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Background: Globalization is a phenomenon which has been around since the mid- 19th century, influencing companies to either expand existing markets or entering new markets, to seek new profits. For companies with a global supply chain, the total supply chain cost is a vital factor. It is of high importance to reduce the costs in the supply chain, as lower costs will increase the profit. The case
This paper aims to examine the arguments proposed by the Obama administration regarding a U.S. military intervention in Syria due to the use of chemical weapons by the Syrian regime in 2013. During his presidency, Obama stated that the He draws a ‘red line’ at the use of chemical weapons against civilians, but the threat proved to be empty a year later when thousands of people were killed in a che
BACKGROUND AND OBJECTIVE: Nonmetastatic (M0) clear cell renal cell carcinoma (ccRCC) recurs in ∼20% of patients within 5 yr after surgery. With no biomarkers available, recurrence detection relies on radiological imaging. Urine glycosaminoglycan profiles (GAGomes) were previously associated with M0 ccRCC recurrence. We conducted an observational prospective multicentre diagnostic test cohort study
Introduction: Population-based registers provide an important source of real-world data. The growing number of large cohort studies using data from cancer registers makes validation of such registers important. The Swedish Quality Register of Gynecologic Cancer (SQRGC) is a nationwide population-based register containing data on patient and tumor characteristics, treatment, and follow-up. To ensur
Introduction: Acute lower limb ischemia (ALI) is a life and limb threatening event often affecting patients with type 2 diabetes mellitus (T2DM). Little is known about how T2DM affects the risk of adverse events in patients revascularized for ALI. This study aimed to investigate if there were differences in major outcomes between ALI patients with and without T2DM. Methods: Between 2010 and 2014,
A combination of searches for singly and doubly charged Higgs bosons, H± and H±±, produced via vector-boson fusion is performed using 140 fb−1 of proton–proton collisions at a centre-of-mass energy of 13 TeV, collected with the ATLAS detector during Run 2 of the Large Hadron Collider. Searches targeting decays to massive vector bosons in leptonic final states (electrons or muons) are considered. N
Background: Many traumatic brain injury (TBI) treatment protocols, including the Lund concept, advocate the highest point of the subarachnoid space (typically the vertex) as the zero-reference point for intracranial pressure (ICP) and the level of the right atrium as the zero-reference point for mean arterial blood pressure (MAP). In 2017, at the Department of Neurosurgery in Lund, Sweden, the zer
Background: Amyotrophic lateral sclerosis (ALS) is invariably fatal but there are large variations in the rate of progression. The lack of predictability can make it difficult to plan clinical interventions. This includes the requirement for gastrostomy where early or late placement can adversely impact quality of life and survival. Methods: We designed a model to predict the timing of gastrostomy
Background: Retention of study participants in observational studies is essential to maintaining the representativeness of the population, minimizing selection bias, and assuring sufficient statistical power. The aim of this report is to describe the structures and strategies used to retain participants in The Environmental Determinants of Diabetes in the Young (TEDDY) Study, an observational stud
OBJECTIVES: To reach agreement among experts on visual assessments of postural orientation errors (POEs) during the single-leg squat (SLS), and to use expert agreement assessments as ground truth for machine learning (ML) models to evaluate their ability to classify POEs.DESIGN: Methodological study with mixed-methods design.METHODS: POEs of the lower extremity and trunk were assessed from videos
Objective: To highlight experiences from a personal data incident, which occurred during recruitment for a project focused on how housing choices and relocation are related to active and healthy ageing. Results: Based on established collaboration, the researchers and representatives of housing companies planned for recruitment. Invitations to participate was distributed to persons registered with
Bioelectronics holds great potential as therapeutics, but introducing conductive structures within the body poses great challenges. While implanted rigid and substrate-bound electrodes often result in inflammation and scarring in vivo, they outperform the in situ-formed, more biocompatible electrodes by providing superior control over electrode geometry. For example, one of the most researched met
Background: Compared to negative experiences and ill health, little attention has been paidto positive experiences connected to being transgender and gender diverse (TGD).Aim: The aim of the current study was to explore TGD people’s positive experiences in depth.Methods: In total, 33 TGD people were interviewed. Transcripts were analyzed using reflexivethematic analysis.Results: Results show that
Background. Primary glomerular disease (PGD) is a major cause of end-stage kidney disease (ESKD) leading to kidney replacement therapy (KRT). We aimed to describe incidence (trends) in individuals starting KRT for ESKD due to PGD and to examine their survival and causes of death. Methods. We used data from the European Renal Association (ERA) Registry on 69 854 patients who started KRT for ESKD du
Background: Digital work can be cognitively challenging especially for people with cognitive difficulties. New occupational therapy interventions are needed to empower these persons to self-manage challenges in digital work and everyday life. To address this need, the internet-based intervention 'Strategies for Empowering Activities in Everyday Life' (SEE 2.0) was tested.Aim: To explore and descri
Human biomonitoring (HBM) frameworks assess human exposure to hazardous chemicals. In this review, we discuss and summarize sample preparation procedures and analytical methodology for six groups of chemicals of emerging concern (CECs), namely diisocyanates, benzotriazoles, benzothiazoles, 4-methylbenzylidene camphor, isothiazolinones, fragrances, and non-phthalate plasticizers, which are increasi
AIMS: Lumbar disc prolapse is a frequent indication for surgery. The few available long-term follow-up studies focus mainly on repeated surgery for recurrent disease. The aim of this study was to analyze all reasons for additional surgery for patients operated on for a primary lumbar disc prolapse. METHODS: We retrieved data from the Swedish spine register about 3,291 patients who underwent primar
