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Type 1 diabetes (T1D) is an autoimmune disease associated with the destruction of pancreatic β cells and genetically linked to human leukocyte antigen (HLA) class II DR3-DQ2 and DR4-DQ8 haplotypes. The +49A/G polymorphism of the immunoregulatory cytotoxic T-lymphocyte antigen 4 (CTLA-4) gene is also associated with T1D. Genetic and environmental risk factors precede the onset of T1D, which is char
The first part of this paper discusses how Jesus is presented as a leader in the call narratives in the Gospel of Matthew (4.18–22). By making use of a biographical-narrative reading of Matthew, which takes the biographical genre seriously and pays attention to the narrative development of the story, and modern understanding of leadership, mainly by making use of transformational leadership theori
BOADICEA is a comprehensive risk prediction model for breast and/or ovarian cancer (BC/OC) and for carrying pathogenic variants (PVs) in cancer susceptibility genes. In addition to BRCA1 and BRCA2, BOADICEA version 6 includes PALB2, CHEK2, ATM, BARD1, RAD51C and RAD51D. To validate its predictions for these genes, we conducted a retrospective study including 2033 individuals counselled at clinical
In both the US and EU, policymakers and government agencies are acknowledging theimportance of having access to repair options, particularly for vulnerable product users who depend on their products. As such, repair can play an important role as a resource for resilience, but research is missing. We propose that repair can act as a resource for resilience. A comprehensive, structured way to unders
Recent studies have revealed asymmetries between the left and right sides of the brain in invertebrate species. Here we present a review of a series of recent studies from our laboratories, aimed at tracing asymmetries at different stages along the honeybee's (Apis mellifera) olfactory pathway. These include estimates of the number of sensilla present on the two antennae, obtained by scanning elec
Stable carbon isotope curves derived from Lower Triassic carbonate rocks from three Iranian sections are established to investigate changes in the carbon cycle during the Early Triassic in this area. The sections are located in the south-center (Abadeh), north (Amol), and northwest (Zal) of Iran. All three curves show a similar pattern starting out with high δ13C values in the uppermost Permian de
This Letter presents a search for highly ionizing magnetic monopoles in (Formula presented) of ultraperipheral (Formula presented) collision data at (Formula presented) collected by the ATLAS detector at the LHC. A new methodology that exploits the properties of clusters of hits reconstructed in the innermost silicon detector layers is introduced to study highly ionizing particles in heavy-ion dat
Numerical models of meteorite delivery from impacts on the Moon have demonstrated that the impact event forming the lunar crater Tycho (~85 km diameter; ca. 109 Ma age) would have delivered considerable amounts of ejected material to Earth. The ejecta, containing lunar Ti- and V-rich chrome spinels, would have been distributed globally and admixed with seafloor sediments over a few meters of a typ
Background. Seeking to clarify the parent-offspring transmission of Major Depression (MD) and type I Bipolar Disorder (BD), we examined offspring MD and BD risk in five informative parental pairs: Unaffected x MD, Unaffected x BD, MDxMD, MDxBD and BDxBD. Methods. We identified 289,637 individuals born in Sweden 1970-1990, followed through 2018, from parents with MD and/or BD identified from Swedis
Climate change is recognized as one of the greatest environmental threats facing the world today. To tackle this problem, a protocol was adopted in Kyoto in 1997 which establishes legally binding commitments to developed countries to bring down the emissions of six major greenhouse gases by 5.2% compared to the year 1990. Three flexibility mechanisms have been provided to developed countries to ac
Given the assumptions of rational choice, this essay explicates the distributive consequences of different ethical positions and how the relationship between eth-ics and distributions provides a rationale for a struggle for moral authority for the purpose of procuring distributive shares. The argument provides a partial answer to the question of why there is political struggle in all human societi
The World Health Organization rapports general low adherence to medical treatments in long term therapies among developed countries. The aim of this study was to analyse the individual variation in drug adherence to long term use. A set of individual data with people interviewed in year 2004/2005 was created from the Swedish Survey of Living Conditions and the Pharmaceutical Registry. The data set
The Swedish Society of Paediatric Infectious Diseases worked with paediatric societies for emergency medicine, anaesthesia, and intensive care to produce the 2025 recommendations for the initial management of suspected sepsis. They cover 28 days of corrected age to 18 years, but exclude immunodeficiency, immunosuppression, and suspected meningitis. Suspicion of sepsis and sepsis-associated shock i
BACKGROUND: Patients presenting with an acutely painful swollen joint represent a diagnostic challenge. We aimed to develop a clinical prediction model for septic arthritis (SA) in the adult native knee.METHODS: We screened all synovial cultures in south Sweden in 2020 and 2021. We included cultures taken in the emergency department from adults' native knees where SA was considered a differential
