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Introduction. The aim of this model study was to estimate and compare the risk of radiation-induced adverse late effects in pediatric patients with medulloblastoma (MB) treated with either three-dimensional conformal radiotherapy (3D CRT), inversely-optimized arc therapy (RapidArc ® (RA)) or spot-scanned intensity-modulated proton therapy (IMPT). The aim was also to find dose-volume toxicity param
The overall aim of thesis was to explore frail older people’s experiences of receiving healthcare and/or social services and to investigate healthcare consumption and costs in both men and women and in different age groups in the two years prior to the introduction of long-term municipal care. A second aim was to explore a preventive intervention in a pilot study using case managers to older peopl
Background: The commercialization of second-generation bioethanol has not been realized due to several factors, including poor biomass utilization and high production cost. It is generally accepted that the most important parameters in reducing the production cost are the ethanol yield and the ethanol concentration in the fermentation broth. Agricultural residues contain large amounts of hemicellu
Utmaningar kring samarbete och effektivt utnyttjande av den tvärprofessionella kompetensen har observerats i svenska elevhälsoteam. En kommun har adresserat dessa svårigheter genom att implementera ett gemensamt ramverk, Systematiskt Tillsammans för Lärande (STfL). Syftet med föreliggande studie var att utforska hur ett sådant gemensamt ramverk upplevs av elevhälsoteamens olika professioner vad gäCollaboration and efficient use of multidisciplinary competence has been observed to be difficult in student health teams (SHT) in Sweden. One municipality has addressed these issues by implementing a common framework, Systematically Together for Learning (STfL). The aim of this study was to explore how this framework was experienced by the student health service professionals in relation to imple
Practitioners primarily utilise nonparametric methods when estimating Value-at- Risk (VaR) and Expected Shortfall (ES) for computing capital requirements. However, various researchers assert that there are issues with those estimates, particularly amidst periods of market turmoil. Academia produces novel parametric methods to estimate extreme risk measures to address these deficiencies. Neverthele
In crisis-hit Greece, there have been an unprecedented rise of grassroots self-help initiatives for the last three to four years, and the whole phenomenon has come to be known as the quest for social and solidarity economy. With the consolidation of political and economic power in today’s capitalist market economy, the social and solidarity movement in Greece has been seeking for a way forward to
Activation-induced cytidine deaminase (AID) is an enzyme and key component of both 15 class-switch recombination and somatic hypermutation, two mechanisms used by activated B 16 cells to diversify their antigen repertoire, as it catalyzes the deamination of deoxycytidines turning 17 them into deoxyuridines, introducing mutations in immunoglobulin genes. AID, however, can also 18 target enhancer re
Bridges are critical assets within transportation networks, and their failure, whether due to accidental actions, extreme environmental events, or localized damage, can lead to consequences that extend far beyond the structure itself. In addition to direct safety implications, bridge failures often result in prolonged traffic disruption, economic losses, and reduced network resilience. As traffic
PURPOSE: Our purpose for this study is to describe and analyze the problems and challenges linked to measuring performance in activities directly and indirectly related to organizational purpose. METHODOLOGY: To map the issues and challenges connected to measuring performance based on organizational purpose we have used 8 case studies divided in following categories; 2 sectors (for-profit and nonp
In this paper, the moral duty towards asylum seekers and refugees in the EU is highlighted, from the perspectives of Universalism and Communitariarism. Due to different levels of safety and conditions related to being granted asylum in EU member states, the attractiveness of these states for asylum seekers and refugees to seek protection differ substantially. The implementation of the Dublin II Co
In order to systematize and rationalize the quality control process for FDS (Fire Dynamics Simulator) input data a software application for this specific purpose has been developed. In order to study the occurrence of user related errors in FDS input data and the possibility of reducing such errors by using the developed application, a case study on archived FDS input data from actual building pro
Direct laser writing (DLW) has arise interest in a variety of fields due to the capabilities that we get from the realization of 2D and 3D structures with high resolution fabrication techniques. Multi-photon lithography (MPL) relies on non-linear absorption effects, making possible the fabrication of metasurfaces with feature size beyond the diffraction limit. A new approach in this direction is t
Background: For up to 50% of adolescents experiencing PTSD, the course of their illness is further complicated by co-occurring substance use. Despite this, evidence-based integrated treatment options for adolescents with this comorbidity remain sparse. To address this gap, we are conducting an RCT examining the efficacy of exposure-based therapy for co-occurring PTSD and substance use among adoles
BACKGROUND: The recent discovery and specific functions of D-amino acids in humans are bound to lead to the revelation of D-amino acid abnormalities in human disorders. Therefore, high-throughput analysis techniques are warranted to determine D-amino acids in biological fluids in a routine laboratory setting. METHODS: We developed 2 chromatographic techniques, a nonchiral derivatization with chira
INTRODUCTION: Current pharmacological treatments of post-traumatic stress disorder (PTSD) have limited efficacy. Although the diagnosis is based on psychopathological criteria, it is frequently accompanied by somatic comorbidities and perhaps "accelerated biological aging," suggesting widespread physical concomitants. Such physiological comorbidities may affect core PTSD symptoms but are rarely th
PURPOSE: To analyze the incidence, risk factors, and outcomes of cataract surgery complicated by a dropped nucleus. SETTING: Patients who have received cataract surgery in 18 European countries. DESIGN: Retrospective cross-sectional register-based study. METHODS: Data from the European Registry of Quality Outcomes for Cataract and Refractive Surgery (EUREQUO) were analyzed. The EUREQUO contains pr
The Waste Electrical and Electronic Equipment Directive of the European Commission places the responsibility on producers to finance collection and treatment of waste deposited at collection facilities after 13 August 2005, on a collective or individual basis. For "historic" waste, put on the market before this date, producers are responsible for a proportion of their respective share of
