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Electrostatic interactions play crucial roles in protein function. Measuring pKa value perturbations upon complex formation or self-assembly of e.g. amyloid fibrils gives valuable information about the effect of electrostatic interactions in those processes. Site-specific pKa value determination by solution NMR spectroscopy is challenged by the high molecular weight of amyloid fibrils. Here we rep
The performance of a new type of X-band Weather Radar (WR) for Sweden during a pilot run is studied. Compared to the conventional C-band WRs, the X-band WR covers a smaller area but with a higher spatiotemporal resolution, making it suitable for urban hydrological applications. Rainfall estimations from different elevation angles of the radar (levels) are compared at one-minute and single-event ti
På grund av svåra metodologiska och praktiska svårigheter domineras forskning om bolagsstyrning i allmänhet och styrelseeffektivitet i synnerhet av relativt ytliga modeller. Så kallade black boxstudier är mycket vanliga, och kontrasteras mest av rent konceptuella modeller utan kvantitativa amibitioner. Den här uppsatsen kikar in i den svarta lådan och utforskar den interpersonella kontexten i styrDue to severe methodological and practical difficulties, research on corporate governance in general and board performance in particular is dominated by relatively shallow models. So called black box studies are very common, and are contrasted mainly by conceptual models without any quantitative ambitions. This paper peeks into the black box, exploring the interpersonal context within the board ro
Denna uppsats syftar till att fastställa hur införandet av Enhetliga Patent och den Europeiska- och EU-patentdomstolen kommer att påverka läkemedelsindustrins val av patentansökningsförfarande när de ansöker om patent i Europa i framtiden. För att fastställa de förväntade effekterna av Enhetliga Patent på branschen har intervjuer med ett urval personer inom forskning- och utvecklingsföretag och enThis thesis aims to establish how the introduction of the Unitary Patent and the European and European Union Patent Court will affect the pharmaceutical industry’s choice of patent application route when applying for patents in Europe in the future. To establish the expected effect of the Unitary Patent on the industry interviews with a selection of professionals in the research and development in
Lag(1993:387) om stöd och service till vissa funktionshindrade trädde i kraft den första januari 1994 som en rättighetslag. Syftet var att människor med funktionsnedsättning skulle få ökad livskvalitet. Genom lagen ville samhället skapa en möjlighet för de som får insatser ”att leva ett liv som andra”. Lagen var planerad som en del av en helhet, där handikappolitikens generella och individuella deLag (1993:387) om stöd och service till vissa funktionshindrade, which is an Act of individual rights, came into effect in January 1994. Its purpose was to improve the quality of life for people with disabilities and to create opportunities for people with disabilities to enable to live a life like any other. The Act was intended to be a part of a whole in which the general and individual parts of
Building interaction prototypes for ubiquitous computing is inherently difficult, since it involves a number of different devices and systems. Prototyping is an important step in developing and evaluating interaction concepts. The ideal prototyping methodology should offer high fidelity at a relatively low cost. This thesis describes the development of interaction concepts for controlling consume
The study analyses postfeminism in an organisational context from a critical feminist perspective by exploring the contemporary perceptions of gender and gender equality in a female student career network. Furthermore, the study aims to investigate how these perceptions are projected and how they relate to organisational values, principles and processes of the organisation. Hence, How does postfem
Sammanfattning Titel: Det ska vara ”a” att åka kollektivt - en studie av servicens betydelse för organisationer som befinner sig på en marknad utan direkta konkurrenter Vad: Kandidatuppsats (SMTX06), Campus Helsingborg, Lunds Universitet, VT-2009 Författare: Anna Bergner, Carolina von Rosen, Vanja Sredojevic Handledare: Erika Andersson Cederholm & Johan Hultman Nyckelord: Service, värdeskapand
Cancer-associated gene fusions resulting in chimeric proteins or aberrant expression of one or both partner genes are pathogenetically and clinically important in several hematologic malignancies and solid tumors. Since the advent of different types of massively parallel sequencing (MPS), the number of identified gene fusions has increased dramatically, prompting the question whether they all have
Patient choice of treatment provider was introduced within opioid substitution treatment in the southern Swedish county of Skåne in 2014. Substitution treatment has often been criticised for being strict, rule-based, and driven by an ethos of discipline. This study explores the patients’ views and experiences of patient choice, particularly as a potential means of empowerment. The study is based o
BACKGROUND: European guidelines recommend the use of a 0h/1h hs-cTn (high-sensitivity cardiac troponin) protocol in patients with acute chest pain. We aimed to determine the performance of this protocol in routine care when supplemented with patient history and ECG and a recommendation to refrain from noninvasive testing in low-risk patients.METHODS AND RESULTS: This was a pre- and postimplementat
Title: Pricing of Consultant Services within the Construction Industry – Introducing Alternative Pricing Models Authors: Emma Nilsson and Jenny Persson Tutors: Elisabeth Attebrant – Regional Director, East, Sweco Management Göran Alsén – Department of Business Administration, Lund School of Economics and Management, Lund University Bertil Nilsson – Department of Production Management, Faculty
Aim: This randomised controlled trial evaluated changes in parental self-efficacy and children's weight, after a Child-Centred Health Dialogue about preventing obesity. Methods: We randomly assigned 37 Child Health Centres in Skåne county Sweden to provide usual care or the dialogue intervention. They included centres from high and low socioeconomic areas. The outcomes were changes in parental sel
Direct cellular reprogramming has recently gained attention of cancer researchers for the possibility to convert undifferentiated cancer cells into more differentiated, postmitotic cell types. While a few studies have attempted reprogramming of glioblastoma (GBM) cells toward a neuronal fate, this approach has not yet been used to induce differentiation into other lineages and in vivo data on redu
This detailed volume presents a diverse set of methodological approaches designed to improve our understanding of bacterial infections from a wide range of bacterial species. Beginning with biofilms and subcellular compartments, the book explores transcriptional analysis, methods for studying plasmid dynamics, and tools for phylogenetic analysis of bacterial genomes, as well as bacterial effector
Background: Previous population-based studies investigating the relationship between physical activity and the gut microbiota have relied on self-reported activity, prone to reporting bias. Here, we investigated the associations of accelerometer-based sedentary (SED), moderate-intensity (MPA), and vigorous-intensity (VPA) physical activity with the gut microbiota using cross-sectional data from th
Objectives Better understanding of societal factors associated with COVID-19 vaccination can have important implications for public health policy to increase uptake.Methods This study investigated sociodemographic determinants of COVID-19 vaccine uptake with ≥2 doses vs 0 doses, and ≥3 doses vs 2 doses, among adults (≥18 years) in a general population from Sweden followed from 27 December 2020 (n=
The growing popularity of nature-based tourism means that the tourism industry is increasingly utilizing wilderness areas to provide visitor experiences. However, tourism activities negatively impact wilderness quality. Tourism service providers play an important role in shaping these impacts. Therefore, this study investigates their preferences regarding wilderness use and development. It focuses
