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We have previously shown that selective heavy meromyosin (HMM) adsorption to predefined regions of nanostructured polymer resist surfaces may be used to produce a nanostructured in vitro motility assay. However, actomyosin function was of lower quality than on conventional nitrocellulose films. We have therefore studied actomyosin function on differently derivatized glass surfaces with the aim to
Appearance of dyskinesia is a common problem of long-term l-DOPA treatment in Parkinson's disease patients and represents a major limitation for the pharmacological management of the motor symptoms in advanced disease stages. We have recently demonstrated that dopamine released from serotonin neurons is responsible for l-DOPA-induced dyskinesia in 6-hydroxydopamine (6-OHDA)-lesioned rats, raising
The Ebf (O/E) family of helix-loop-helix transcription factors plays a significant role in B lymphocyte and neuronal development. The three primary members of this family, Ebf1, 2, and 3, are all expressed in adipocytes, and Ebf1 promotes adipogenesis when overexpressed in NIH 3T3 fibroblasts. Here we report that these three proteins have adipogenic potential in multiple cellular models and that p
The oscillations between glacial and interglacial climate conditions over the past three million years have been characterized by a transfer of immense amounts of water between two of its largest reservoirs on Earth - the ice sheets and the oceans. Since the latest of these oscillations, the Last Glacial Maximum (between about 30,000 and 19,000 years ago), similar to50 million cubic kilometres of
Effective utilization of the spatial domain enhances the capacity of a mobile radio network. A common technique is to use sector antennas, where the sectors are formed by weighting the outputs from the antenna elements. This results in spatial domain selectivity, which significantly improves the signal-to-(noise and interference) ratio in the received signals. However, the operation of the sector
The purpose of this work is to develop and implement a simple and robust preservation technology that can enhance food and economic security and thereby improve the lives of people in developing countries. The technique under development is termed “solar assisted pervaporation (SAP)”. It is a sustainable technology whereby fruit juices or purées are concentrated using reusable pouches made of “bre
In this study, we systematically assess the spatial variability in carbon and nitrogen balance simulations related to the choice of global circulation models (GCMs), representative concentration pathways (RCPs), spatial resolutions, and the downscaling methods used as calculated with LPJ-GUESS. We employed a complete factorial design and performed 24 simulations for Europe with different climate i
In this work we implement features for IEEE 802.11ac in the NS-3 simulator, in particular wider channels and bit-error calculations for higher modulation coding schemes. We also implement four wireless LAN deployment scenarios from the 802.11ax working group scenario document, and evaluate their performance under different operating conditions. Our simulation results demonstrate that many nodes in
Summary: This study examines the impact of smoking and smoking cessation on fracture risk in 75-year-old women followed for 10 years. Smoking increased fracture risk, especially for vertebral fractures. Smoking cessation decreased the risk for vertebral fractures but not for other fracture types. Introduction: The purpose of this study was to examine effects of smoking and smoking cessation on fra
Background: With a yearly incidence of 56 per 100,000 inhabitants, colorectal cancer (CRC) is one of the most common malignancies in the Western world, representing the third leading cause of cancer-related mortality. Within three years after the diagnosis of CRC, 29% of patients will have developed liver metastases. Liver resection is a possibly curative treatment, and several preoperative strate
Emergency decision makers face a challenge taking rapid and high-risk decisions during an emergency situation, especially when the emergency is cross-border and requires multi-agency cooperation. The emergency decision makers use emergency management (EM) system and sometimes decision support systems (DSS) when responding to a crisis. To date the emergency decision makers have not had access to a
PalCom is a pervasive middleware that can be used to assemble services provided by networked devices into configurations, called assemblies, for specific use cases by the user. In this dissertation, we present the development of a networking media abstraction framework for PalCom that abstracts different network interfaces in a PalCom device to upper layers of PalCom. The media abstraction framewo
Breast cancer is the most common cancer among women worldwide, although the mortality rates have decreased in the last decades. Breast cancer is a heterogeneous disease, and treatment resistance is a significant clinical problem in spite of the overall high survival rates. Improved screening programs, novel surgical techniques, and adjuvant treatments have contributed to the improved survival,
Environmental research infrastructures (RIs) support their respective research communities by integrating large-scale sensor/observation networks with data curation services, analytical tools and common operational policies. These RIs are developed as pillars of intra-and interdisciplinary research, however comprehension of the complex, pathologically interconnected aspects of the Earth's ecosyste
A promising approach for addressing sustainability problems is to recognize the unique conditions of a particular place, such as problem features and solution capabilities, and adopt and adapt solutions developed at other places around the world. Therefore, research and teaching in international networks becomes critical, as it allows for accelerating learning by sharing problem understandings, su
The Value of a Statistical Life (VSL) is a widely used measure of the value of mortality risk reduction. Since VSL should reflect preferences and attitudes to risk, there are reasons to believe that it varies depending on the type of risk involved. It has been argued that cancer should be considered a “dread disease”, which supports the use of a “cancer premium”. The objective of this study is to
Background It has been proposed that cancer is more common in some families than in others, but the hypothesis lacks population level support. We use a novel approach by studying any cancers in large threegeneration families and thus are able to find risks even though penetrance is low. Methods Individuals in the nation-wide Swedish Family- Cancer Database were organised in three generations and t
Peatland net ecosystem production is a key variable to assess changes in the functional role of peatlands in the global carbon cycle. Light use efficiency (LUE) models in combination with satellite data have been used to estimate production for most major ecosystems, but peatlands have been largely ignored. The objectives of this study were: 1) to examine how the LUE parameter epsilon, ε (the amou
