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Molecular mapping of epitopes for interaction of HIV-1 as well as natural ligands with the chemokine receptors, CCR5 and CXCR4.
OBJECTIVE: Mapping coreceptor epitopes used by the prototypic R5 and X4 strains, HIV-1BaL and HIV-1IIIB, in comparison with epitopes involved in the activation and signaling induced by the natural ligands, RANTES and SDF-1beta. DESIGN: Receptor hybrids between CCR5 and CXCR4 were constructed. METHODS: Using single-overlap and extension PCR, increasing portions of CCR5 were replaced with correspond
Maturation of the intestinal epithelial barrier in neonatal rats coincides with decreased FcRn expression, replacement of vacuolated enterocytes and changed Blimp-1 expression
Experiments and Large Eddy Simulation of Supersonic Combustion in the Small-Scale Flight Experiment
Supersonic combustion is a critical area of research for advancing high-speed flight technologies, particularly for the development of scramjet engines for hypersonic vehicles. This study employs Finite Rate Chemistry (FRC) Large Eddy Simulation (LES) together with different experimental techniques to study the supersonic flow and thermochemical processes in the Small Scale Flight Experiment (SSFE
Allergen-Specific Immunotherapy Alters the Frequency, as well as the FcR and CLR Expression Profiles of Human Dendritic Cell Subsets.
IgG Glycan Hydrolysis Attenuates ANCA-Mediated Glomerulonephritis
The carbohydrate switch between pathogenic and immunosuppressive antigen-specific antibodies.
Cleavage of IgG1 and IgG3 by gingipain K from Porphyromonas gingivalis may compromise host defense in progressive periodontitis.
Serum Complement Activation by C4BP-IgM Fusion Protein Can Restore Susceptibility to Antibiotics in Neisseria gonorrhoeae
Neisseria gonorrhoeae is the etiological agent of gonorrhea, the second most common bacterial sexually transmitted infection worldwide. Reproductive sequelae of gonorrhea include infertility, ectopic pregnancy and chronic pelvic pain. Most antibiotics currently in clinical use have been rendered ineffective due to the rapid spread of antimicrobial resistance among gonococci. The developmental pipe
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The aim of present study was to arrange an experimental rabbit model for IgA-nephropathy. To this purpose, an approach was attempted which was previously successfully applied in rabbits, aiming for induction of post-streptococcal glomerulonephritis (PSGN). To induce the nephropathy, we used two Streptococcus pyogenes strains of M4 and M60 serotypes which showed differential IgA-binding capacity me
‘Quality Time’ in Nanny Families : Local Care Loops and New Inequalities in Sweden
Political initiatives such as tax deductions for domestic services including nannies have, together with a growing au pair market, paved the way for new possibilities of organizing child care and parenting in Sweden. This affects everyday ‘local care loops’ for the upper-middle-class families purchasing the services, as the logistics of solving the work-family dilemma change with the possibility o
GAD65-specific autoantibodies enhance the presentation of an immunodominant T-cell epitope from GAD65
GAD65 autoantibodies (GAD65Ab) are highly prevalent in type 1 diabetes, but their functional role in the pathogenesis of the disease and their relationship to T-cell reactivity to GAD65 is still unclear. We tested the hypothesis that GAD65Ab modulate presentation of GAD65 to T-cells. T-cell hybridoma T33.1, which recognizes the GAD65 274-286 epitope in the context of HLA-DRB1*0401, was incubated w
‘The Little Engine That Could’: A Qualitative Study of Medical Service Access and Effectiveness among Adolescent Athletics Athletes Competing at the Highest International Level
Absorption of blocking activity from human tumor‐bearer sera by staphylococcus aureus, cowan I
Production and Functional Characterization of Der p 1-Specific Human Recombinant IgE
Ny forskning bidrar till ökad förståelse av allergiska reaktioner Allergi har ökat dramatiskt under de senaste åren. Det är därför högst väsentligt att få ökad kunskap om hur beståndsdelarna i immunförsvaret hos allergiska personer samspelar. Förekomsten av allergi har kommit att öka dramatiskt under de senaste åren och har blivit ett betydande problem för folkhälsan. Allergi drabbar en så stor dThe prevalence of allergic disease is continuing to increase worldwide, and it has even become a major concern in public health. Allergic reactions are developed to otherwise harmless substances and may be both life-threatening as well as discomforting for patients in their daily life. Therefore, a more detailed knowledge about how antibodies interact with allergens and effector cells in allergic
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How do we talk about forestry? Policy misconceptions and media conflicts
Protecting Ecological Integrity in Transboundary Watercourses : An Integrational Approach towards Implementing Environmental Flows
The thesis explores the obligation in international law to protect the ecological integrity of transboundary watercourses. The thesis specifically examines the obligation to protect environmental flows, which essentially means to protect a certain water flow for the benefit of freshwater ecosystems and the ecosystem services they supply. The obligation to protect the integrity of transboundary wat
Breeding potential of Mentha accessions using rapid volatile organic compound-based metabotyping
The genus Mentha is highly valued in pharmaceutical, culinary, and personal care industries due to its rich aromatic and pharmacological traits. However, its complex taxonomy and genetic diversity create challenges for breeding programs focused on aroma and therapeutic qualities. To address these challenges, this study developedand validated a rapid, semi-quantitative metabotyping method to effici