Search results

Cetuximab is an epidermal growth factor receptor (EGFR)-targeting drug that has shown effects in head and neck squamous cell carcinoma (HNSCC). The effects are, however, small and have mainly been proven in a subset of patients, and the cost-effectiveness has been questioned. For this reason, we need to know more about the basic mechanisms controlling the effect of EGFR signalling on tumour growth

The northern terrestrial net ecosystem carbon balance (NECB) is contingent on inputs from vegetation gross primary productivity (GPP) to offset the ecosystem respiration (R-eco) of carbon dioxide (CO2) and methane (CH4) emissions, but an effective framework to monitor the regional Arctic NECB is lacking. We modified a terrestrial carbon flux (TCF) model developed for satellite remote sensing appli

Socioeconomic status could potentially impact on which type of rheumatic diagnosis a patient receives. We determined whether different socioeconomic status is a risk factor for being diagnosed with spondyloarthritis (SpA) or chronic pain. In a nested case-control study, we identified two sets of adult cases diagnosed with (i) SpA (n = 1,194) and (ii) chronic pain (n = 3,730) during 2010-2012 in Sk

Early exiting from the labor force and into disability pension (DP) represents a major social problem in Sweden and elsewhere. We examined how being asymmetric (A-SGA) or symmetric (S-SGA) small for gestational age predicts transitioning into DP. We analyzed a longitudinal sample of 8125 men and women from the Stockholm Birth Cohort (SBC), born in 1953 and not on DP in 1990. The SBC consists of da

Understanding uncertainties and sensitivities of projected ecosystem dynamics under environmental change is of immense value for research and climate change policy. Here, we analyze sensitivities (change in model outputs per unit change in inputs) and uncertainties (changes in model outputs scaled to uncertainty in inputs) of vegetation dynamics under climate change, projected by a state-of-the-ar

Here we present a toolbox for natural language processing tasks related to SARS-CoV-2. It comprises English dictionaries of synonyms for SARS-CoV-2 and COVID-19, a silver standard corpus generated with the dictionaries and a gold standard corpus of 10 Pubmed abstracts manually annotated for disease, virus, symptom and protein/gene terms. This toolbox is freely available on github and can be used f

Mathematical modelling is an important part of nuclear medicine. Therefore, several chapters of this book have been dedicated towards describing this topic. In these chapters, an emphasis has been put on describing the mathematical modelling of the radiation transport of photons and electrons, as well as on the transportation of radiopharmaceuticals between different organs and compartments. It al

The language that individuals use for expressing themselves contains rich psychological information. Recent significant advances in Natural Language Processing (NLP) and Deep Learning (DL), namely transformers, have resulted in large performance gains in tasks related to understanding natural language. However, these state-of-the-art methods have not yet been made easily accessible for psychology

Spring water, however, is often formed in complex geological formations and therefore it is difficult to determine the catchment area contributing to the flow. The Sayanokami spring, located in western part of Fukuoka City, Japan, is such a spring and an important water resource for the local agriculture. In order to better understand the hydrological properties of infiltration and groundwater pro

Abnormally phosphorylated tau proteins are known to be a major indicator of Alzheimer's Disease (AD) with strong association with memory loss and cognitive decline. Automated generation of pixel-wise accurate neurofibrillary tangles (NFTs) and neuropil threads (NTs) segmentation is a challenging task, due to lack of ground truth segmentation data of these abnormal tau pathology. This problem is mo

The construction sector is of great importance to the Swedish economy, but its impact on the climate is significant and the sector accounts for about 40% of Sweden's total energy consumption. The sector also generates a significant share of the total material flows and waste quantities in the society. Thus, due to the large impact of the construction sector, there are great opportunities to contri

Psykologiska evidensbaserade interventioner som förmedlas via internet och mobila teknologier (Digital Mental Health) har potential att minska tröskeln för att få vård, samt minska svårigheter att få tillgång till behandling på grund av avstånd, kostnader, arbete och familjekonflikter eller begränsad kapacitet hos vårdgivare. Den här typen av hinder utgör en särskild utmaning för personer med deprEvidence-based psychological interventions delivered via the internet and mobile technologies (Digital Mental Health) hold the promise of reducing barriers to care, including difficulties accessing treatment because of distance, cost, work and family commitments, and limited provider capacity. Such barriers represent a particular challenge for individuals with depression and anxiety, that tend to

BACKGROUND: Numerous laboratory tests are used in the diagnosis and management of patients with diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. An expert committee compiled evidence-based recommendations for laboratory analysis in patients with diabetes. The overall quality of the evidence and the strength of the recommendations we

BACKGROUND Numerous laboratory tests are used in the diagnosis and management of patients with diabetes mellitus. The quality of the scientific evidence supporting the use of these assays varies substantially. An expert committee compiled evidence-based recommendations for laboratory analysis in patients with diabetes. The overall quality of the evidence and the strength of the recommendations wer