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The utility of mRNA and protein determinations of G protein-coupled receptor 35, that is, GPR35a (GPR35 V1) and GPR35b (GPR35 V2/3), as indicators of outcome for colon cancer patients after curative surgery was investigated. Expression levels of V1 and V2/3 GPR35, carcinoembryonic antigen and CXCL17 mRNAs were assessed in primary tumours and regional lymph nodes of 121 colon cancer patients (stage
We have developed an assay, based on nanofluidic channels and fluorescence microscopy, for optical mapping of DNA based on competitive binding between two molecules - one fluorescent and one sequence selective. From the experimental data we can extract binding constants for the two competing DNA binders, which may be subsequently used to calculate a theoretical reference map of any DNA with known
Purpose: To assess the ability of quantitative pupillometry [using the Neurological Pupil index (NPi)] to predict an unfavorable neurological outcome after cardiac arrest (CA). Methods: We performed a prospective international multicenter study (10 centers) in adult comatose CA patients. Quantitative NPi and standard manual pupillary light reflex (sPLR)—blinded to clinicians and outcome assessors—
Dynamic glucose-enhanced (DGE) imaging uses chemical exchange saturation transfer magnetic resonance imaging to retrieve information about the microcirculation using infusion of a natural sugar (D-glucose). However, this new approach is not yet well understood with respect to the dynamic tissue response. DGE time curves for arteries, normal brain tissue, and cerebrospinal fluid (CSF) were analyzed
Mutations in the glucocerebrosidase (GBA) gene have been associated with the development of Parkinson's disease (PD). An induced pluripotent stem cell (iPSC) line was generated from a 60-year old patient diagnosed with PD and carrying a new mutation variant p.R301C in GBA. Using non-integrating Sendai virus-based technology, we utilized OCT3/4, SOX2, c-MYC and KLF4 transcription factors to reprogr
This paper presents and assesses the cooling integration of medium size electrical machines with distributed hair-pin type of windings. By introducing a hollow or profiled conductor the generated heat can be removed right where it is created. The cooling duct in conductor that can be connected either to series or parallel cooling flows increases DC resistance up to 1.5 times when comparing commerc
The international development community is transitioning from the era of the Millennium Development Goals (MDGs), ending in 2015, to the era of the Sustainable Development Goals (SDGs), which have a 2030 target. Global development assistance for health (DAH) increased substantially in the MDGs era, from US $10.8 billion in 2001 to $28.1 billion by 2012 (in 2010 US dollars), and it played a crucial
Background: This study investigates gaze behaviour in child dialogues. In earlier studies the authors have investigated the use of requests for clarification and responses in order to study the co-creation of understanding in a referential communication task. By adding eye tracking, this line of research is now expanded to include non-verbal contributions in conversation. Aims: To investigate
The research group from Humanities laboratory at Lund University, Sweden, presents three strands of research on language and cognition where eye-tracking methodology has been used as a window on the mind. The paper includes: (1) eye tracking studies on picture viewing and picture description showing the dynamics of how speakers perceive, conceptualize and spontaneously describe complex visual scen
Denna uppsats behandlar den fria rörligheten för varor i relation till det svenska alkoholmonopolet. Vidare ligger fokus på Systembolaget och dess framtid om gårdsförsäljning av alkoholdrycker blir tillåtet i Sverige. De bestämmelser som är relevanta i uppsatsens undersökning är artiklarna 34, 36 och 37 FEUF. De frågeställningar som uppsatsen följaktligen syftar till att besvara är för det första This paper deals with the free movement of goods in relation to the Swedish alcohol monopoly. Furthermore, the focus is on Systembolaget and its future if farm sales of alcoholic beverages is allowed in Sweden. The provisions relevant to the essay's examination are Articles 34, 36 and 37 TFEU. The questions that the paper thus aims to answer are firstly how articles 34 and 37 relate to each ot
Aerosolsammansättningen i ett renluftsområde i Mellansverige (Velen) har studerats under en årscykel. Aerosolpartiklarna har uppdelats efter aerodynamisk storlek i 7 fraktioner. Varje fraktion från 113 provtagningstillfällen har analyserats m a p svavel och tungmetaller m h a partikelinducerad röntgenstrålning s k PIXE-analys. Resultaten påvisar variationer i ämneskoncentrationer mellan enskilda m
Popular Abstract in Swedish Tjocktarmcancer är en av de vanligaste cancerformerna i västvärlden. I Sverige drabbas årligen ca 5000 människor. Ungefär 10% av fallen går att härleda till ärftliga faktorer medan den övervägande delen orsakas av miljöfaktorer. Kända riskfaktorer är fysisk inaktivitet, fetma och rökning. Risken för cancer påverkas dock mest av den kost vi äter. Allmänt kan sägas att enSphingomyelin (SM) is present both in eucaryotic cells and the diet. Sphingomyelinase (SMase) hydrolyses SM and generates ceramide that has been implicated in the regulation of cell growth, differentiation and apoptosis. Previously a SMase with alkaline pH optimum was identified in the intestinal tract. The thesis studied the distribution pattern, the species difference and the clinical implicatio
Popular Abstract in Swedish Robust konstruktion handlar om hur produkter skall konstrueras för att bli okänsliga mot oväntade störningar och variationer i t.ex. omgivningen under drift. Normalt har detta problem angripits med den sk. Taguchi-metoden, i vilken experiment utförs efter en viss metodik på en prototyp, varefter produktens beteende kartläggs och konstruktionsvariablerna väljs så att ettThe activity of robust design of mechanical products and how it can be accomplished in pre-prototype design phases, is discussed in this thesis. It is advocated that to be fully efficient and effective optimization of product robustness should commence already in the conceptual design phase. Moreover, since product optimization is a process, robust design should be perceived and implemented as a p
Popular Abstract in Swedish Blåsexstrofi är en ovanlig och mångfasetterad missbildning. I hela Sverige föds cirka tre barn om året med blåsexstrofi. Bukvägg och urinblåsa är öppna nedanför naveln, så att man ser blåsans insida samt rinnande urin. Flickorna har en delad clitoris, framflyttad och trång slidöppning samt framflyttad ändtarmsöppning. Pojkarna har en kort, öppen penis, som ligger uppfälBladder exstrophy is a complex malformation seen in 1/30 000. Most children are subject to repeated operations, including pelvic osteotomy, genital and bladder neck reconstruction and sometimes bladder augmentation or a urinary reservoir, to achieve continence and a normal genital function. A retrospective study of all Swedish children born 1970-89 showed a low continence rate, 17% , and a high r
In the present thesis, genetic abnormalities in pancreatic cancer were studied, with special emphasis on alterations of components involved in the transforming growth factor beta (TGFB) signaling pathway. In the first study, fluorescence in situ hybridization and cytogenetic analyses revealed aberrations of chromosome 18 in all 13 pancreatic carcinoma cell lines studied, in particular frequent bre
The term Anthropocene denotes a new geological epoch characterized by the unprecedented impact of human activities on the Earth’s ecosystems. While the natural sciences have advanced their understanding of the drivers and processes of global change considerably over the last two decades, the social sciences lag behind in addressing the fundamental challenge of governance and politics in the Anthro
Popular Abstract in Swedish Elektrocochleografi (ECoG) är en metod som mäter de elektriska signaler som uppstår i innerörat när örat stimuleras med ljud. Signalerna uppstår i snäckans sinnesceller, de så kallade hårcellerna, och i nervcellerna som utgår från snäckan. Snäckan är det organ som omvandlar ljudets mekaniska energi till elektriska signaler i hörselnerven. Hörselnerven förmedlar signalerElectrocochleography (ECoG) is an objective method to evaluate cochlear electrophysiology. The recordings are considered to reflect the mechano-electric processes of the cochlea, and can indicate the presence of suspected endolymphatic hydrops. The aim of the present thesis was to investigate the value of transtympanic (TT) ECoG in the clinical diagnosis and management of Menière´s disease. The tr
