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Background: Radiotherapy reduces the risk of local recurrence in rectal cancer. However, the optimal radiotherapy fractionation and interval between radiotherapy and surgery is still under debate. We aimed to study recurrence in patients randomised between three different radiotherapy regimens with respect to fractionation and time to surgery. Methods: In this multicentre, randomised, non-blinded,
BACKGROUND: In patients with sinus rhythm and normal atrioventricular conduction, pacing only the left ventricle with appropriate atrioventricular delays can result in superior left ventricular and right ventricular function compared with standard biventricular (BiV) pacing.OBJECTIVE: To evaluate a novel adaptive cardiac resynchronization therapy ((aCRT) algorithm for CRT pacing that provides auto
Objective: Electroconvulsive therapy (ECT) is one of the most efficient treatments for major depression. Electroconvulsive seizures (ECS), the animal model of ECT, is widely used to study both mechanisms of action and adverse effects of ECT. As the treatment itself serves as an instant anaesthetic and anaesthetic agents may affect memory functions and behaviour, ECS is traditionally administered w
Neural stem cells (NSCs) derived from human fetal striatum and transplanted as neurospheres survive in stroke-damaged striatum, migrate from the implantation site, and differentiate into mature neurons. Here, we investigated how various steps of neurogenesis are affected by intrastriatal transplantation of human NSCs at different time points after stroke and with different numbers of cells in each
The increasing rate of caesarean delivery is a worldwide concern. A major contributor to this evolution has been a concomitantly decline in vaginal birth after caesarean, because of the risk of intrapartum uterine rupture, which is a rare but potentially catastrophic complication of a trial of labour after caesarean (TOLAC). On the other hand, elective repeat caesarean is associated with surgical
In 2014 the Public Health Agency of Sweden and the Swedish Reference Group for Antiviral Therapy (RAV) conducted a review and analysis of the state of knowledge on the duration of follow-up after exposure to human immunodeficiency virus (HIV). Up until then a follow-up of 12 weeks after exposure had been recommended, but improved tests and new information on early diagnosis motivated a re-evaluati
New laser stepwise heating Ar-40-Ar-39 dates (415 +/- 1.8 and 414 +/- 2 Ma) from the Etive Dyke Swarm in the SW Grampian Highlands of Scotland indicate that the dykes are 10-20 Ma older than previously assumed. The dykes constitute the final phase of the Late Caledonian Granites in the region, which themselves define the end of the Caledonian Orogeny, therefore these dates can be taken as the end
Treatment with alkali, particularly overliming, has been widely used as a method for the detoxification of lignocellulose hydrolysates prior to ethanolic fermentation. However, the mechanisms behind the detoxification effect and the influence of the choice of cation have not been well understood. In this study, a dilute acid hydrolysate of spruce and an inhibitor cocktail consisting of six known i
Background: The study was designed to determine whether a 1-year hospital-based secondary prevention programme would have any long-term effects on serum lipid levels and the use of lipid-lowering drugs in patients with coronary artery disease 4 years after referral to primary care facilities for follow-up. Design/methods: After acute myocardial infarction or coronary bypass surgery, 241 consecuti
The FRR (Friendly Rest Room) project creates and evaluates prototypes of a more user friendly intelligent toilet for old persons and for persons with disabilities. Additionally, applicable knowledge regarding needs and wishes of old and/or disabled persons and their care persons are documented. In this paper the user driven research approach, ethical aspects and the iterative user centred design p
A search for four-top-quark production, tttt, is presented. It is based on proton-proton collision data with a center-of-mass energy s=13 TeV collected by the ATLAS detector at the Large Hadron Collider during the years 2015 and 2016, corresponding to an integrated luminosity of 36.1 fb-1. Data are analyzed in both the single-lepton and opposite-sign dilepton channels, characterized by the presenc
The Global Stratotype Section and Point (GSSP) defining the base of the Jurassic System Lower Jurassic Epoch and Hettangian Stage is situated at the Kuhjoch pass, Karwendel Mountains, Northern Calcareous Alps, Austria (47°29'02"N/11°31'50"E). The Triassic-Jurassic (T-J) boundary is exposed at Kuhjoch West and at Kuhjoch East, and corresponds to the first occurrence (FO)
Stimulated by a recent controversy regarding pressure drops predicted in a giant aneurysm with a proximal stenosis, the present study sought to assess variability in the prediction of pressures and flow by a wide variety of research groups. In phase I, lumen geometry, flow rates, and fluid properties were specified, leaving each research group to choose their solver, discretization, and solution s
Mineral evolution is concerned with the timing of mineral occurrences, such as the earliest reported occurrences in the geologic record. Minerals containing essential Li have not been reported from rocks older than ca. 3000 Ma, thus the lithian tourmaline (fluor-elbaite) and mica (lepidolite) assemblage from a pegmatite near Zishineni associated with the ca. 3000 Ma Sinceni Pluton presents unusual
In the remedial phase following an accidental radioactive release, it is important that soil decontamination measures are carried out on the areas that contribute most to the radiation dose. In this study, the newly developed concept of isodose lines was applied to the area around typical Swedish dwellings to identify these areas. The influence of the most common building materials in Sweden, wood
Purpose: The aim of the study was to compare overall survival (OS) and disease-free survival (DFS) after open and robotic radical hysterectomy for early-stage cervical cancer. Patients and methods: This was a nationwide population-based cohort study on all women with cervical cancer stage IA1-IB of squamous, adenocarcinoma or adenosquamous histological subtypes, from January 2011 to December 2017,
