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Results of a phase I/II study of ocrelizumab, a fully humanized anti-CD20 mAb, in patients with relapsed/refractory follicular lymphoma
Background: Ocrelizumab is a humanized anti-CD20 antibody with increased antibody-dependent cellular cytotoxicity compared with rituximab. This phase I/II study evaluated its safety and efficacy in patients with relapsed/refractory follicular lymphoma (FL) after prior rituximab therapy. Design and methods: Forty-seven patients were treated in three dose cohorts and received eight infusions every 3
Streptococcus pyogenes secreted enzymes interacting with the human host
Streptococcus pyogenes is one of the most common bacteria infecting humans. One of the factors contributing to the disease-causing properties is the secreted streptococcal cysteine proteinase, SpeB, which degrades several host proteins in connective tissue and circulation. SpeB activity depends on the transformation from an inactive precursor, zymogen, into a mature proteinase. We show that
Potentialities of manganese ore and iron-carbon particles for pharmaceuticals and personal care products removal in electroactive constructed wetland
This study explores the use of manganese ore, iron-carbon particles (Fe-C), and gravel as anode fillers in electroactive constructed wetlands (ECWs) to treat wastewater containing pharmaceuticals and personal care products (PPCPs) including ciprofloxacin (CIP), ofloxacin (OFL), and naproxen (NPX), while also assessing bioelectricity production. Although the presence of PPCPs reduced pollutant remo
Development and validation of a novel Simoa assay for NPTX2 in Alzheimer's disease and Down syndrome
INTRODUCTION: Synaptic dysfunction and loss are pathological hallmarks of neurodegenerative diseases. Neuronal pentraxin 2 (NPTX2), a presynaptic protein involved in synaptic plasticity, has been linked to cognitive decline in Alzheimer's disease (AD) and other neurodegenerative disorders. METHODS: We developed and validated a novel single molecule array (Simoa) for NPTX2 in cerebrospinal fluid, w
Group G streptococcal IgG binding molecules FOG and protein G have different impacts on opsonization by C1q
Recent epidemiological data on diseases caused by beta-hemolytic streptococci belonging to Lancefield group C and G ( GCS, GGS) underline that they are an emerging threat to human health. Among various virulence factors expressed by GCS and GGS isolates from human infections, M and M-like proteins are considered important because of their anti-phagocytic activity. In addition, protein G has been i
Sushi domain-containing protein 4 (SUSD4) inhibits complement by disrupting the formation of the classical C3 convertase.
Many group A streptococcal strains express two different immunoglobulin-binding proteins, encoded by closely linked genes: characterization of the proteins expressed by four strains of different M-type
Structural determination of Streptococcus pyogenes M1 protein interactions with human immunoglobulin G using integrative structural biology
Streptococcus pyogenes (Group A streptococcus; GAS) is an important human pathogen responsible for mild to severe, life-threatening infections. GAS expresses a wide range of virulence factors, including the M family proteins. The M proteins allow the bacteria to evade parts of the human immune defenses by triggering the formation of a dense coat of plasma proteins surrounding the bacteria, includi
Konflikter i trafikplaneringsprocessen- En studie om hur intressekonflikter påverkar planeringsprocessen för ett hållbart transportsystem i Västra Hamnen.
Efficacy of T-cell assays for the diagnosis of primary defects in cytotoxic lymphocyte exocytosis
Primary hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder associated with autosomal recessive variants in genes required for perforin-mediated lymphocyte cytotoxicity. A rapid diagnosis is crucial for successful treatment. Although defective cytotoxic T lymphocyte (CTL) function causes pathogenesis, quantification of natural killer (NK)–cell exocytosis triggered by K562 targe
Wave
EXPLORING SOUND SOLASTALGIA The piece “Wave - exploring sound solastalgia” for the Sound Bench seeks to give sense and explore basic affects related to our sonically changing life worlds Nature sounds are often seen as relaxing, and understood as reconnecting our minds and bodies with something primeval. Such sounds are used for stress recovery in the fields of medicine and psychology, as well as
https://www.lmc.lu.se/en/sound-bench/wave - 2026-05-31
Schema mven14 2018x
MILJÖVETENSKAP Preliminärt schema 181001 Kurs: Tillämpad Miljövetenskap Kursansvarig: Håkan Wallander Lärare: Håkan Wallander (HW), Radhlinah Aulin (RA), Per-Erik Isberg (PEI), Deniz Koca (DK), Johanna Alkan Olsson (JAO) Lokaler: Vitmossan, Ekologihuset, Sölvegatan 37, se karta över kurslokaler Litteratur: Studieteknik: Läs om studieverkstaden Studenträttigheter: Läs om dina rättigheter och skyldi
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/schema_mven14_2018x.pdf - 2026-06-01
Schema mven14 2018x 0
MILJÖVETENSKAP Preliminärt schema 181001 Kurs: Tillämpad Miljövetenskap Kursansvarig: Håkan Wallander Lärare: Håkan Wallander (HW), Radhlinah Aulin (RA), Per-Erik Isberg (PEI), Deniz Koca (DK), Johanna Alkan Olsson (JAO) Lokaler: Vitmossan, Ekologihuset, Sölvegatan 37, se karta över kurslokaler Litteratur: Studieteknik: Läs om studieverkstaden Studenträttigheter: Läs om dina rättigheter och skyldi
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/schema_mven14_2018x_0.pdf - 2026-06-01
Sportens egen domstol: Hot mot idrottarnas rätt till en rättvis rättegång? - Analys av The Court of Arbitration for Sport i förhållande till art. 6.1 EKMR
The Court of Arbitration for Sport (CAS) is a global arbitration court which has ruled in sports law since its establishment in 1981. The arbitration court is the main court in sport disputes and acts as the last resort where subjects of sport can appeal decisions from different sport bodies to which they are bound and that includes an arbitration clause to CAS in the relevant statute. Although pa
Court of Arbitration for Sport och rätten till ett effektivt rättsmedel - En analys av det obligatoriska skiljeförfarandet i ljuset av EU-domstolens dom i mål C-600/23
A constant increase in sports-related disputes in the 1980s resulted in the establishment of the Court of Arbitration for Sport (CAS), which since then has played a central role as the highest arbitration court for sports-related disputes. A large part of the disputes before the CAS are due to arbitration clauses in the statutes of sports organisations, through which the arbitration procedure beco
Energy Storage & Conversion
Sustainable energy storage and conversion explores innovative methods to efficiently store and transform energy from various renewable sources. It focuses on technologies like advanced batteries, hydrogen production, fuel cells, and thermochemical systems as well as safety aspects of battery storage systems. Research aims to enhance energy density, reduce costs, and improve scalability, enabling r
https://www.energy.lth.se/research/energy-storage-conversion - 2026-05-31
No title
What a syllable can tell us on language Joana Rosselló joana.rossello@ub.edu University of Barcelona Language is a system of discrete infinity (DI). Any human being can cope with an infinite number of sentences (syntax) and chunks of well-formed sound/gesture sequences (phonology). Any human has also at his/her disposal an open-ended lexicon. In this paper I put forward the proposal that DI relies
Sammanfattning workshopbord 18okt2017
Workshop 18 oktober 2017: Ett hållbart Lunds universitet Dokumentation från Workshopen Framtidens hållbara universitet 18 oktober 2017 Workshopen var en del av vetenskapsveckan Framtidens universitet som arrangerades av Lunds universitet 16–22 oktober 2017. Workshopen arrangerades av Lunds universitets Hållbarhetsforum i samarbete med bland annat miljöavdelningen vid Lunds universitet, LUCSUS (Lun
https://www.hallbarhet.lu.se/sites/hallbarhet.lu.se/files/sammanfattning_workshopbord_18okt2017.pdf - 2026-06-01
Sammanfattning workshopbord 18okt2017 1
Workshop 18 oktober 2017: Ett hållbart Lunds universitet Dokumentation från Workshopen Framtidens hållbara universitet 18 oktober 2017 Universitetet är en viktig drivkraft för en bättre värld genom både vår forskning och vår utbildning. Samtidigt belastar vi miljön genom vår verksamhet – lokaler, resor, allt det vi konsumerar och så vidare. Som en del av programmet under den sista vetenskapsveckan
https://www.hallbarhet.lu.se/sites/hallbarhet.lu.se/files/sammanfattning_workshopbord_18okt2017_1.pdf - 2026-06-01
