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IDO1 can be induced by interferon gamma (IFN-γ) in multiple cell types. We have earlier described that the DNA methyltransferase inhibitor zebularine also induces IDO1 in several rat cell clones. We now describe a synergistic induction of IDO1 expression by IFN-γ and zebularine. To elucidate the mechanism of the IDO1 induction we have studied the methylation status in the promoter region of the ID
OBJECTIVES:: To compare the plasma volume (PV) expanding effect of a fast infusion rate with that of a slow infusion rate of a fixed volume of 5% albumin, of the synthetic colloids, 6% hydroxyethyl starch 130/0.4 and 4% gelatin, and of 0.9% NaCl in a rat sepsis model and to compare the plasma-expanding effect among these fluids. DESIGN:: Prospective, randomized animal study. SETTING:: University h
Results are presented of a search for any particle(s) decaying to six or more jets in association with missing transverse momentum. The search is performed using 1.34 fb(-1) of root s = 7TeV proton-proton collisions recorded by the ATLAS detector during 2011. Data-driven techniques are used to determine the backgrounds in kinematic regions that require at least six, seven or eight jets, well beyon
A search is presented for production of dark-matter particles recoiling against a leptonically decaying Z boson in 20.3 fb(-1) of pp collisions at root s = 8 TeV with the ATLAS detector at the Large Hadron Collider. Events with large missing transverse momentum and two oppositely charged electrons or muons consistent with the decay of a Z boson are analyzed. No excess above the Standard Model pred
This study employs an approach to policy as discourse and examines the construction of gender equality in the EU Gender Action Plan II. Drawing from the poststructural premise that discourses affect how issues are being thought about and acted upon, the study seeks to scrutinize how gender equality is attributed with meaning by applying Carol Bacchi’s analytical methodology What’s the problem repr
Corporations and in particular large multinational enterprises are important for every countries economic growth. However, exploitation and human rights abuses due to corporate activity are repeatedly occurring in states that lacks the proper legislation, enforcement or institutions to ensure human rights protection. Thus, there is an increasing call for lead firms of MNEs to exercise human rights
Disaster response is most effective, if a high level of preparedness is in place before natural hazards strike. As many low-income countries are under-financed when it comes to Disaster Risk Reduction, it is lower-cost interventions such as Community-Based Preparedness Trainings that they often rely on to provide strategies to reduce the vulnerability of communities. These trainings are widely use
The European energy transition entails opportunities to mitigate two of the EU’s most pressing current challenges: climate change and the energy crisis due to the dependency on fossil fuel imports. The EU has committed to limiting global warming to 2°C (preferably 1.5°C), compared to pre-industrial levels. In the context of the European Green Deal, the EU has set the objective to reach climate neu
PET waste is the most visible environmental threat in the Maldives, a Small Island Developing State (SIDS). The thesis aims to propose the deposit refund system as a policy intervention, and evaluates the feasibility of introducing the system in the Maldives. In order to see how other SIDS have implemented the policy, the research uses policy evaluation framework to analyse the implementation mech
Under the growing influence of dominant discourses such as ecological modernisation and neo- liberalisation, proposed alternative conservation approaches focus more and more on efficiency. In the realm of biodiversity conservation, synthetic biology - the application of engineering to facilitate and accelerate the design or modification of genetic materials in living organisms – has emerged as an
Many citizens in Ranchi, Jharkhand, suffer from the consequences of contaminated drinking water. The city’s water governance system therefore urgently needs to find ways to bring safe drinking water to its people. Prevalent models in water governance however do not provide effective guidance for the necessary transition process. They lack heuristics that facilitate an in-depth understanding of con
One of the target goals for sustainable development is the reduction of maternal mortality, which is a big health issue in some countries. Even if the research on maternal health care has come far and with the right expertise and supplies, almost all maternal deaths would be preventable. A working force to reduce the issues within maternal mortality in many countries are non-governmental organizat
This paper evaluates the impact of state visits on export flows and the specific role of the head of state based on the five Nordic countries: Denmark, Finland, Iceland, Norway, and Sweden. We construct a complete and comprehensive dataset containing all outgoing state visits from the Nordic countries between 1973 and 2022. Our main empirical strategy is to apply a difference-in differences (DiD)
Information and communication technology has emerged significantly over the past two decades. The ever-growing trade and monetization of digital encounters are likely to extend technology even more in the upcoming decades. Recent technological developments have brought various advantages worldwide, such as effective communication, increased production, and artificial intelligence, which can solve
This study examines whether the right to respect for private and family life, as enshrined in Article 8 of the European Convention of Human Rights, is equally enjoyed by transgender people. The focus of the research is on the European Court of Human Rights’ case law on gender identity, and special emphasis is placed on the principles of equality and non-discrimination. For the analysis, the Europ
Thesis purpose: The purpose of this study is to investigate the interdependencies within the process of partner selection in the fashion and design sector and the emanating criteria for finding the ideal co-branding partner in order to use co-branding as a strategic brand activation tool. Methodology: Multiple Case Study Theoretical perspective: Brand Building and Brand Activation, Relationship Ma
