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Introduction. Manual delineation of the left ventricle is clinical standard for quantification of cardiovascular magnetic resonance images despite being time consuming and observer dependent. Previous automatic methods generally do not account for one major contributor to stroke volume, the long-axis motion. Therefore, the aim of this study was to develop and validate an automatic algorithm for ti
A series of Na0.67Ni0.33Mn0.67-xSnxO2 (x = 0, 0.01, 0.03, 0.05) materials with mixed P2/P3 phases are synthesized with a conventional solid-state reaction method and investigated as cathode materials for sodium ion batteries. The effects of Sn substitution on the structure and electrochemical performance of the Na0.67Ni0.33Mn0.67O2 are systematically investigated. The substituted samples show smal
Nocturia, the urge to wake from sleep to void, is targeted sub-optimally by existing drugs that modulate circadian dysregulation of urine production in kidney without alleviating detrusor overactivity, a key aspect in the multifactorial etiology of nocturia. This study reports age-related upregulation of arginine vasopressin (AVP) synthesis in mouse urinary bladder to counter the concurrent declin
Popular Abstract in Swedish Det är sedan länge känt att för samma bildkvalitet kan patientstråldosen variera kraftigt mellan två olika sjukhus för en och samma röntgenundersökning. Det finns ett stort utrymme för sänkning av patientstråldosen utan att undersökningens kvalitet påverkas. Vid optimering inom röntgendiagnostik balanseras patientstråldos mot bildkvalitet. Optimeringen kräver att man haOptimisation in diagnostic radiology requires accurate methods for determination of patient absorbed dose and clinical image quality. Simple methods for evaluation of clinical image quality are at present scarce and this project aims at developing such methods. Two methods are used and further developed; fulfilment of image criteria (IC) and visual grading analysis (VGA). Clinical image quality de
For the development of single–ion irradiation system for living cells at the Lund Ion Beam Analysis facility (LIBAF) newly developed pre-cell (PC) detectors have been investigated. Central to the thesis is the fabrication and initial characterization of more than 100 ultra-thin silicon detectors having different thicknesses down to 5 μm with active areas ranging from 0.71 to 0.172 mm2, to be used
This book chapter discusses and evaluates four different efforts to extend human life: Normalize ageing, Optimize ageing, Retard ageing and postpone death, and Eliminate or overcome ageing and death. I suggest that improved treatment of disease and handicap at all ages should be welcomed. As a secondary effect, this may in many cases result in an extension of individual lives. However, the direct
Purpose: The purpose of the study is to gain a deeper understanding of how MaaS business models can be designed and configured. Theoretical Perspective: The theoretical perspective is provided by a preliminary framework which consists of a synthesis between Business model theory and MaaS literature. Methodology: A qualitative single case study was employed with an abductive research approach. E
Despite its importance, rural groundwater quality in Rwanda remains insufficiently monitored. This study aimed to investigate the groundwater quality, its health implications as well as how management can be improved to reduce the health risks of rural boreholes in the Nyagatare district in Rwanda. In total 61 boreholes were visited and 48 groundwater samples were collected. Analysis was conducted
This thesis examines how outnovation is enacted within design entrepreneurship, with fashion design entrepreneurship as the empirical context. It analyses how value formed through design practice may contribute to sustainable competitive advantage. Understood as an alternative innovation logic centred on authenticity, nostalgia, simplicity, and sustainability, outnovation offers a counterpoint to
Swedish municipalities play a key role in identifying essential services and critical infrastructures at the local level. However, there seems to be a lack of systematism to the current identification process. Since the identified essential services and infrastructures are input data for further analyses, the lack of systematism has far-reaching effects. The study is intended to examine the curren
Electromagnetic compatibility (EMC) is a vital part of product development, and understanding the sources and causes of the emissions can facilitate tremendously in reaching compliance requirements and reduce the work needed for troubleshooting. At Axis Communications, where this thesis has taken place, the knowledge of EMC is an important part of their work and they aspire to improve further. Thi
Background: Regular, detailed reporting on population health by underlying cause of death is fundamental for public health decision making. Cause-specific estimates of mortality and the subsequent effects on life expectancy worldwide are valuable metrics to gauge progress in reducing mortality rates. These estimates are particularly important following large-scale mortality spikes, such as the COV
Background: Estimates of demographic metrics are crucial to assess levels and trends of population health outcomes. The profound impact of the COVID-19 pandemic on populations worldwide has underscored the need for timely estimates to understand this unprecedented event within the context of long-term population health trends. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2
Objective: Evaluate the impact of adrenalectomy on metabolic parameters and quality of life (QoL) in patients with mild autonomous cortisol secretion (MACS). Method: A multicenter prospective randomized clinical trial compared adrenalectomy with conservative management. Metabolic parameters and QoL were assessed at baseline and after 2 years. Results: Forty-three MACS patients with a single adrena
Objective: Ampullary neoplastic lesions can be resected by endoscopic papillectomy (EP) or transduodenal surgical ampullectomy (TSA) while pancreaticoduodenectomy is reserved for more advanced lesions. We present the largest retrospective comparative study analysing EP and TSA. Design: Of all patients in the database, lesions with prior interventions, benign histology advanced malignancy (T2 and m
Background: Inadequate health literacy increases medical costs and leads to poor health outcomes. However, there is a paucity of empirical evidence of such associations in sub-Saharan Africa. This study investigates how the household cost of malaria in children under five in Ghana varies based on different levels of health literacy. Methods: A cross-sectional survey involving 1270 caregivers of ch
Background: People with intellectual disabilities experience significant health inequities. Digital interventions for health promotion are rarely designed from their specific needs. This study aimed to uncover core qualities of digital interventions for health promotion by exploring factors influencing health behaviours amongst people with intellectual disabilities. Methods: This study was conduct
Background: Most multiple sclerosis (MS) patients succumb to a progressive phenotype. Continued lymphocyte activity in the brain, microglia-mediated injury, iron deposition, and oxidative stress are characteristics of progressive MS. Objective: As minocycline and hydroxychloroquine have been shown to inhibit microglia, we evaluated their effects on other outcomes relevant for progression. Methods:
