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Assessment of respiratory tract deposition of nanoparticles is a key link to understanding their health impacts. An instrument was developed to measure respiratory tract deposition of nanoparticles in a single breath. Monodisperse nanoparticles are generated, inhaled and sampled from a determined volumetric lung depth after a controlled residence time in the lung. The instrument was characterized
Transforming growth factor-β (TGFβ) is a potent inhibitor of hematopoietic stem and progenitor cell proliferation. However, the precise mechanism for this effect is unknown. Here, we have identified the transcription factor Gata2, previously described as an important regulator of hematopoietic stem cell (HSC) function, as an early and direct target gene for TGFβ-induced Smad signaling in hematopoi
According to the Swedish higher ordinance of education the development of autonomy of PhD students is of high importance. Graduates should be able to formulate new ideas and to independently assess and evaluate scientific results. Therefore it is interesting to investigate how the relationship between student and supervisor impacts the development of autonomy. In this work, we have evaluated the i
Atrial natriuretic peptide (ANP) has a central role in regulating blood pressure in humans. Recently, microRNA 425 (miR-425) was found to regulate ANP production by binding to the mRNA of NPPA, the gene encoding ANP. mRNAs typically contain multiple predicted microRNA (miRNA)-binding sites, and binding of different miRNAs may independently or coordinately regulate the expression of any given mRNA.
Ever since the invention of the internal combustion engine, there has been an interest in optimizing the in-cylinder pressure to achieve reliable and efficient work output. With the use of in-cylinder pressure sensors, piezoelectric injector actuation, the possibility of multiple injection events and the increased availability of computation power, cycle-to-cycle, in-cylinder pressure optimization
Modelica allows systems to be described with reuseable components and with a high precision. To be able to use such complex models efficiently, high demands are set on tools that allow the user to extract the information needed from the models in a straight-forward manner. For this purpose, design-of-experiments techniques can be used to systematically analyze the complex models.In this paper, it
An unbroken digital data flow would save substantial resources in the built environment process. In this study, which is part of a larger Swedish project, data delivery specifications and methods to integrate BIM and geodata are developed and tested with the aim to facilitate such an unbroken data flow. The main focus areas of the study are: (1) specifications that enables building permission appl
Laser-induced incandescence (LII) is a versatile technique for quantitative soot measurements in flames and exhausts. When used for particle sizing, the time-resolved signals are analysed as these will show a decay rate dependent on the soot particle size. Such an analysis has traditionally been based on the assumption of isolated primary particles. However, soot particles in flames and exhausts a
An investigation into the implementation state of open standards in software is currently ongoing through the ISPRS/EuroSDR 'GeoBIM benchmark 2019' initiative, which kicked off earlier this year. The benchmark activity provides a way of assessing and comparing the functionality of different software packages in GIS and BIM in terms of their ability to handle standardised data (IFC and CityGML) and
In both the Geo and BIM domains, it is widely acknowledged that the integration of geo-data and BIM-data is beneficial and a crucial step in facing the multi-disciplinary challenges of our built environment. The result of this integration - broadly termed as GeoBIM - has a range of potential uses from district study to road safety. However, from the data perspective, this integration raises the qu
The aim of this paper is to present a proposal for a national building standard in Sweden. We define requirements for the proposed standard, e.g., it should support development of 3D city models, connect to building information models (BIM) and national registers and be based on a national classification system for the urban environment. Based on these requirements we develop an Application Domain
Partially Premixed Combustion (PPC) is an advanced combustion concept resulting in high efficiencies and low emission levels by the use of high levels of EGR and pilot injections. The main limitation of PPC to use in practice lies in the high pressure rise rate, which causes issues on engine noise and durability. In addition, soot emissions face with the overshoot problem during the transient oper
Partially Premixed Combustion (PPC) is a promising advanced combustion mode for future engines. In order to investigate the sensitivity of PPC to exhaust gas recirculation (EGR) rate, intake gas temperature, intake gas pressure, and injection timing, these parameters were swept individually at three different loads in a single cylinder diesel engine with gasoline-like fuel.A factor of sensitivity
Urgent structural change is required in higher education, to allow collaboration both within and across universities, so that achieving rapid sustainability transition can become not only the overarching but the main purpose of education, research and work in society. A review of the literature reveals that fragmentation caused by traditional hierarchical faculty and disciplinary organisation is a
Background: Exposure to airborne particles has a major impact on global health. The probability of these particles to deposit in the respiratory tract during breathing is essential for their toxic effects. Observations have shown that there is a substantial variability in deposition between subjects, not only due to respiratory diseases, but also among individuals with healthy lungs. The factors d
