 pat

Several previous authors have argued that Finnish lacks a true passive construction, and relabel the form ''indefinite,''''impersonal'' or ''suppressive'.' In this paper, we first devise a set of criteria for passives cross-linguistically; we then present syntactic and morphological evidence to show that the Finnish construction displays all the key features we would expect from a passive.

Purpose: This research explores how status is manifested within the foodie culture. More specifically, we explored how foodies claim status and express inconspicuous meanings through their food consumption practices. Methodology: A hermeneutical epistemology approach was pursued, with the use of Interpretivism to generate insights into the foodie lived experience. A constructionist ontological pe

This project aims to develop incretin therapy as a glucose-reducing strategy in type 2 diabetes (T2D). Its particular focus is to understand the mechanisms of incretin therapy and to optimize its clinical positioning. This mission is achieved by an interdisciplinary approach with complementary studies in subjects with T2D, healthy volunteers and experimental animals.