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Add-on pramipexole for anhedonic depression : study protocol for a randomised controlled trial and open-label follow-up in Lund, Sweden

INTRODUCTION: Many depressed patients do not achieve remission with available treatments. Anhedonia is a common residual symptom associated with treatment resistance as well as low function and quality of life. There are currently no specific and effective treatments for anhedonia. Some trials have shown that dopamine agonist pramipexole is efficacious for treating depression, but more data is nee

The transition from children to young people living with home mechanical ventilation

Purpose: This study aimed to examine how young people living with Home Mechanical Ventilation experience the transition from childhood to young adulthood in relation to everyday life, perceived health and transition into adult professional healthcare. Methods: Nine young adults (three females and six males aged 18–31) were interviewed, and data was primary analysed using phenomenological hermeneut

Predicting adverse cardiac events at the emergency department : A deep learning approach

The emergency department is a stressful environment, in which physicians are required to make fast and accurate diagnostic assessments amidst an ever increasing flood of clinical information, including a growing body of medical knowledge. Meanwhile, the digitization of medical health records in combination with recent breakthroughs in Artificial Intelligence is ushering in a new era of precision m

A biophotonic platform for quantitative analysis in the spatial, spectral, polarimetric, and goniometric domains

Advanced instrumentation and versatile setups are needed for understanding light interaction with biological targets. Such instruments include (1) microscopes and 3D scanners for detailed spatial analysis, (2) spectral instruments for deducing molecular composition, (3) polarimeters for assessing structural properties, and (4) goniometers probing the scattering phase function of, e.g., tissue slab

Single-cell transcriptional and functional analysis of dopaminergic neurons in organoid-like cultures derived from human fetal midbrain

Significant efforts are ongoing to develop refined differentiation protocols to generate midbrain dopamine (DA) neurons from pluripotent stem cells (PSCs) for application in disease modeling, diagnostics, drug screening, and cell-based therapies for Parkinson's Disease (PD). An increased understanding of the timing and molecular mechanisms promoting the generation of distinct subtypes of human mid

Kommunal tillsyn enligt lagen om skydd mot olyckor - förslag till strukturerat arbetssätt

The new Civil Protection Act takes a more holistic view at accident prevention and protection than previous fire and safety regulations. The level of detailed regulation has decreased and national performance objectives have been formulated instead. The main purpose of this report is to present proposals for how municipalities, systematically and effectively, can plan and conduct inspection activi

Phase-matched extreme-ultraviolet frequency-comb generation

Extreme ultraviolet (XUV) laser radiation is commonly produced via high-harmonic generation (HHG) in gases. The lasers that drive this process typically operate at low pulse repetition rates (<100 kHz). Under these operating conditions, the plasma generated by each laser pulse clears the generation volume before the next pulse arrives. Therefore, each laser pulse interacts with fresh plasma-free g

Children's Experiences of Communication in Everyday Life Following Posterior Fossa Tumour Surgery—A Sense of Belonging While Navigating Reality

Background: Posterior fossa tumours (PFT) are the most common childhood brain tumours, and children treated for these tumours are at increased risk of persistent speech, language and/or communication difficulties. Such difficulties have often been described in association with the postoperative complication cerebellar mutism syndrome (CMS), but can also occur in children without a period of mutism

Big Science, Big Data, Big Innovation? : ERIC Policies on IP, Data and Technology Transfer

Science originates knowledge and downstream innovation. “Big” science is likely to, along the line, give rise to “big” innovation. Large research infrastructures are characterized by containing a large number of partners involved in complex networks of internal and external collaborations. This chapter explores how large research infrastructures (broadly defined) manage internally and externally t

AtlFast3: The Next Generation of Fast Simulation in ATLAS

The ATLAS experiment at the Large Hadron Collider has a broad physics programme ranging from precision measurements to direct searches for new particles and new interactions, requiring ever larger and ever more accurate datasets of simulated Monte Carlo events. Detector simulation with Geant4 is accurate but requires significant CPU resources. Over the past decade, ATLAS has developed and utilized

Protocol summary and statistical analysis plan for the Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest (TAME) trial

