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BACKGROUND: Liver resection is a possibly curative treatment for colorectal cancer (CRC) liver metastases. Preoperative chemotherapy may make initially irresectable tumors resectable. The aim of this study was to compare perioperative course and short-term mortality after liver resection for CRC metastases between patients who were and were not treated with preoperative chemotherapy. METHODS: Pati
Aims: This study summarises the health-related quality of life (HRQOL) scores and absenteeism caused by sinus problems in patients awaiting surgery with the diagnoses recurrent acute rhinosinusitis (RARS), chronic rhinosinusitis with nasal polyps (CRS+NP) or CRS without nasal polyps (CRS-NP), in a prospective multi-centre study. Methodology: Two hundred and seven patients with RARS, CRS+NP or CRS-
Biträdande universitetslektor (tjänstledig) Kontaktinformation E-post: martina [dot] axmin [at] jur [dot] lu [dot] se Telefon: +46 46 222 11 80Organisation Juridiska institutionen Hämtställe: 56 WebbplatsMartina Axmins profil i Lunds universitets forskningsportalAndra roller Forskare Mänskliga rättigheter Forskare Norma Research Programme Profilområdesmedlem LU profilområde: Proaktivt åldrande For
https://www.jur.lu.se/martina-axmin - 2026-07-20
Older adults have multiple medical and social care needs, requiring a shift toward an integrated person-centered model of care. Our objective was to describe and summarize Swedish experiences of integrated person-centered care by reviewing studies published between 2000 and 2023, and to identify the main challenges and scientific gaps through expert discussions. Seventy-three publications were ide
IMPORTANCE: Behavior therapy is a recommended intervention for Tourette syndrome (TS) and chronic tic disorder (CTD), but availability is limited and long-term effects are uncertain.OBJECTIVE: To investigate the long-term efficacy and cost-effectiveness of therapist-supported, internet-delivered exposure and response prevention (ERP) vs psychoeducation for youths with TS or CTD.DESIGN, SETTING, AN
Alternative fuels, such as natural and bio-gas, are attractive options for reducing greenhouse gas emissions from combustion engines. However, the naturally occurring variation in gas composition poses a challenge and may significantly impact engine performance. The gas composition affects fundamental fuel properties such as flame propagation speed and heat release rate. Deviations from the gas co
Overuse of antibiotics is accelerating the antimicrobial resistance among pathogenic microbes which is a growing public health challenge at the global level. Higher resistance causes severe infections, high complications, longer stays at hospitals and even increased mortality rates. Antimicrobial resistance (AMR) has a significant impact on national economies and their health systems, as it affect
We have previously described a new series of selective and orally available galectin-1 inhibitors resulting in the thiazole-containing glycomimetic GB1490. Here, we show that the introduction of polar substituents to the thiazole ring results in galectin-1-specific compounds with low nM affinities. X-ray structural analysis of a new ligand-galectin-1 complex shows changes in the binding mode and l
Frontotemporal dementia (FTD) is the second most common cause of early-onset dementia after Alzheimer disease (AD). Efforts in the field mainly focus on familial forms of disease (fFTDs), while studies of the genetic etiology of sporadic FTD (sFTD) have been less common. In the current work, we analyzed 4,685 sFTD cases and 15,308 controls looking for common genetic determinants for sFTD. We found
Citizens have increasingly diversified their use of social media platforms, raising questions about which platforms are adopted and for what purposes. We use survey data from four countries (Canada, France, the United States, and the United Kingdom) gathered in 2019 and 2021 (n = 12,302) about Facebook, YouTube, Instagram, Twitter, Reddit, Snapchat, and WhatsApp. Political ideology predicts the ad
Both trio and population designs are popular study designs for identifying risk genetic variants in genome-wide association studies (GWASs). The trio design, as a family-based design, is robust to confounding due to population structure, whereas the population design is often more powerful due to larger sample sizes. Here, we propose KnockoffHybrid, a knockoff-based statistical method for hybrid a
Presented is the search for anomalous Higgs boson decays into two axion-like particles (ALPs) using the full Run 2 data set of 140fb-1 of proton-proton collisions at a centre-of-mass energy of 13TeV recorded by the ATLAS experiment. The ALPs are assumed to decay into two photons, providing sensitivity to recently proposed models that could explain the (g-2)μ discrepancy. This analysis covers an AL
RNA sequencing (RNAseq) methodology has experienced a burst of technological developments in the last decade, which has opened up opportunities for studying the mechanisms of adaptation to environmental factors at both the organismal and cellular level. Selecting the most suitable experimental approach for specific research questions and model systems can, however, be a challenge and researchers i
PURPOSEAdjuvant radiotherapy (RT) is used for women with early-stage invasive breast cancer treated with breast-conserving surgery. However, some women with low risk of recurrence may safely be spared RT. This study aimed to identify these women using a molecular-based approach.METHODSWe analyzed two randomized trials of women with node-negative invasive breast cancer to ± RT following breast-cons
Background: The emergence of disease-modifying Alzheimer’s (AD) treatments provides new hope to patients and families but concerns have been raised about the preparedness of healthcare systems to provide timely access to such treatments because of a combination of a complex diagnostic process and a large prevalent pool. Objectives: We assess the preparedness of Sweden, a high-income country known
The objectives were to translate the University of Jyvaskyla Active Aging Scale (UJACAS) to Swedish, to establish semantic equivalence and evaluate psychometric properties for use among persons 55 years and older in Sweden. The UJACAS contains 17 items to be self-assessed regarding goals, abilities, opportunity, and activity. Psychometric properties content validity, data quality including floor a
Vaccine hesitancy is considered as one of the greatest challenges to control the ongoing coronavirus disease 2019 (COVID-19) pandemic. A related challenge is the unwillingness of the general public to pay for vaccination. The objective of this study was to determine willingness-to-pay (WTP) for COVID-19 vaccine among individuals from ten low-middle-income countries (LMICs) in Asia, Africa, and Sou
This issue of Leadership marks our first full year as Co-Editors-in-Chief. As we highlighted in our introductory editorial (Edwards and Schedlitzki, 2023) we see our role as striving to develop the community of the journal in its endeavour to be a key, critical and contemporary voice for leadership studies. To continue this journey, and to help contributors frame and develop their work for submiss
Hydrogen stands out as a compelling alternative to fossil fuels for combustion engines. Predictive combustion models are instrumental in developing hydrogen-fuelled engines. A fundamental metric of these models is the laminar burning velocity (LBV), which can be precisely determined through laminar flame propagation simulations. In this context, the selection of an appropriate combustion mechanism
