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Objective: Women with a prior history of polycystic ovary syndrome (PCOS) have an increased risk of endometrial cancer (EC). Aim: To investigate whether the endometrium of women with PCOS possesses gene expression changes similar to those found in EC. Design and Methods: Patients with EC, PCOS and control women unaffected by either PCOS or EC were recruited into a cross-sectional study at the Nott

A Swedish pedigree with an autosomal dominant inheritance of idiopathic scoliosis was initially studied by genetic linkage analysis, prioritising genomic regions for further analysis. This revealed a locus on chromosome 1 with a putative risk haplotype shared by all affected individuals. Two affected individuals were subsequently exome-sequenced, identifying a rare, non-synonymous variant in the C

There is a great need to identify new and better prognostic and predictive biomarkers to stratify prostate cancer patients for optimal treatment. The aims of this study were to characterize the expression profile of pre-B cell leukemia homeobox (PBX) transcription factors in prostate cancer with an emphasis on investigating whether PBX3 harbours any prognostic value. The expression profile of PBX3

We show that tree-like resolution is not automatable in time no(log n) unless ETH is false. This implies that, under ETH, the algorithm given by Beame and Pitassi (FOCS 1996) that automates tree-like resolution in time no(log n) is optimal. We also provide a simpler proof of the result of Alekhnovich and Razborov (FOCS 2001) that unless the fixed parameter hierarchy collapses, tree-like resolution

Nitrogen and sulfur are key elements in the biogeochemical cycles of marine ecosystems to which benthic foraminifera contribute significantly. Yet, cell-specific assimilation of ammonium, nitrate and sulfate by these protists is poorly characterized and understood across their wide range of species-specific trophic strategies. For example, detailed knowledge about ammonium and sulfate assimilation

SARS-CoV-2 spike (S) protein is crucial for virus invasion in COVID-19. Here, we showed that lipopolysaccharide (LPS) can trigger S protein aggregation at high doses of LPS and S protein. We demonstrated the formation of S protein aggregates by microscopy analyses, aggregation and gel shift assays. LPS at high levels boosts the formation of S protein aggregates as detected by amytracker and thiofl

Background and Purpose: Clonal hematopoiesis of indeterminate potential (CHIP) is a novel age-related risk factor for cardiovascular disease-related morbidity and mortality. The association of CHIP with risk of incident ischemic stroke was reported previously in an exploratory analysis including a small number of incident stroke cases without replication and lack of stroke subphenotyping. The purp

Topics Covered - Genetic etiology- Autoantibodies as biomarkers- Autoantibodies predict clinical onset of diabetes- TEDDY study- DIPP study- Etiology and pathogenesis of type 1 diabetes- IAA-first or GADA-first

Background: The aggressive nature of breast cancers detected between planned mammographic screens, so-called interval cancers, remains elusive. Here, we aim to characterise underlying molecular features of interval cancer. Methods: From 672 patients with invasive breast cancer, we analysed gene expression differences between 90 ‘true’ interval cancer cases (i.e. women with low-dense breasts define

I present an empirically based argument for the plausibility of misrepresentation as posited by some higher-order theories of consciousness. The argument relies on the assumption that conscious states are generated by processes in the brain. The underlying idea is that if the brain generates conscious states then misrepresentation may occur. The reason for this is that brain states can be corrupte

Animals across phyla can detect early cues of infection in conspecifics, thereby reducing risk of contamination. It is unknown, however, if humans can detect cues of sickness in people belonging to communities with whom they have limited or no experience. To test this, we presented Western faces photographed two hours after the experimental induction of an acute immune response to one Western and

Foreign Direct Investment (FDI) is often considered to be favorable to long-run economic growth and has in recent years been promoted as a poverty-reducing tool. Although FDI to developing countries has increased rapidly in recent decades, Sub-Saharan Africa (SSA) has been unsuccessful in attracting large inflows of FDI. This study assesses the effect FDI has had on poverty and human development i

En av de mest revolutionerade tekniska innovationerna under de senaste decennierna har varit Blockkedjeteknologin. Sedan Bitcoins intåg i vardagslivet har blockkedjan blivit ett hushållsord, men trots det har juridiken ännu inte enats om hur denna teknologi bör integreras i samhället. En del ser teknologin som en metod för ytterligare säkerhet i det offentliga rummet, medan andra förutspår att tekOne of the most revolutionary technological innovations in the last few decades has been the block chain technology. Since the herald of Bitcoin into daily life, the block chain has become a household name, but despite that, the law has been lagging behind, providing no unified answer on how to integrate this technology into society. Some view the technology as a means of more secure public certif

Mass migrations are a phenomenon of all times. Notably, following the Second World War, there have been huge migration movements and decolonisation processes, particularly by the Germans and the Jews, but also by Roma and other groups. Parallel to that, in 1963, Protocol No. 4 to the Convention was signed, with Article 4 prohibiting the collective expulsion of aliens. In 2020, 3,6% of the populati

Title: Home is wherever your private equity firm takes you - A quantitative analysis comparing cross-border and domestic* transaction multiples in PE acquisitions of Nordic companies Seminar date: 30 May 2024 Course: NEKN02, Master Essay – Finance Programme, 15 ECTS Authors: Clarissa Nowak, Sofia Sjöholm Advisor: Jens Forssbaeck Keywords: Private Equity, Buyouts, Cross-Border, Valuation, Nord