Background: Targeted therapeutic mild hypercapnia may attenuate brain injury in comatose adults resuscitated from out-of-hospital cardiac arrest. Objective: To describe the study protocol and statistical analysis plan for the Targeted Therapeutic Mild Hypercapnia after Resuscitated Cardiac Arrest (TAME) trial. Design, setting, participants and interventions: TAME is a phase 3, multicentre, paralle

Multiple Representation for Geospatial Linked Data

Current techniques for visualising geospatial Linked Data are limited in terms of multiple representation, which has been studied for decades by cartographers and considered as a prerequisite for deriving appropriate geovisualisation applications. In order to alleviate this issue, this paper presents a work in progress, in which the multiple representation geospatial data are released as Linked Da

Efficacy and safety of varenicline and bupropion, in combination and alone, for alcohol use disorder : a randomized, double-blind, placebo-controlled multicentre trial

Background: Alcohol use disorder (AUD) is associated with an enormous burden of disease and cost to society. The dopamine deficiency hypothesis posits that negative reinforcement generated by a low brain dopamine state drives ethanol intake. Here, we evaluated the efficacy and safety of combined administration of two dopamine-enhancing drugs, varenicline (a partial nicotinic acetylcholine receptor

Cancer rehabilitation in clinical practice : a qualitative study exploring contact nurses’ views on prerequisites

Background: Individualized cancer rehabilitation should be an integral part of cancer care. Contact nurses play a key role in identifying patient needs and coordinating evidence-based interventions to support rehabilitation. However, cancer rehabilitation remains marginal in current practice, as contact nurses face challenges due to the lack of systematic processes for assessment, intervention, an

Förhoppningen är vassare problemlösning inom VA-branschen

Förhoppningen är vassare problemlösning inom VA-branschen Hoppa till huvudinnehåll Vi använder cookies och andra spårningsteknologier för att förbättra användarupplevelsen på vår webbplats, för att visa dig personligt innehåll och riktade annonser och för att analysera vår webbplatstrafik. Läs mer om cookies. Absolut nödvändiga cookies Dessa cookies är nödvändiga för att webbplatsen ska fungera oc

https://www.lth.se/article/foerhoppningen-aer-vassare-problemloesning-inom-va-branschen/ - 2026-04-20

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LTH-nytt Innovationer till nytta för klimatet Vätgasens återkomst Tala om hållbara livsmiljöer Avkall på avfall LTH | LUNDS TEKNISKA HÖGSKOLA | MAGASIN | NR 2 2019 Klimathopp – finns det? I detta nummer TILL NYTTA FÖR | KLIMATET ................................................ 4 Fossilfrihet – hur når vi dit? .................................................. 7 Med IPCC-uppdrag – Lars J Nilsson ..

https://www.lth.se/fileadmin/lth/omlth/kommunikation/lthnytt/LTH-nytt_2_2019_uppslag.pdf - 2026-05-09

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Master’s Dissertation Structural Mechanics Report TV SM -5233 BJÖ RN PED ERSEN C O N C EPTU A L D Y N A M IC A N A LY SIS O F A V EH IC LE B O D Y BJÖRN PEDERSEN CONCEPTUAL DYNAMIC ANALYSIS OF A VEHICLE BODY 5233HO.indd 15233HO.indd 1 2018-10-19 15:37:512018-10-19 15:37:51 DEPARTMENT OF CONSTRUCTION SCIENCES DIVISION OF STRUCTURAL MECHANICS ISRN LUTVDG/TVSM--18/5233--SE (1-103) | ISSN 0281-6679 MA

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5233.pdf - 2026-05-09

Stora investeringar krävs i städernas elnät för att klara extremväder

Stora investeringar krävs i städernas elnät för att klara extremväder Hoppa till huvudinnehåll Vi använder cookies och andra spårningsteknologier för att förbättra användarupplevelsen på vår webbplats, för att visa dig personligt innehåll och riktade annonser och för att analysera vår webbplatstrafik. Läs mer om cookies. Absolut nödvändiga cookies Dessa cookies är nödvändiga för att webbplatsen sk

https://www.lth.se/article/stora-investeringar-kraevs-i-staedernas-elnaet-foer-att-klara-extremvaeder/ - 2026-05-09