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Lipids have been implicated in beta-cell stimulus-secretion coupling. In such a role, lipases in beta-cells would be required to generate lipid coupling factors. We have shown previously that glucose stimulates lipolysis in rodent islets. In addition, lipolysis and diacylglycerol lipase activity in islets are abolished by orlistat, an irreversible lipase inhibitor with a broad specificity for subs
Dipeptidyl peptidase (DPP)-4 inhibition is a glucose-lowering treatment for type 2 diabetes. The classical mechanism for DPP-4 inhibitors is that they inhibit DPP-4 activity in peripheral plasma, which prevents the inactivation of the incretin hormone glucagon-like peptide (GLP)-1 in the peripheral circulation. This in turn increases circulating intact GLP-1, which results in stimulated insulin se
This introductory article situates the contributions that comprise this special issue within the field of sustainable consumption and production (SCP) studies. After a brief review of the policy history surrounding SCP, we organize our discussion and the subsequent collection of articles into two groups. The first suite of articles views the environmental impacts associated with household consumpt
A formula is proposed for the longshore sediment transport in the swash based on the study by Larson et al. on swash-zone transport and foreshore evolution. Hydrodynamics needed to predict the local transport rate were derived from ballistics theory, where both the cases with and without friction were investigated. The formula was validated with data from two experiments carried out in the Large-s
This paper describes a novel tool for eliciting user requirements early in the design process of mobile applications. The "Mobile Oracle", as we have called it, is intended to help developers and designers obtain a better understanding of what the user wants at different points in space and time. It is an extension of a lo-fi version of the well-established Wizard of Oz technique, but it adds an "
The Bremmer series is used to reduce a complex scattering problem to a sequence of simpler single scattering problems. In the Bremmer series, the wave equation is first decomposed into a coupled system of one-way wave equations. The system is then decoupled into a sequence of one-way wave equations with a fixed point iteration. In this paper, a left symbol representation of the decomposition opera
The Writer:
Sigrid Combüchen was born in Solingen in the German Ruhr territory 1942. Shortly after the War her family moved to Sweden. She is a Swedish writer and literary critic and has so far published seven novels, a collection of essays and a biography (on the Norwegian novelist and winner of the Nobel Prize in Literature 1920, Knut Hamsun). She received the 2004 Selma Lagerlöf Prize a
This paper presents a readily computable formula for the real stability radius with respect to an arbitrary stability region in the complex plane.
This chapter proposes an onomasiological research methodology forcross-linguistic investigations of antonyms. The basic assumption is that thereis a number of strongly opposable lexical semantic pairings in all languages,whose meanings are central to human existence, e.g. speed slow–fast, luminosity, dark–light, strength weak–strong, size small–large. There is also a large number of other pairings
